Abstract：
:The bundle of stereocilia on inner ear hair cells responds to subnanometer deflections produced by sound or head movement. Stereocilia are interconnected by a variety of links and also carry an electron-dense surface coat. The coat may contribute to stereocilia adhesion or protect from stereocilia fusion, but its molecular identity remains unknown. From a database of hair-cell-enriched translated proteins, we identify Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1), a large, mostly extracellular protein of 4249 amino acids with a single transmembrane domain. Using serial immunogold scanning electron microscopy, we show that PKHD1L1 is expressed at the tips of stereocilia, especially in the high-frequency regions of the cochlea. PKHD1L1-deficient mice lack the surface coat at the upper but not lower regions of stereocilia, and they develop progressive hearing loss. We conclude that PKHD1L1 is a component of the surface coat and is required for normal hearing in mice.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wu X,Ivanchenko MV,Al Jandal H,Cicconet M,Indzhykulian AA,Corey DPdoi
10.1038/s41467-019-11712-wsubject
Has Abstractpub_date
2019-08-23 00:00:00pages
3801issue
1issn
2041-1723pii
10.1038/s41467-019-11712-wjournal_volume
10pub_type
杂志文章abstract：:The control of matter motion at liquid-gas interfaces opens an opportunity to create two-dimensional materials with remotely tunable properties. In analogy with optical lattices used in ultra-cold atom physics, such materials can be created by a wave field capable of dynamically guiding matter into periodic spatial st...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14325
更新日期：2017-02-09 00:00:00
abstract：:Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural k...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2484
更新日期：2013-01-01 00:00:00
abstract：:Proton conductive materials are of significant importance and highly desired for clean energy-related applications. Discovery of practical metal-organic frameworks (MOFs) with high proton conduction remains a challenge due to the use of toxic chemicals, inconvenient ligand preparation and complication of production at...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07414-4
更新日期：2018-11-22 00:00:00
abstract：:In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03545-w
更新日期：2018-03-28 00:00:00
abstract：:Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemne...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10498
更新日期：2016-02-15 00:00:00
abstract：:Dynamic processes have many implications in functional molecules, including catalysts, enzymes, host-guest complexes, and molecular machines. Here, we demonstrate via deuterium NMR relaxation experiments how halogen bonding directly impacts the dynamics in solid 2,3,5,6-tetramethylpyrazine cocrystals, catalyzing the m...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08878-8
更新日期：2019-02-22 00:00:00
abstract：:The original version of this Article contained an error in Fig. 4. In the lower part of the three gene circuit diagrams in panel b, the flat-headed arrow linking lambdaCI to the tetR promoter incorrectly pointed to the tetR gene body. This has now been corrected in the HTML and PDF versions of this Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-07844-0
更新日期：2019-01-08 00:00:00
abstract：:Recent years have witnessed the growing interest in the remote functionalization of alkenes for it offers a strategy to activate the challenging C-H bonds distant from the initiation point via alkene isomerization/functionalization. However, the catalytic enantioselective isomerization/functionalization with one singl...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06240-y
更新日期：2018-09-26 00:00:00
abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18943-2
更新日期：2020-10-13 00:00:00
abstract：:The biological pump transports organic carbon produced by photosynthesis to the meso- and bathypelagic zones, the latter removing carbon from exchanging with the atmosphere over centennial time scales. Organisms living in both zones are supported by a passive flux of particles, and carbon transported to the deep-sea t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19875-7
更新日期：2020-11-27 00:00:00
abstract：:Chemical utilization of vast fossil and renewable feedstocks of methane remains one of the most important challenges of modern chemistry. Herein, we report direct and selective methane photocatalytic oxidation at ambient conditions into carbon monoxide, which is an important chemical intermediate and a platform molecu...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08525-2
更新日期：2019-02-11 00:00:00
abstract：:As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, 18O...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13359-z
更新日期：2019-11-25 00:00:00
abstract：:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9737
更新日期：2015-10-28 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms14454. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms16007
更新日期：2017-06-23 00:00:00
abstract：:Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can also develop, resulting in relapse. Here we report a mechanism by which extrinsic resistance develops after local ablative radiation that relies on the immunosup...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01566-5
更新日期：2017-11-23 00:00:00
abstract：:Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00959-w
更新日期：2017-10-10 00:00:00
abstract：:Evidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attent...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10161
更新日期：2015-12-14 00:00:00
abstract：:Prompt identification of acute coronary syndrome is a challenge in clinical practice. The 12-lead electrocardiogram (ECG) is readily available during initial patient evaluation, but current rule-based interpretation approaches lack sufficient accuracy. Here we report machine learning-based methods for the prediction o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17804-2
更新日期：2020-08-07 00:00:00
abstract：:Anion-π interactions occur on the surface of π-acidic aromatic planes with positive quadrupole moments. Their ability to contribute to the binding and transport of anions has been demonstrated recently. However, their ability to stabilize anionic reactive intermediates and transition states remains essentially unexplo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4911
更新日期：2014-05-21 00:00:00
abstract：:Chemical functionalization is one of the most powerful and widely used strategies to control the properties of nanomaterials, particularly in the field of graphene. However, the ill-defined structure of the present functionalized graphene inhibits atomically precise structural characterization and structure-correlated...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3646
更新日期：2013-01-01 00:00:00
abstract：:Recent progress in nanotechnology enables the production of atomically abrupt interfaces in multilayered junctions, allowing for an increase in the number of transistors in a processor. However, uniform electron transport has not yet been achieved across the entire interfacial area in junctions due to the existence of...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12701
更新日期：2016-09-02 00:00:00
abstract：:Cavity optomechanics allows the characterization of a vibration mode, its cooling and quantum manipulation using electromagnetic fields. Regarding nanomechanical as well as electronic properties, single wall carbon nanotubes are a prototypical experimental system. At cryogenic temperatures, as high quality factor vibr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15433-3
更新日期：2020-04-02 00:00:00
abstract：:Currently, solar-thermal energy storage within phase-change materials relies on adding high thermal-conductivity fillers to improve the thermal-diffusion-based charging rate, which often leads to limited enhancement of charging speed and sacrificed energy storage capacity. Here we report the exploration of a magnetica...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01618-w
更新日期：2017-11-14 00:00:00
abstract：:Tunneling is a fundamental quantum process with no classical equivalent, which can compete with Coulomb interactions to give rise to complex phenomena. Phosphorus dopants in silicon can be placed with atomic precision to address the different regimes arising from this competition. However, they exploit wavefunctions r...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19835-1
更新日期：2020-11-30 00:00:00
abstract：:Matter-wave interferometry performed with massive objects elucidates their wave nature and thus tests the quantum superposition principle at large scales. Whereas standard quantum theory places no limit on particle size, alternative, yet untested theories--conceived to explain the apparent quantum to classical transit...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5788
更新日期：2014-09-02 00:00:00
abstract：:X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a dis...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05714-3
更新日期：2018-09-14 00:00:00
abstract：:Triboelectrification is a well-known phenomenon that commonly occurs in nature and in our lives at any time and any place. Although each and every material exhibits triboelectrification, its quantification has not been standardized. A triboelectric series has been qualitatively ranked with regards to triboelectric pol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09461-x
更新日期：2019-03-29 00:00:00
abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09794-7
更新日期：2019-04-23 00:00:00
abstract：:Genomic evidence is increasingly underpinning that hybridization between taxa is commonplace, challenging our views on the mechanisms that maintain their boundaries. Here, we focus on seven catadromous eel species (genus Anguilla) and use genome-wide sequence data from more than 450 individuals sampled across the trop...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15099-x
更新日期：2020-03-18 00:00:00
abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12992
更新日期：2016-10-05 00:00:00
