Atomically flat single-crystalline gold nanostructures for plasmonic nanocircuitry.

abstract：:The Non-Proliferation Treaty and other non-proliferation agreements are in place worldwide to ensure that nuclear material and facilities are used only for peaceful purposes. Antineutrino detectors, sensitive to reactor power and fuel changes, can complement the tools already at the disposal of international agencies ...

journal_title：Nature communications

authors： Stewart C,Abou-Jaoude A,Erickson A

更新日期：2019-08-06 00:00:00

abstract：:Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20-30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global expression following induction of each TF. The MTB DNA-binding network consists of ~16,000 binding events from 154...

journal_title：Nature communications

authors： Minch KJ,Rustad TR,Peterson EJ,Winkler J,Reiss DJ,Ma S,Hickey M,Brabant W,Morrison B,Turkarslan S,Mawhinney C,Galagan JE,Price ND,Baliga NS,Sherman DR

更新日期：2015-01-12 00:00:00

abstract：:Grain rotation is a well-known phenomenon during high (homologous) temperature deformation and recrystallization of polycrystalline materials. In recent years, grain rotation has also been proposed as a plasticity mechanism at low temperatures (for example, room temperature for metals), especially for nanocrystalline ...

journal_title：Nature communications

authors： Wang L,Teng J,Liu P,Hirata A,Ma E,Zhang Z,Chen M,Han X

更新日期：2014-07-17 00:00:00

abstract：:Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer cell lines. ADAR1-de...

journal_title：Nature communications

authors： Gannon HS,Zou T,Kiessling MK,Gao GF,Cai D,Choi PS,Ivan AP,Buchumenski I,Berger AC,Goldstein JT,Cherniack AD,Vazquez F,Tsherniak A,Levanon EY,Hahn WC,Meyerson M

更新日期：2018-12-21 00:00:00

abstract：:Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing ne...

journal_title：Nature communications

authors： Dhandapani R,Arokiaraj CM,Taberner FJ,Pacifico P,Raja S,Nocchi L,Portulano C,Franciosa F,Maffei M,Hussain AF,de Castro Reis F,Reymond L,Perlas E,Garcovich S,Barth S,Johnsson K,Lechner SG,Heppenstall PA

更新日期：2018-04-24 00:00:00

abstract：:To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...

journal_title：Nature communications

authors： Espah Borujeni A,Zhang J,Doosthosseini H,Nielsen AAK,Voigt CA

更新日期：2020-10-05 00:00:00

abstract：:The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member. By performing a mouse-human cross...

journal_title：Nature communications

authors： Napoli M,Li X,Ackerman HD,Deshpande AA,Barannikov I,Pisegna MA,Bedrosian I,Mitsch J,Quinlan P,Thompson A,Rajapakshe K,Coarfa C,Gunaratne PH,Marchion DC,Magliocco AM,Tsai KY,Flores ER

更新日期：2020-10-14 00:00:00

abstract：:Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. The low level FROUNT expression in patients with cancer correlates with better clinical outcomes. Frount-defici...

journal_title：Nature communications

authors： Terashima Y,Toda E,Itakura M,Otsuji M,Yoshinaga S,Okumura K,Shand FHW,Komohara Y,Takeda M,Kokubo K,Chen MC,Yokoi S,Rokutan H,Kofuku Y,Ohnishi K,Ohira M,Iizasa T,Nakano H,Okabe T,Kojima H,Shimizu A,Kanegasaki S,

更新日期：2020-01-30 00:00:00

abstract：:Tumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the abilit...

journal_title：Nature communications

authors： Peng XL,Moffitt RA,Torphy RJ,Volmar KE,Yeh JJ

更新日期：2019-10-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： International Multiple Sclerosis Genetics Consortium.

更新日期：2019-07-01 00:00:00

abstract：:The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...

journal_title：Nature communications

authors： Aberg J

更新日期：2013-01-01 00:00:00

abstract：:Histone acetylation is known to affect the speed of seed germination, but the molecular regulatory basis of this remains ambiguous. Here we report that loss of function of two histone deacetylase-binding factors, SWI-INDEPENDENT3 (SIN3)-LIKE1 (SNL1) and SNL2, results in accelerated radicle protrusion and growth during...

journal_title：Nature communications

authors： Wang Z,Chen F,Li X,Cao H,Ding M,Zhang C,Zuo J,Xu C,Xu J,Deng X,Xiang Y,Soppe WJ,Liu Y

更新日期：2016-11-11 00:00:00

abstract：:Stacking faults are known as defective structures in crystalline materials that typically lower the structural quality of the material. Here, we show that a particular type of defect, that is, stacking fault tetrahedra (SFTs), exhibits pronounced quantized electronic behaviour, revealing a potential synthetic route to...

journal_title：Nature communications

authors： Schouteden K,Amin-Ahmadi B,Li Z,Muzychenko D,Schryvers D,Van Haesendonck C

更新日期：2016-12-23 00:00:00

abstract：:SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet fully clear. Here,...

journal_title：Nature communications

authors： Han C,Gu Y,Shan H,Mi W,Sun J,Shi M,Zhang X,Lu X,Han F,Gong Q,Yu W

更新日期：2017-11-14 00:00:00

abstract：:Van der Waals materials and their heterostructures offer a versatile platform for studying a variety of quantum transport phenomena due to their unique crystalline properties and the exceptional ability in tuning their electronic spectrum. However, most experiments are limited to devices that have lateral dimensions o...

journal_title：Nature communications

authors： Kumaravadivel P,Greenaway MT,Perello D,Berdyugin A,Birkbeck J,Wengraf J,Liu S,Edgar JH,Geim AK,Eaves L,Krishna Kumar R

更新日期：2019-07-26 00:00:00

abstract：:Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...

journal_title：Nature communications

authors： Zhu J,Zhang S,Zhang K,Wang X,Mays JW,Wooley KL,Pochan DJ

更新日期：2013-01-01 00:00:00

abstract：:The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, an...

journal_title：Nature communications

authors： Möller IR,Slivacka M,Nielsen AK,Rasmussen SGF,Gether U,Loland CJ,Rand KD

更新日期：2019-04-11 00:00:00

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:Organolead halide perovskites have attracted substantial attention because of their excellent physical properties, which enable them to serve as the active material in emerging hybrid solid-state solar cells. Here we investigate the phototransistors based on hybrid perovskite films and provide direct evidence for thei...

journal_title：Nature communications

authors： Li F,Ma C,Wang H,Hu W,Yu W,Sheikh AD,Wu T

更新日期：2015-09-08 00:00:00

abstract：:In most applications of nanoporous materials the pore structure is as important as the chemical composition as a determinant of performance. For example, one can alter performance in applications like carbon capture or methane storage by orders of magnitude by only modifying the pore structure. For these applications ...

journal_title：Nature communications

authors： Lee Y,Barthel SD,Dłotko P,Moosavi SM,Hess K,Smit B

更新日期：2017-05-23 00:00:00

abstract：:Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...

journal_title：Nature communications

authors： Mammoto A,Mammoto T,Kanapathipillai M,Wing Yung C,Jiang E,Jiang A,Lofgren K,Gee EP,Ingber DE

更新日期：2013-01-01 00:00:00

abstract：:Graphene nanoribbons (GNRs)-narrow stripes of graphene-have emerged as promising building blocks for nanoelectronic devices. Recent advances in bottom-up synthesis have allowed production of atomically well-defined armchair GNRs with different widths and doping. While all experimentally studied GNRs have exhibited wid...

journal_title：Nature communications

authors： Kimouche A,Ervasti MM,Drost R,Halonen S,Harju A,Joensuu PM,Sainio J,Liljeroth P

更新日期：2015-12-14 00:00:00

abstract：:During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1-α2 loop. A monoclonal antibody (clone 7D10) binds close to α1 in non-act...

journal_title：Nature communications

authors： Iyer S,Anwari K,Alsop AE,Yuen WS,Huang DC,Carroll J,Smith NA,Smith BJ,Dewson G,Kluck RM

更新日期：2016-05-24 00:00:00

abstract：:In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunne...

journal_title：Nature communications

authors： Ma C,Xiao Z,Zhang H,Liang L,Huang J,Lu W,Sumpter BG,Hong K,Bernholc J,Li AP

更新日期：2017-03-13 00:00:00

abstract：:Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. CCN1 ops...

journal_title：Nature communications

authors： Jun JI,Lau LF

更新日期：2020-03-06 00:00:00

abstract：:Temperature measurement is critical for many technological applications and scientific experiments, and different types of thermometers have been developed to detect temperature at macroscopic length scales. However, quantitative measurement of the temperature of nanostructures remains a challenge. Here, we show a new...

journal_title：Nature communications

authors： Guo H,Khan MI,Cheng C,Fan W,Dames C,Wu J,Minor AM

更新日期：2014-10-13 00:00:00

abstract：:Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal stru...

journal_title：Nature communications

authors： Yamagata A,Miyazaki Y,Yokoi N,Shigematsu H,Sato Y,Goto-Ito S,Maeda A,Goto T,Sanbo M,Hirabayashi M,Shirouzu M,Fukata Y,Fukata M,Fukai S

更新日期：2018-04-18 00:00:00

abstract：:The high photon flux and femtosecond pulse duration of hard X-ray free-electron lasers have spurred a large variety of novel and fascinating experiments in physical, chemical and biological sciences. Many of these experiments depend fundamentally on a clean, well-defined wavefront. Here we explore the wavefront proper...

journal_title：Nature communications

authors： Rutishauser S,Samoylova L,Krzywinski J,Bunk O,Grünert J,Sinn H,Cammarata M,Fritz DM,David C

更新日期：2012-07-10 00:00:00

abstract：:The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...

journal_title：Nature communications

authors： Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

更新日期：2014-07-28 00:00:00

abstract：:Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25-3,500). We estab...

journal_title：Nature communications

authors： Das P,Malho JM,Rahimi K,Schacher FH,Wang B,Demco DE,Walther A

更新日期：2015-01-20 00:00:00