Abstract:
:This corrects the article DOI: 10.1038/ncomms14454.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bengtsson NE,Hall JK,Odom GL,Phelps MP,Andrus CR,Hawkins RD,Hauschka SD,Chamberlain JR,Chamberlain JSdoi
10.1038/ncomms16007subject
Has Abstractpub_date
2017-06-23 00:00:00pages
16007issn
2041-1723pii
ncomms16007journal_volume
8pub_type
杂志文章,已发布勘误abstract::To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7255
更新日期:2015-02-17 00:00:00
abstract::Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8125
更新日期:2015-05-21 00:00:00
abstract::Carbon forms one of nature's strongest chemical bonds; its allotropes having provided some of the most exciting scientific discoveries in recent times. The possibility of inter-allotropic transformations/hybridization of carbon is hence a topic of immense fundamental and technological interest. Such modifications usua...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5941
更新日期:2014-09-15 00:00:00
abstract::The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16796-3
更新日期:2020-06-11 00:00:00
abstract::Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01195-y
更新日期:2017-10-24 00:00:00
abstract::Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00266-4
更新日期:2017-08-04 00:00:00
abstract::Meso/micro-porous solids, such as zeolites, are complex materials used in an impressive range of applications. Here we photo-polymerized ethylene using non-catalytic high-pressure techniques at 0.5-1.5 GPa under ultraviolet (351-364 nm) irradiation on a sub-nanometre scale in the channels of a pure SiO2 zeolite, silic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2564
更新日期:2013-01-01 00:00:00
abstract::In the original version of this Article, extraneous text not belonging to the Article was accidentally appended to the results section. This error has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04279-5
更新日期:2018-05-08 00:00:00
abstract::Controlling the properties of quantum dots at the atomic scale, such as dangling bonds, is a general motivation as they allow studying various nanoscale processes including atomic switches, charge storage, or low binding energy state interactions. Adjusting the coupling of individual silicon dangling bonds to form a 2...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02377-4
更新日期:2017-12-20 00:00:00
abstract::Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13554-y
更新日期:2019-12-18 00:00:00
abstract::Biological cellular structures have inspired many scientific disciplines to design synthetic structures that can mimic their functions. Here, we closely emulate biological cellular structures in a rationally designed synthetic multicellular hybrid ion pump, composed of hydrogen-bonded [EMIM+][TFSI-] ion pairs on the s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11973-5
更新日期:2019-09-05 00:00:00
abstract::The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-spec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12397
更新日期:2016-08-03 00:00:00
abstract::The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule struc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17141-4
更新日期:2020-07-03 00:00:00
abstract::Photovoltaic devices based on metal halide perovskites are rapidly improving in efficiency. Once the Shockley-Queisser limit is reached, charge-carrier extraction will be limited only by radiative bimolecular recombination of electrons with holes. Yet, this fundamental process, and its link with material stoichiometry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02670-2
更新日期:2018-01-18 00:00:00
abstract::Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19331-6
更新日期:2020-10-30 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) gen...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-16711-w
更新日期:2020-06-24 00:00:00
abstract::Large-scale climate patterns control variability in the global carbon sink. In Europe, the North-Atlantic Oscillation (NAO) influences vegetation activity, however the East-Atlantic (EA) pattern is known to modulate NAO strength and location. Using observation-driven and modelled data sets, we show that multi-annual v...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10315
更新日期:2016-01-18 00:00:00
abstract::Enantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01099-x
更新日期:2017-11-09 00:00:00
abstract::Preterm infants exhibit different microbiome colonization patterns relative to full-term infants, and it is speculated that the hospital room environment may contribute to infant microbiome development. Here, we present a genome-resolved metagenomic study of microbial genotypes from the gastrointestinal tracts of infa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02018-w
更新日期:2017-11-27 00:00:00
abstract::Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary to this view, we show here that TLR7 is present on the cell surface of immune cells and that TLR7 responses can be inhib...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7119
更新日期:2015-02-04 00:00:00
abstract::Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9737
更新日期:2015-10-28 00:00:00
abstract::Microbial biofilm formation on indwelling medical devices causes persistent infections that cannot be cured with conventional antibiotics. To address this unmet challenge, we engineer tunable active surface topographies with micron-sized pillars that can beat at a programmable frequency and force level in an electroma...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16055-5
更新日期:2020-05-05 00:00:00
abstract::Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18422-8
更新日期:2020-09-15 00:00:00
abstract::We are constantly interacting with our environment whilst we encode memories. However, how actions influence memory formation remains poorly understood. Goal-directed movement engages the locus coeruleus (LC), the main source of noradrenaline in the brain. Noradrenaline is also known to enhance episodic encoding, sugg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11358-8
更新日期:2019-08-06 00:00:00
abstract::Sex differences exist in behaviors, disease and neuropsychiatric disorders. Sexual dimorphisms however, have yet to be studied across the whole brain and across a comprehensive time course of postnatal development. Here, we use manganese-enhanced MRI (MEMRI) to longitudinally image male and female C57BL/6J mice across...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04921-2
更新日期:2018-07-05 00:00:00
abstract::Normalization is a common cortical computation widely observed in sensory perception, but its importance in perception of reward value and decision making remains largely unknown. We examined (1) whether normalized value signals occur in the orbitofrontal cortex (OFC) and (2) whether changes in behavioral task context...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02614-w
更新日期:2018-01-11 00:00:00
abstract::The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05220-6
更新日期:2018-07-24 00:00:00
abstract::As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7893
更新日期:2015-04-20 00:00:00
abstract::Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04469-1
更新日期:2018-05-22 00:00:00
abstract::Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct enantioselective C-H amination to access optically pure N-C atropisomer is still difficult and rare. Here we report a π-π interaction and dual H-bond concerted control s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10858-x
更新日期:2019-07-11 00:00:00