Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

Abstract:

:Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference (CPP). This stress-induced reinstatement of cocaine CPP depends on type 1 orexin receptors (OX1Rs), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA. In dopaminergic neurons of VTA slices, orexin A presynaptically inhibits GABAergic transmission. This effect is prevented by internal GDP-β-S or inhibiting OX1Rs, CB1Rs, phospholipase C or DAGL, and potentiated by inhibiting 2-AG degradation. These results suggest that restraint stress activates LH orexin neurons, releasing orexins into the VTA to activate postsynaptic OX1Rs of dopaminergic neurons and generate 2-AG through a Gq-protein-phospholipase C-DAGL cascade. 2-AG retrogradely inhibits GABA release through presynaptic CB1Rs, leading to VTA dopaminergic disinhibition and reinstatement of cocaine CPP.

journal_name

Nat Commun

journal_title

Nature communications

authors

Tung LW,Lu GL,Lee YH,Yu L,Lee HJ,Leishman E,Bradshaw H,Hwang LL,Hung MS,Mackie K,Zimmer A,Chiou LC

doi

10.1038/ncomms12199

subject

Has Abstract

pub_date

2016-07-22 00:00:00

pages

12199

issn

2041-1723

pii

ncomms12199

journal_volume

7

pub_type

杂志文章
  • No extension of quantum theory can have improved predictive power.

    abstract::According to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1416

    authors: Colbeck R,Renner R

    更新日期:2011-08-02 00:00:00

  • Enhanced Moran effect by spatial variation in environmental autocorrelation.

    abstract::Spatial correlations in environmental stochasticity can synchronize populations over wide areas, a phenomenon known as the Moran effect. The Moran effect has been confirmed in field, laboratory and theoretical investigations. Little is known, however, about the Moran effect in a common ecological case, when environmen...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6993

    authors: Massie TM,Weithoff G,Kuckländer N,Gaedke U,Blasius B

    更新日期:2015-01-09 00:00:00

  • Gaussian-preserved, non-volatile shape morphing in three-dimensional microstructures for dual-functional electronic devices.

    abstract::Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20843-4

    authors: Tian Z,Xu B,Wan G,Han X,Di Z,Chen Z,Mei Y

    更新日期:2021-01-21 00:00:00

  • Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.

    abstract::Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9362

    authors: Muhammad K,Reddy-Alla S,Driller JH,Schreiner D,Rey U,Böhme MA,Hollmann C,Ramesh N,Depner H,Lützkendorf J,Matkovic T,Götz T,Bergeron DD,Schmoranzer J,Goettfert F,Holt M,Wahl MC,Hell SW,Scheiffele P,Walter AM,Loll B

    更新日期:2015-10-16 00:00:00

  • Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis.

    abstract::Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3902

    authors: Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

    更新日期:2013-01-01 00:00:00

  • Metamaterials with index ellipsoids at arbitrary k-points.

    abstract::Propagation behaviors of electromagnetic waves are governed by the equifrequency surface of the medium. Up to now, ordinary materials, including the medium exist in nature and the man-made metamaterials, always have an equifrequency surface (ellipsoid or hyperboloid) centered at zero k-point. Here we propose a new typ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04490-4

    authors: Chen WJ,Hou B,Zhang ZQ,Pendry JB,Chan CT

    更新日期:2018-05-25 00:00:00

  • Enhanced acoustic sensing through wave compression and pressure amplification in anisotropic metamaterials.

    abstract::Acoustic sensors play an important role in many areas, such as homeland security, navigation, communication, health care and industry. However, the fundamental pressure detection limit hinders the performance of current acoustic sensing technologies. Here, through analytical, numerical and experimental studies, we sho...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6247

    authors: Chen Y,Liu H,Reilly M,Bae H,Yu M

    更新日期:2014-10-15 00:00:00

  • Product selectivity in plasmonic photocatalysis for carbon dioxide hydrogenation.

    abstract::Photocatalysis has not found widespread industrial adoption, in spite of decades of active research, because the challenges associated with catalyst illumination and turnover outweigh the touted advantages of replacing heat with light. A demonstration that light can control product selectivity in complex chemical reac...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14542

    authors: Zhang X,Li X,Zhang D,Su NQ,Yang W,Everitt HO,Liu J

    更新日期:2017-02-23 00:00:00

  • Non-linear response of summertime marine productivity to increased meltwater discharge around Greenland.

    abstract::Runoff from the Greenland Ice Sheet (GrIS) is thought to enhance marine productivity by adding bioessential iron and silicic acid to coastal waters. However, experimental data suggest nitrate is the main summertime growth-limiting resource in regions affected by meltwater around Greenland. While meltwater contains low...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05488-8

    authors: Hopwood MJ,Carroll D,Browning TJ,Meire L,Mortensen J,Krisch S,Achterberg EP

    更新日期:2018-08-14 00:00:00

  • Cryopreservation of infectious Cryptosporidium parvum oocysts.

    abstract::Cryptosporidiosis in an enteric infection caused by Cryptosporidium parasites and is a major cause of acute infant diarrhea in the developing world. A major bottleneck to research progress is the lack of methods to cryopreserve Cryptosporidium oocysts, thus requiring routine propagation in laboratory animals. Here, we...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05240-2

    authors: Jaskiewicz JJ,Sandlin RD,Swei AA,Widmer G,Toner M,Tzipori S

    更新日期:2018-07-23 00:00:00

  • Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing.

    abstract::Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization f...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07723-8

    authors: Mariani S,Robbiano V,Strambini LM,Debrassi A,Egri G,Dähne L,Barillaro G

    更新日期:2018-12-10 00:00:00

  • A moiré deflectometer for antimatter.

    abstract::The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5538

    authors: Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

    更新日期:2014-07-28 00:00:00

  • Imaging enzyme-triggered self-assembly of small molecules inside live cells.

    abstract::Self-assembly of small molecules in water to form nanofibres, besides generating sophisticated biomaterials, promises a simple system inside cells for regulating cellular processes. But lack of a convenient approach for studying the self-assembly of small molecules inside cells hinders the development of such systems....

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2040

    authors: Gao Y,Shi J,Yuan D,Xu B

    更新日期:2012-01-01 00:00:00

  • Rapid glacier retreat and downwasting throughout the European Alps in the early 21st century.

    abstract::Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16818-0

    authors: Sommer C,Malz P,Seehaus TC,Lippl S,Zemp M,Braun MH

    更新日期:2020-06-25 00:00:00

  • Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing.

    abstract::CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-17029-3

    authors: Wei T,Cheng Q,Min YL,Olson EN,Siegwart DJ

    更新日期:2020-06-26 00:00:00

  • The mutational landscape of a prion-like domain.

    abstract::Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause cellular toxicity is still not clear, even in simpler cellular systems. We reasoned that deep mutagene...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12101-z

    authors: Bolognesi B,Faure AJ,Seuma M,Schmiedel JM,Tartaglia GG,Lehner B

    更新日期:2019-09-13 00:00:00

  • The role of water in fault lubrication.

    abstract::The friction between two adjacent tectonic plates under shear loading may dictate seismic activities. To advance the understanding of mechanisms underlying fault strength, we investigate the frictional characteristics of calcite in an aqueous environment. By conducting single-asperity friction experiments using an ato...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04782-9

    authors: Diao Y,Espinosa-Marzal RM

    更新日期:2018-06-13 00:00:00

  • Mesoporous monoliths of inverse bicontinuous cubic phases of block copolymer bilayers.

    abstract::Solution self-assembly of block copolymers into inverse bicontinuous cubic mesophases is a promising new approach for creating porous polymer films and monoliths with highly organized bicontinuous mesoporous networks. Here we report the direct self-assembly of block copolymers with branched hydrophilic blocks into lar...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms7392

    authors: Park C,La Y,An TH,Jeong HY,Kang S,Joo SH,Ahn H,Shin TJ,Kim KT

    更新日期:2015-03-05 00:00:00

  • Symbiosis limits establishment of legumes outside their native range at a global scale.

    abstract::Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14790

    authors: Simonsen AK,Dinnage R,Barrett LG,Prober SM,Thrall PH

    更新日期:2017-04-07 00:00:00

  • Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.

    abstract::Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivity to antigen. Here we show that the heritable downregulation of CD8 during type 2 polarization of murine CD8(+) effector T cells in vitro and in vivo is associated with CpG methylation of several regions of the Cd8a locus. These epigenetic modi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4547

    authors: Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A

    更新日期:2014-03-28 00:00:00

  • Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.

    abstract::Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12738

    authors: Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

    更新日期:2016-09-27 00:00:00

  • Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency.

    abstract::Deregulation of mitochondrial network in terminally differentiated cells contributes to a broad spectrum of disorders. Methylmalonic acidemia (MMA) is one of the most common inherited metabolic disorders, due to deficiency of the mitochondrial methylmalonyl-coenzyme A mutase (MMUT). How MMUT deficiency triggers cell d...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14729-8

    authors: Luciani A,Schumann A,Berquez M,Chen Z,Nieri D,Failli M,Debaix H,Festa BP,Tokonami N,Raimondi A,Cremonesi A,Carrella D,Forny P,Kölker S,Diomedi Camassei F,Diaz F,Moraes CT,Di Bernardo D,Baumgartner MR,Devuyst O

    更新日期:2020-02-20 00:00:00

  • Upper- and mid-mantle interaction between the Samoan plume and the Tonga-Kermadec slabs.

    abstract::Mantle plumes are thought to play a key role in transferring heat from the core-mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and henc...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10799

    authors: Chang SJ,Ferreira AM,Faccenda M

    更新日期:2016-02-29 00:00:00

  • In situ spectroscopy-guided engineering of rhodium single-atom catalysts for CO oxidation.

    abstract::Single-atom catalysts have recently been applied in many applications such as CO oxidation. Experimental in situ investigations into this reaction, however, are limited. Hereby, we present a suite of operando/in situ spectroscopic experiments for structurally well-defined atomically dispersed Rh on phosphotungstic aci...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09188-9

    authors: Hülsey MJ,Zhang B,Ma Z,Asakura H,Do DA,Chen W,Tanaka T,Zhang P,Wu Z,Yan N

    更新日期:2019-03-22 00:00:00

  • Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling.

    abstract::Overcoming the restricted axonal regenerative ability that limits functional repair following a central nervous system injury remains a challenge. Here we report a regenerative paradigm that we call enriched conditioning, which combines environmental enrichment (EE) followed by a conditioning sciatic nerve axotomy tha...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20179-z

    authors: De Virgiliis F,Hutson TH,Palmisano I,Amachree S,Miao J,Zhou L,Todorova R,Thompson R,Danzi MC,Lemmon VP,Bixby JL,Wittig I,Shah AM,Di Giovanni S

    更新日期:2020-12-21 00:00:00

  • Water conservation benefits of urban heat mitigation.

    abstract::Many cities globally are seeking strategies to counter the consequences of both a hotter and drier climate. While urban heat mitigation strategies have been shown to have beneficial effects on health, energy consumption, and greenhouse gas emissions, their implications for water conservation have not been widely exami...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01346-1

    authors: Vahmani P,Jones AD

    更新日期:2017-10-20 00:00:00

  • Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice.

    abstract::Around 40% of preterm births are attributed to ascending intrauterine infection, and Ureaplasma parvum (UP) is commonly isolated in these cases. Here we present a mouse model of ascending UP infection that resembles human disease, using vaginal inoculation combined with mild cervical injury induced by a common spermic...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-14089-y

    authors: Pavlidis I,Spiller OB,Sammut Demarco G,MacPherson H,Howie SEM,Norman JE,Stock SJ

    更新日期:2020-01-10 00:00:00

  • Carrier multiplication detected through transient photocurrent in device-grade films of lead selenide quantum dots.

    abstract::In carrier multiplication, the absorption of a single photon results in two or more electron-hole pairs. Quantum dots are promising materials for implementing carrier multiplication principles in real-life technologies. So far, however, most of research in this area has focused on optical studies of solution samples w...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9185

    authors: Gao J,Fidler AF,Klimov VI

    更新日期:2015-09-08 00:00:00

  • Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 已发布勘误

    doi:10.1038/s41467-019-10951-1

    authors: International Multiple Sclerosis Genetics Consortium.

    更新日期:2019-07-01 00:00:00

  • Emergence of chirality and structural complexity in single crystals at the molecular and morphological levels.

    abstract::Naturally occurring single crystals having a multidomain morphology are a counterintuitive phenonomon: the macroscopic appearance is expected to follow the symmetry of the unit cell. Growing such crystals in the lab is a great challenge, especially from organic molecules. We achieve here uniform metallo-organic crysta...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13925-5

    authors: di Gregorio MC,Shimon LJW,Brumfeld V,Houben L,Lahav M,van der Boom ME

    更新日期:2020-01-20 00:00:00