Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.

abstract：:TFIIS-like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA polymerases. Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into a potent RNA polymerase inhibitor. TFS4 destabilises the TBP-TFB-RNAP pre-initiation com...

journal_title：Nature communications

authors： Fouqueau T,Blombach F,Hartman R,Cheung ACM,Young MJ,Werner F

更新日期：2017-12-04 00:00:00

abstract：:Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of ...

journal_title：Nature communications

authors： Chen Y,Siegel F,Kipschull S,Haas B,Fröhlich H,Meister G,Pfeifer A

更新日期：2013-01-01 00:00:00

abstract：:Irrigated agriculture has important implications for achieving the United Nations Sustainable Development Goals. However, there is a lack of systematic and quantitative analyses of its impacts on food-energy-water-CO2 nexus. Here we studied impacts of irrigated agriculture on food-energy-water-CO2 nexus across food se...

journal_title：Nature communications

authors： Xu Z,Chen X,Liu J,Zhang Y,Chau S,Bhattarai N,Wang Y,Li Y,Connor T,Li Y

更新日期：2020-11-17 00:00:00

abstract：:Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere. Although these cold winters are thought to be partly driven by dramatic losses of Arctic sea-ice, the mechanism that links sea-ice loss to cold w...

journal_title：Nature communications

authors： Kim BM,Son SW,Min SK,Jeong JH,Kim SJ,Zhang X,Shim T,Yoon JH

更新日期：2014-09-02 00:00:00

abstract：:Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female p...

journal_title：Nature communications

authors： Vazquez MJ,Toro CA,Castellano JM,Ruiz-Pino F,Roa J,Beiroa D,Heras V,Velasco I,Dieguez C,Pinilla L,Gaytan F,Nogueiras R,Bosch MA,Rønnekleiv OK,Lomniczi A,Ojeda SR,Tena-Sempere M

更新日期：2018-10-10 00:00:00

abstract：:Nonribosomal peptide synthetases containing starter condensation domains direct the biosynthesis of nonribosomal lipopeptides, which generally exhibit wide bioactivities. The acyl chain has strong impacts on bioactivity and toxicity, but the lack of an in-depth understanding of starter condensation domain-mediated lip...

journal_title：Nature communications

authors： Zhong L,Diao X,Zhang N,Li F,Zhou H,Chen H,Bai X,Ren X,Zhang Y,Wu D,Bian X

更新日期：2021-01-12 00:00:00

abstract：:Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

journal_title：Nature communications

authors： Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

更新日期：2017-01-27 00:00:00

abstract：:Unusual features of the vibrational density of states D(ω) of glasses allow one to rationalize their peculiar low-temperature properties. Simulational studies of D(ω) have been restricted to studying poorly annealed glasses that may not be relevant to experiments. Here we report on D(ω) of zero-temperature glasses wit...

journal_title：Nature communications

authors： Wang L,Ninarello A,Guan P,Berthier L,Szamel G,Flenner E

更新日期：2019-01-03 00:00:00

abstract：:Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable processes....

journal_title：Nature communications

authors： Bertolani A,Pirrie L,Stefan L,Houbenov N,Haataja JS,Catalano L,Terraneo G,Giancane G,Valli L,Milani R,Ikkala O,Resnati G,Metrangolo P

更新日期：2015-06-30 00:00:00

abstract：:Genetic studies of Neolithic and Bronze Age skeletons from Europe have provided evidence for strong population genetic changes at the beginning and the end of the Neolithic period. To further understand the implications of these in Southern Central Europe, we analyze 96 ancient genomes from Switzerland, Southern Germa...

journal_title：Nature communications

authors： Furtwängler A,Rohrlach AB,Lamnidis TC,Papac L,Neumann GU,Siebke I,Reiter E,Steuri N,Hald J,Denaire A,Schnitzler B,Wahl J,Ramstein M,Schuenemann VJ,Stockhammer PW,Hafner A,Lösch S,Haak W,Schiffels S,Krause J

更新日期：2020-04-20 00:00:00

abstract：:Manipulation of nonlinear waves in artificial periodic structures leads to spectacular spatial features, such as generation of gap solitons or onset of the Mott insulator phase transition. Cavity exciton-polaritons are strongly interacting quasiparticles offering large possibilities for potential optical technologies....

journal_title：Nature communications

authors： Tanese D,Flayac H,Solnyshkov D,Amo A,Lemaître A,Galopin E,Braive R,Senellart P,Sagnes I,Malpuech G,Bloch J

更新日期：2013-01-01 00:00:00

abstract：:Thin-film transistor (TFT)-driven full-color organic light-emitting diodes (OLEDs) with vertically stacked structures are developed herein using photolithography processes, which allow for high-resolution displays of over 2,000 pixels per inch. Vertical stacking of OLEDs by the photolithography process is technically ...

journal_title：Nature communications

authors： Choi S,Kang CM,Byun CW,Cho H,Kwon BH,Han JH,Yang JH,Shin JW,Hwang CS,Cho NS,Lee KM,Kim HO,Kim E,Yoo S,Lee H

更新日期：2020-06-01 00:00:00

abstract：:Deep subwavelength features are expected to have minimal impact on wave transport. Here we show that in contrast to this common understanding, disorder can have a dramatic effect in a one-dimensional disordered optical system with spatial features a thousand times smaller than the wavelength. We examine a unique regim...

journal_title：Nature communications

authors： Herzig Sheinfux H,Kaminer I,Genack AZ,Segev M

更新日期：2016-10-06 00:00:00

abstract：:16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...

journal_title：Nature communications

authors： Moreau CA,Urchs SGW,Kuldeep K,Orban P,Schramm C,Dumas G,Labbe A,Huguet G,Douard E,Quirion PO,Lin A,Kushan L,Grot S,Luck D,Mendrek A,Potvin S,Stip E,Bourgeron T,Evans AC,Bearden CE,Bellec P,Jacquemont S

更新日期：2020-10-19 00:00:00

abstract：:Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...

journal_title：Nature communications

authors： Gao N,He Y,Tao X,Xu XQ,Wu X,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...

journal_title：Nature communications

authors： Xu S,Zhan M,Jiang C,He M,Yang L,Shen H,Huang S,Huang X,Lin R,Shi Y,Liu Q,Chen W,Mohan M,Wang J

更新日期：2019-12-02 00:00:00

abstract：:Eastern Beringia is one of the few Western Arctic regions where full Holocene climate reconstructions are possible. However, most full Holocene reconstructions in Eastern Beringia are based either on pollen or midges, which show conflicting early Holocene summer temperature histories. This discrepancy precludes unders...

journal_title：Nature communications

authors： Porter TJ,Schoenemann SW,Davies LJ,Steig EJ,Bandara S,Froese DG

更新日期：2019-04-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Osuna-Cruz CM,Bilcke G,Vancaester E,De Decker S,Bones AM,Winge P,Poulsen N,Bulankova P,Verhelst B,Audoor S,Belisova D,Pargana A,Russo M,Stock F,Cirri E,Brembu T,Pohnert G,Piganeau G,Ferrante MI,Mock T,Sterck L,S

更新日期：2020-10-16 00:00:00

abstract：:Magmatic intrusions and volcanic eruptions are intimately related phenomena. Shallow magma intrusion builds subsurface reservoirs that are drained by volcanic eruptions. Thus, the long-held view is that intrusions must precede and feed eruptions. Here we show that explosive eruptions can also cause magma intrusion. We...

journal_title：Nature communications

authors： Castro JM,Cordonnier B,Schipper CI,Tuffen H,Baumann TS,Feisel Y

更新日期：2016-11-23 00:00:00

abstract：:Saturn's largest moon Titan has a substantial nitrogen-methane atmosphere, with strong seasonal effects, including formation of winter polar vortices. Following Titan's 2009 northern spring equinox, peak solar heating moved to the northern hemisphere, initiating south-polar subsidence and winter polar vortex formation...

journal_title：Nature communications

authors： Teanby NA,Bézard B,Vinatier S,Sylvestre M,Nixon CA,Irwin PGJ,de Kok RJ,Calcutt SB,Flasar FM

更新日期：2017-11-21 00:00:00

abstract：:The Ångström-sized probe of the scanning transmission electron microscope can visualize and collect spectra from single atoms. This can unambiguously resolve the chemical structure of materials, but not their isotopic composition. Here we differentiate between two isotopes of the same element by quantifying how likely...

journal_title：Nature communications

authors： Susi T,Hofer C,Argentero G,Leuthner GT,Pennycook TJ,Mangler C,Meyer JC,Kotakoski J

更新日期：2016-10-10 00:00:00

abstract：:Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin driven by processive hydrolysis of single chitin chain. Here, we analyse the mechanism underlying unidirectional movement of Serratia marcescens chitinase A (SmChiA) using high-precision single-molecule imaging, X-ray cry...

journal_title：Nature communications

authors： Nakamura A,Okazaki KI,Furuta T,Sakurai M,Iino R

更新日期：2018-09-19 00:00:00

abstract：:Linking microbial metabolomics and carbon sequestration in the ocean via refractory organic molecules has been hampered by the chemical complexity of dissolved organic matter (DOM). Here, using bioassay experiments and ultra-high resolution metabolic profiling, we demonstrate that marine bacteria rapidly utilize simpl...

journal_title：Nature communications

authors： Lechtenfeld OJ,Hertkorn N,Shen Y,Witt M,Benner R

更新日期：2015-03-31 00:00:00

abstract：:The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated durin...

journal_title：Nature communications

authors： Wang L,Wang S,Shi Y,Li R,Günther S,Ong YT,Potente M,Yuan Z,Liu E,Offermanns S

更新日期：2020-10-28 00:00:00

abstract：:Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural crest migration are comparatively unknown, due to difficulties accessing this cell population in vivo. Here we report requirements of glycogen synthase kinase 3 (GSK3) in regulating the neural crest in Xenopus and...

journal_title：Nature communications

authors： Gonzalez Malagon SG,Lopez Muñoz AM,Doro D,Bolger TG,Poon E,Tucker ER,Adel Al-Lami H,Krause M,Phiel CJ,Chesler L,Liu KJ

更新日期：2018-03-19 00:00:00

abstract：:Primary microcephaly (MCPH) is characterized by reduced brain size and intellectual disability. The exact pathophysiological mechanism underlying MCPH remains to be elucidated, but dysfunction of neuronal progenitors in the developing neocortex plays a major role. We identified a homozygous missense mutation (p.W155C)...

journal_title：Nature communications

authors： Farooq M,Lindbæk L,Krogh N,Doganli C,Keller C,Mönnich M,Gonçalves AB,Sakthivel S,Mang Y,Fatima A,Andersen VS,Hussain MS,Eiberg H,Hansen L,Kjaer KW,Gopalakrishnan J,Pedersen LB,Møllgård K,Nielsen H,Baig SM,Tommerup

更新日期：2020-11-16 00:00:00

abstract：:In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and the production of s...

journal_title：Nature communications

authors： Pérez-García A,Marina-Zárate E,Álvarez-Prado ÁF,Ligos JM,Galjart N,Ramiro AR

更新日期：2017-07-05 00:00:00

abstract：:Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...

journal_title：Nature communications

authors： Zhang L,Zhang X,Tian G,Zhang Q,Knapp M,Ehrenberg H,Chen G,Shen Z,Yang G,Gu L,Du F

更新日期：2020-07-13 00:00:00

abstract：:Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. In contrast to the performance of excitatory rhodopsins, the effectiveness of inhibitory optogenetic tools is still insufficient. Here we report a t...

journal_title：Nature communications

authors： Bernal Sierra YA,Rost BR,Pofahl M,Fernandes AM,Kopton RA,Moser S,Holtkamp D,Masala N,Beed P,Tukker JJ,Oldani S,Bönigk W,Kohl P,Baier H,Schneider-Warme F,Hegemann P,Beck H,Seifert R,Schmitz D

更新日期：2018-11-05 00:00:00

abstract：:Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...

journal_title：Nature communications

authors： Li J,Sanz S,Corso M,Choi DJ,Peña D,Frederiksen T,Pascual JI

更新日期：2019-01-14 00:00:00