Bio-inspired self-shaping ceramics.

abstract：:Zea mays is an important genetic model for elucidating transcriptional networks. Uncertainties about the complete structure of mRNA transcripts limit the progress of research in this system. Here, using single-molecule sequencing technology, we produce 111,151 transcripts from 6 tissues capturing ∼70% of the genes ann...

journal_title：Nature communications

authors： Wang B,Tseng E,Regulski M,Clark TA,Hon T,Jiao Y,Lu Z,Olson A,Stein JC,Ware D

更新日期：2016-06-24 00:00:00

abstract：:Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription...

journal_title：Nature communications

authors： Hasegawa S,Fukushima H,Hosoda H,Serita T,Ishikawa R,Rokukawa T,Kawahara-Miki R,Zhang Y,Ohta M,Okada S,Tanimizu T,Josselyn SA,Frankland PW,Kida S

更新日期：2019-12-18 00:00:00

abstract：:The magnetic excitations in the cuprate superconductors might be essential for an understanding of high-temperature superconductivity. In these cuprate superconductors the magnetic excitation spectrum resembles an hour-glass and certain resonant magnetic excitations within are believed to be connected to the pairing m...

journal_title：Nature communications

authors： Drees Y,Li ZW,Ricci A,Rotter M,Schmidt W,Lamago D,Sobolev O,Rütt U,Gutowski O,Sprung M,Piovano A,Castellan JP,Komarek AC

更新日期：2014-12-23 00:00:00

abstract：:Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 Å resolution single-particle cryo-electron microscopy structure of Mycobacteriu...

journal_title：Nature communications

authors： Tan YZ,Rodrigues J,Keener JE,Zheng RB,Brunton R,Kloss B,Giacometti SI,Rosário AL,Zhang L,Niederweis M,Clarke OB,Lowary TL,Marty MT,Archer M,Potter CS,Carragher B,Mancia F

更新日期：2020-07-07 00:00:00

abstract：:N(6)-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe(II)- and α-...

journal_title：Nature communications

authors： Fu Y,Jia G,Pang X,Wang RN,Wang X,Li CJ,Smemo S,Dai Q,Bailey KA,Nobrega MA,Han KL,Cui Q,He C

更新日期：2013-01-01 00:00:00

abstract：:Blends of electron-donating and -accepting organic semiconductors are widely used as photoactive materials in next-generation solar cells and photodetectors. The yield of free charges in these systems is often determined by the separation of interfacial electron-hole pairs, which is expected to depend on the ability o...

journal_title：Nature communications

authors： Stolterfoht M,Armin A,Shoaee S,Kassal I,Burn P,Meredith P

更新日期：2016-06-21 00:00:00

abstract：:Exploitation of the oxidation behaviour in an environmentally sensitive semiconductor is significant to modulate its electronic properties and develop unique applications. Here, we demonstrate a native oxidation-inspired InSe field-effect transistor as an artificial synapse in device level that benefits from the boost...

journal_title：Nature communications

authors： Yang FS,Li M,Lee MP,Ho IY,Chen JY,Ling H,Li Y,Chang JK,Yang SH,Chang YM,Lee KC,Chou YC,Ho CH,Li W,Lien CH,Lin YF

更新日期：2020-06-12 00:00:00

abstract：:Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) gene...

journal_title：Nature communications

authors： Takahashi H,Takigawa I,Watanabe M,Anwar D,Shibata M,Tomomori-Sato C,Sato S,Ranjan A,Seidel CW,Tsukiyama T,Mizushima W,Hayashi M,Ohkawa Y,Conaway JW,Conaway RC,Hatakeyama S

更新日期：2015-01-09 00:00:00

abstract：:Bacteria release membrane vesicles (MVs) that play important roles in various biological processes. However, the mechanisms of MV formation in Gram-positive bacteria are unclear, as these cells possess a single cytoplasmic membrane that is surrounded by a thick cell wall. Here we use live cell imaging and electron cry...

journal_title：Nature communications

authors： Toyofuku M,Cárcamo-Oyarce G,Yamamoto T,Eisenstein F,Hsiao CC,Kurosawa M,Gademann K,Pilhofer M,Nomura N,Eberl L

更新日期：2017-09-07 00:00:00

abstract：:Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Here we show that NK c...

journal_title：Nature communications

authors： Costanzo MC,Kim D,Creegan M,Lal KG,Ake JA,Currier JR,Streeck H,Robb ML,Michael NL,Bolton DL,Steers NJ,Eller MA

更新日期：2018-03-23 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Lee CH,Kang TH,Godon O,Watanabe M,Delidakis G,Gillis CM,Sterlin D,Hardy D,Cogné M,Macdonald LE,Murphy AJ,Tu N,Lee J,McDaniel JR,Makowski E,Tessier PM,Meyer AS,Bruhns P,Georgiou G

更新日期：2019-11-26 00:00:00

abstract：:Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell adaptor protein linke...

journal_title：Nature communications

authors： Raab M,Lu Y,Kohler K,Smith X,Strebhardt K,Rudd CE

更新日期：2017-07-12 00:00:00

abstract：:Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...

journal_title：Nature communications

authors： Artiglia L,Edebeli J,Orlando F,Chen S,Lee MT,Corral Arroyo P,Gilgen A,Bartels-Rausch T,Kleibert A,Vazdar M,Andres Carignano M,Francisco JS,Shepson PB,Gladich I,Ammann M

更新日期：2017-09-26 00:00:00

abstract：:URu2Si2 is one of the most enigmatic strongly correlated electron systems and offers a fertile testing ground for new concepts in condensed matter science. In spite of >30 years of intense research, no consensus on the order parameter of its low-temperature hidden-order phase exists. A strong magnetic field transforms...

journal_title：Nature communications

authors： Knafo W,Duc F,Bourdarot F,Kuwahara K,Nojiri H,Aoki D,Billette J,Frings P,Tonon X,Lelièvre-Berna E,Flouquet J,Regnault LP

更新日期：2016-10-20 00:00:00

abstract：:Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...

journal_title：Nature communications

authors： Endo K,Liu Y,Ube H,Nagata K,Shionoya M

更新日期：2020-12-09 00:00:00

abstract：:The world's coastal zones are experiencing rapid development and an increase in storms and flooding. These hazards put coastal communities at heightened risk, which may increase with habitat loss. Here we analyse globally the role and cost effectiveness of coral reefs in risk reduction. Meta-analyses reveal that coral...

journal_title：Nature communications

authors： Ferrario F,Beck MW,Storlazzi CD,Micheli F,Shepard CC,Airoldi L

更新日期：2014-05-13 00:00:00

abstract：:Various viruses enter host cells via endocytosis, but the molecular mechanisms underlying the specific internalization pathways remain unclear. Here we show that influenza A viruses (IAVs) enter cells via redundant pathways of clathrin-mediated and clathrin-independent endocytosis, with intracellular Ca(2+) having a c...

journal_title：Nature communications

authors： Fujioka Y,Tsuda M,Nanbo A,Hattori T,Sasaki J,Sasaki T,Miyazaki T,Ohba Y

更新日期：2013-01-01 00:00:00

abstract：:Artificial molecules containing just one or two electrons provide a powerful platform for studies of orbital and spin quantum dynamics in nanoscale devices. A well-known example of these dynamics is tunnelling of electrons between two coupled quantum dots triggered by mi...

journal_title：Nature communications

authors： Schreiber LR,Braakman FR,Meunier T,Calado V,Danon J,Taylor JM,Wegscheider W,Vandersypen LM

更新日期：2011-11-22 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:The turnover of messenger RNAs (mRNAs) is a key regulatory step of gene expression in eukaryotic cells. Due to the complexity of the mammalian degradation machinery, the contribution of decay factors to the directionality of mRNA decay is poorly understood. Here we characterize a molecular tool to interrogate mRNA tur...

journal_title：Nature communications

authors： Boehm V,Gerbracht JV,Marx MC,Gehring NH

更新日期：2016-12-05 00:00:00

abstract：:To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...

journal_title：Nature communications

authors： Chen M,Chen X,Schafer NP,Clementi C,Komives EA,Ferreiro DU,Wolynes PG

更新日期：2020-11-23 00:00:00

abstract：:Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl...

journal_title：Nature communications

authors： Nerli S,De Paula VS,McShan AC,Sgourakis NG

更新日期：2021-01-29 00:00:00

abstract：:The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R ant...

journal_title：Nature communications

authors： Yan H,Zhang X,Hu W,Ma J,Hou W,Zhang X,Wang X,Gao J,Shen Y,Lv J,Ohtsu H,Han F,Wang G,Chen Z

更新日期：2014-02-25 00:00:00

abstract：:We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a ...

journal_title：Nature communications

authors： New AM,Lehner B

更新日期：2019-08-14 00:00:00

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:Lithium metal is an ideal anode for lithium batteries due to its low electrochemical potential and high theoretical capacity. However, safety issues arising from lithium dendrite growth have significantly reduced the practical applicability of lithium metal batteries. Here, we report the addition of octaphenyl polyoxy...

journal_title：Nature communications

authors： Dai H,Gu X,Dong J,Wang C,Lai C,Sun S

更新日期：2020-01-31 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here...

journal_title：Nature communications

authors： Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier E

更新日期：2014-10-30 00:00:00

abstract：:This paper considers options for a future Indian power economy in which renewables, wind and solar, could meet 80% of anticipated 2040 power demand supplanting the country's current reliance on coal. Using a cost optimization model, here we show that renewables could provide a source of power cheaper or at least compe...

journal_title：Nature communications

authors： Lu T,Sherman P,Chen X,Chen S,Lu X,McElroy M

更新日期：2020-09-21 00:00:00

abstract：:Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals-and humans in particular-is the matter of controversial debate, mostly because the study of transgenerational ep...

journal_title：Nature communications

authors： Horsthemke B

更新日期：2018-07-30 00:00:00

abstract：:Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...

journal_title：Nature communications

authors： Loyd SJ,Sample J,Tripati RE,Defliese WF,Brooks K,Hovland M,Torres M,Marlow J,Hancock LG,Martin R,Lyons T,Tripati AE

更新日期：2016-07-22 00:00:00