Abstract:
:The damming of rivers represents one of the most far-reaching human modifications of the flows of water and associated matter from land to sea. Dam reservoirs are hotspots of sediment accumulation, primary productivity (P) and carbon mineralization (R) along the river continuum. Here we show that for the period 1970-2030, global carbon mineralization in reservoirs exceeds carbon fixation (P journal_name journal_title authors doi subject pub_date pages issn pii journal_volume pub_type
abstract::We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scannin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04576-z
更新日期:2018-06-15 00:00:00
abstract::Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1070
更新日期:2010-09-21 00:00:00
abstract::Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2741
更新日期:2013-01-01 00:00:00
abstract::Cell-to-cell variability plays a critical role in cellular responses and decision-making in a population, and transcriptional bursting has been broadly studied by experimental and theoretical approaches as the potential source of cell-to-cell variability. Although molecular mechanisms of transcriptional bursting have ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13788
更新日期:2016-12-07 00:00:00
abstract::Melting of the Greenland Ice Sheet is a leading cause of land-ice mass loss and cryosphere-attributed sea level rise. Blooms of pigmented glacier ice algae lower ice albedo and accelerate surface melting in the ice sheet's southwest sector. Although glacier ice algae cause up to 13% of the surface melting in this regi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20627-w
更新日期:2021-01-25 00:00:00
abstract::How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00735-w
更新日期:2017-09-25 00:00:00
abstract::Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show that the tumour sup...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12037
更新日期:2016-06-29 00:00:00
abstract::The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1-Mad2 is crucial for SAC activation. However, the mechanism by which Mad1-Mad2 accumulation at kinetochores...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10151
更新日期:2016-01-08 00:00:00
abstract::Anthropogenic mercury (Hg(0)) emissions oxidize to gaseous Hg(II) compounds, before deposition to Earth surface ecosystems. Atmospheric reduction of Hg(II) competes with deposition, thereby modifying the magnitude and pattern of Hg deposition. Global Hg models have postulated that Hg(II) reduction in the atmosphere oc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07075-3
更新日期:2018-11-15 00:00:00
abstract::1T-MoS2 and single-atom modified analogues represent a highly promising class of low-cost catalysts for hydrogen evolution reaction (HER). However, the role of single atoms, either as active species or promoters, remains vague despite its essentiality toward more efficient HER. In this work, we report the unambiguous ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17904-z
更新日期:2020-08-17 00:00:00
abstract::Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02677-9
更新日期:2018-01-18 00:00:00
abstract::A number of modes of oscillations of particles and fields can exist in space plasmas. Since the early 1970s, space missions have observed noise-like plasma waves near the geomagnetic equator known as 'equatorial noise'. Several theories were suggested, but clear observational evidence supported by realistic modelling ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8703
更新日期:2015-07-14 00:00:00
abstract::Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02386-3
更新日期:2017-12-21 00:00:00
abstract::Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13374
更新日期:2016-11-21 00:00:00
abstract::The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18634-y
更新日期:2020-09-25 00:00:00
abstract::Generous behaviour is known to increase happiness, which could thereby motivate generosity. In this study, we use functional magnetic resonance imaging and a public pledge for future generosity to investigate the brain mechanisms that link generous behaviour with increases in happiness. Participants promised to spend ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15964
更新日期:2017-07-11 00:00:00
abstract::The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca2+ dissipates the H+ gradient generated by ATP hydrolysis. Afte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12331-1
更新日期:2019-09-25 00:00:00
abstract::Large-scale climate patterns control variability in the global carbon sink. In Europe, the North-Atlantic Oscillation (NAO) influences vegetation activity, however the East-Atlantic (EA) pattern is known to modulate NAO strength and location. Using observation-driven and modelled data sets, we show that multi-annual v...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10315
更新日期:2016-01-18 00:00:00
abstract::Recent studies suggest that attention samples space rhythmically through oscillatory interactions in the frontoparietal network. How these attentional fluctuations coincide with spatial exploration/displacement and exploitation/selection by a dynamic attentional spotlight under top-down control is unclear. Here, we sh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14649-7
更新日期:2020-02-17 00:00:00
abstract::Marine particles transport organic matter through the water column to the sediment where the organic matter can be buried. This pathway is one of the few natural removal mechanisms of CO2 from the atmosphere over geological time. Picophytoplankton, major primary producers in the ocean, have until recently been thought...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5143
更新日期:2014-06-12 00:00:00
abstract::Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6969
更新日期:2015-01-19 00:00:00
abstract::Stable benzotriazinyl radicals (Blatter's radicals) recently attracted considerable interest as building blocks for functional materials. The existing strategies to derivatize Blatter's radicals are limited, however, and synthetic routes are complex. Here, we report that an inexpensive, commercially available, analyti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15088
更新日期:2017-05-15 00:00:00
abstract::Phase-coherent transfer of optical frequencies over a long distance is required for diverse photonic applications, including optical clock dissemination and physical constants measurement. Several demonstrations were made successfully over fiber networks, but not much work has been done yet through the open air where ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12443-8
更新日期:2019-09-30 00:00:00
abstract::Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without decreasing pathogen load. Here, we demonstrate that in four different mouse models of malaria, adrenal hormones confer disease tolerance and protect against early ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06986-5
更新日期:2018-10-30 00:00:00
abstract::Two-dimensional layered transition-metal dichalcogenides have attracted considerable interest for their unique layer-number-dependent properties. In particular, vertical integration of these two-dimensional crystals to form van der Waals heterostructures can open up a new dimension for the design of functional electro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13278
更新日期:2016-11-09 00:00:00
abstract::Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06939-y
更新日期:2018-10-26 00:00:00
abstract::Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20822-9
更新日期:2021-01-28 00:00:00
abstract::We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine CD8+ T-cell and lymphocytic leukemia cell line lineages. Here we repor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10220
更新日期:2016-01-06 00:00:00
abstract::Synapse formation is triggered through trans-synaptic interaction between pairs of pre- and postsynaptic adhesion molecules, the specificity of which depends on splice inserts known as 'splice-insert signaling codes'. Receptor protein tyrosine phosphatase δ (PTPδ) can bidirectionally induce pre- and postsynaptic diffe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7926
更新日期:2015-04-24 00:00:00
abstract::Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8758
更新日期:2015-07-14 00:00:00