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Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila.

Abstract：

:Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its overexpression in wild-type increases lifespan. Jouvence is required in enterocytes. In mutant, the epithelium of the gut presents more hyperplasia, while the overexpression of jouvence prevents it. Molecularly, the mutant lack pseudouridylation on 18S and 28S-rRNA, a function rescued by targeted expression of jouvence in the gut. A transcriptomic analysis performed from the gut reveals that several genes are either up- or down-regulated, while restoring the mRNA level of two genes (ninaD or CG6296) rescue the longevity. Since snoRNAs are structurally and functionally well conserved throughout evolution, we identified putative jouvence orthologue in mammals including humans, suggesting that its function in longevity could be conserved.

journal_name

Nat Commun

journal_title

Nature communications

authors

Soulé S,Mellottée L,Arab A,Chen C,Martin JR

doi

10.1038/s41467-020-14784-1

subject

Has Abstract

pub_date

2020-02-20 00:00:00

pages

987

issue

1

issn

2041-1723

pii

10.1038/s41467-020-14784-1

journal_volume

11

pub_type

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