Abstract:
:Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Notti RQ,Bhattacharya S,Lilic M,Stebbins CEdoi
10.1038/ncomms8125subject
Has Abstractpub_date
2015-05-21 00:00:00pages
7125issn
2041-1723pii
ncomms8125journal_volume
6pub_type
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