Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.

abstract：:Graphene nanoribbons (GNRs)-narrow stripes of graphene-have emerged as promising building blocks for nanoelectronic devices. Recent advances in bottom-up synthesis have allowed production of atomically well-defined armchair GNRs with different widths and doping. While all experimentally studied GNRs have exhibited wid...

journal_title：Nature communications

authors： Kimouche A,Ervasti MM,Drost R,Halonen S,Harju A,Joensuu PM,Sainio J,Liljeroth P

更新日期：2015-12-14 00:00:00

abstract：:Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibo...

journal_title：Nature communications

authors： Ku Z,Xie X,Davidson E,Ye X,Su H,Menachery VD,Li Y,Yuan Z,Zhang X,Muruato AE,I Escuer AG,Tyrell B,Doolan K,Doranz BJ,Wrapp D,Bates PF,McLellan JS,Weiss SR,Zhang N,Shi PY,An Z

更新日期：2021-01-20 00:00:00

abstract：:MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 i...

journal_title：Nature communications

authors： Liu C,Liu R,Zhang D,Deng Q,Liu B,Chao HP,Rycaj K,Takata Y,Lin K,Lu Y,Zhong Y,Krolewski J,Shen J,Tang DG

更新日期：2017-01-23 00:00:00

abstract：:Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8(+) T cells requires cortical thymic epithelial cells that express β5t-cont...

journal_title：Nature communications

authors： Sasaki K,Takada K,Ohte Y,Kondo H,Sorimachi H,Tanaka K,Takahama Y,Murata S

更新日期：2015-06-23 00:00:00

abstract：:Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...

journal_title：Nature communications

authors： Xu S,Wang W,Li H,Zhang J,Chen R,Wang S,Zheng C,Xing G,Song C,Huang W

更新日期：2020-09-23 00:00:00

abstract：:Leads are a key feature of the Arctic ice pack during the winter owing to their substantial contribution to the surface energy balance. According to the present understanding, enhanced heat and moisture fluxes from high lead concentrations tend to produce more boundary layer clouds. However, described here in our comp...

journal_title：Nature communications

authors： Li X,Krueger SK,Strong C,Mace GG,Benson S

更新日期：2020-01-10 00:00:00

abstract：:Ribosomes are essential intracellular machines composed of proteins and RNA molecules. The DNA sequences (rDNA) encoding ribosomal RNAs (rRNAs) are tandemly repeated and give origin to the nucleolus. Here we develop a computational method for estimating rDNA dosage (copy number) and mitochondrial DNA abundance using w...

journal_title：Nature communications

authors： Gibbons JG,Branco AT,Yu S,Lemos B

更新日期：2014-09-11 00:00:00

abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...

journal_title：Nature communications

authors： Handley C,Mathew S

更新日期：2020-02-04 00:00:00

abstract：:The intrinsic variability of switching behavior in memristors has been a major obstacle to their adoption as the next generation of universal memory. On the other hand, this natural stochasticity can be valuable for hardware security applications. Here we propose and demonstrate a novel true random number generator ut...

journal_title：Nature communications

authors： Jiang H,Belkin D,Savel'ev SE,Lin S,Wang Z,Li Y,Joshi S,Midya R,Li C,Rao M,Barnell M,Wu Q,Yang JJ,Xia Q

更新日期：2017-10-12 00:00:00

abstract：:In the original version of this Article, an additional double-headed arrow was inadvertently included within Fig. 3e. This error has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Gokhale S,Conwill A,Ranjan T,Gore J

更新日期：2019-02-12 00:00:00

abstract：:Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic ...

journal_title：Nature communications

authors： Scheler U,Brandt W,Porzel A,Rothe K,Manzano D,Božić D,Papaefthimiou D,Balcke GU,Henning A,Lohse S,Marillonnet S,Kanellis AK,Ferrer A,Tissier A

更新日期：2016-10-05 00:00:00

abstract：:In humans, males have lower recombination rates than females over the majority of the genome, but the opposite is usually true near the telomeres. These broad-scale differences have been known for decades, yet little is known about differences at the fine scale. By combining data sets, we have collected recombination ...

journal_title：Nature communications

authors： Bhérer C,Campbell CL,Auton A

更新日期：2017-04-25 00:00:00

abstract：:In addition to acting as a cellular energy source, ATP can also act as a damage-associated molecular pattern in both animals and plants. Stomata are leaf pores that control gas exchange and, therefore, impact critical functions such as photosynthesis, drought tolerance, and also are the preferred entry point for patho...

journal_title：Nature communications

authors： Chen D,Cao Y,Li H,Kim D,Ahsan N,Thelen J,Stacey G

更新日期：2017-12-22 00:00:00

abstract：:Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell-cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to in...

journal_title：Nature communications

authors： Doi M,Ishida A,Miyake A,Sato M,Komatsu R,Yamazaki F,Kimura I,Tsuchiya S,Kori H,Seo K,Yamaguchi Y,Matsuo M,Fustin JM,Tanaka R,Santo Y,Yamada H,Takahashi Y,Araki M,Nakao K,Aizawa S,Kobayashi M,Obrietan K,Tsujimo

更新日期：2011-01-01 00:00:00

abstract：:Microbial community structure can be analyzed by quantifying cell numbers or by quantifying biomass for individual populations. Methods for quantifying cell numbers are already available (e.g., fluorescence in situ hybridization, 16-S rRNA gene amplicon sequencing), yet high-throughput methods for assessing community ...

journal_title：Nature communications

authors： Kleiner M,Thorson E,Sharp CE,Dong X,Liu D,Li C,Strous M

更新日期：2017-11-16 00:00:00

abstract：:Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...

journal_title：Nature communications

authors： Banjo T,Grajcarek J,Yoshino D,Osada H,Miyasaka KY,Kida YS,Ueki Y,Nagayama K,Kawakami K,Matsumoto T,Sato M,Ogura T

更新日期：2013-01-01 00:00:00

abstract：:Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

journal_title：Nature communications

authors： Tamura T,Williams GD,Fraser AD,Ohshima KI

更新日期：2012-05-08 00:00:00

abstract：:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...

journal_title：Nature communications

authors： Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ

更新日期：2019-07-19 00:00:00

abstract：:Separation of C2H4 from C2H4/C2H2/C2H6 mixture with high working capacity is still a challenging task. Herein, we deliberately design a Th-metal-organic framework (MOF) for highly efficient separation of C2H4 from a binary C2H6/C2H4 and ternary C2H4/C2H2/C2H6 mixture. The synthesized MOF Azole-Th-1 shows a UiO-66-type...

journal_title：Nature communications

authors： Xu Z,Xiong X,Xiong J,Krishna R,Li L,Fan Y,Luo F,Chen B

更新日期：2020-06-22 00:00:00

abstract：:Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behavio...

journal_title：Nature communications

authors： Huang L,Yuan T,Tan M,Xi Y,Hu Y,Tao Q,Zhao Z,Zheng J,Han Y,Xu F,Luo M,Sollars PJ,Pu M,Pickard GE,So KF,Ren C

更新日期：2017-03-31 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:Ions are ubiquitous biological regulators playing a key role for vital processes in animals and plants. The combined detection of ion concentration and real-time monitoring of small variations with respect to the resting conditions is a multiscale functionality providing important information on health states. This mu...

journal_title：Nature communications

authors： Romele P,Gkoupidenis P,Koutsouras DA,Lieberth K,Kovács-Vajna ZM,Blom PWM,Torricelli F

更新日期：2020-07-27 00:00:00

abstract：:Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the d...

journal_title：Nature communications

authors： Dutertre S,Jin AH,Vetter I,Hamilton B,Sunagar K,Lavergne V,Dutertre V,Fry BG,Antunes A,Venter DJ,Alewood PF,Lewis RJ

更新日期：2014-03-24 00:00:00

abstract：:The Montreal Protocol has succeeded in limiting major ozone-depleting substance emissions, and consequently stratospheric ozone concentrations are expected to recover this century. However, there is a large uncertainty in the rate of regional ozone recovery in the Northern Hemisphere. Here we identify a Eurasia-North ...

journal_title：Nature communications

authors： Zhang J,Tian W,Xie F,Chipperfield MP,Feng W,Son SW,Abraham NL,Archibald AT,Bekki S,Butchart N,Deushi M,Dhomse S,Han Y,Jöckel P,Kinnison D,Kirner O,Michou M,Morgenstern O,O'Connor FM,Pitari G,Plummer DA,Revell LE

更新日期：2018-01-15 00:00:00

abstract：:Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...

journal_title：Nature communications

authors： Capozzi A,Cheng T,Boero G,Roussel C,Comment A

更新日期：2017-06-01 00:00:00

abstract：:Solar-driven photocatalysis has attracted significant attention in water splitting, CO2 reduction and organic synthesis. The syntheses of valuable azo- and azoxyaromatic dyes via selective photoreduction of nitroaromatic compounds have been realised using supported plasmonic metal nanoparticles at elevated temperature...

journal_title：Nature communications

authors： Dai Y,Li C,Shen Y,Lim T,Xu J,Li Y,Niemantsverdriet H,Besenbacher F,Lock N,Su R

更新日期：2018-01-04 00:00:00

abstract：:Selection rules are of vital importance in determining the basic optical properties of atoms, molecules and semiconductors. They provide general insights into the symmetry of the system and the nature of relevant electronic states. A two-dimensional electron gas in a magnetic field is a model system where optical tran...

journal_title：Nature communications

authors： Ju L,Wang L,Li X,Moon S,Ozerov M,Lu Z,Taniguchi T,Watanabe K,Mueller E,Zhang F,Smirnov D,Rana F,McEuen PL

更新日期：2020-06-10 00:00:00

abstract：:Efficient and reliable on-chip optical amplifiers and light sources would enable versatile integration of various active functionalities on the silicon platform. Although lasing on silicon has been demonstrated with semiconductors by using methods such as wafer bonding or molecular beam epitaxy, cost-effective mass pr...

journal_title：Nature communications

authors： Rönn J,Zhang W,Autere A,Leroux X,Pakarinen L,Alonso-Ramos C,Säynätjoki A,Lipsanen H,Vivien L,Cassan E,Sun Z

更新日期：2019-01-25 00:00:00

abstract：:In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. Each individual sensory epithelium is composed of highly heterogeneous populations of cells based on physiological and anatomical criteria. However, limited numbers of ...

journal_title：Nature communications

authors： Burns JC,Kelly MC,Hoa M,Morell RJ,Kelley MW

更新日期：2015-10-15 00:00:00

abstract：:We previously reported children homozygous for two MC3R sequence variants (C17A+G241A) have greater fat mass than controls. Here we show, using homozygous knock-in mouse models in which we replace murine Mc3r with wild-type human (MC3R(hWT/hWT)) and double-mutant (C17A+G241A) human (MC3R(hDM/hDM)) MC3R, that MC3R(hDM/...

journal_title：Nature communications

authors： Lee B,Koo J,Yun Jun J,Gavrilova O,Lee Y,Seo AY,Taylor-Douglas DC,Adler-Wailes DC,Chen F,Gardner R,Koutzoumis D,Sherafat Kazemzadeh R,Roberson RB,Yanovski JA

更新日期：2016-01-28 00:00:00