Nanoscale π-π stacked molecules are bound by collective charge fluctuations.

abstract：:For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that inte...

journal_title：Nature communications

authors： Nordenfelt P,Elliott HL,Springer TA

更新日期：2016-10-10 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00

abstract：:Acenes are an important class of polycyclic aromatic hydrocarbons which have recently gained exceptional attention due to their potential as functional organic semiconductors. Fundamentally, they are important systems to study the convergence of physico-chemical properties of all-carbon sp2-frameworks in the one-dimen...

journal_title：Nature communications

authors： Urgel JI,Mishra S,Hayashi H,Wilhelm J,Pignedoli CA,Di Giovannantonio M,Widmer R,Yamashita M,Hieda N,Ruffieux P,Yamada H,Fasel R

更新日期：2019-02-20 00:00:00

abstract：:Despite centuries of research, much about the barbarian migrations that took place between the fourth and sixth centuries in Europe remains hotly debated. To better understand this key era that marks the dawn of modern European societies, we obtained ancient genomic DNA from 63 samples from two cemeteries (from Hungar...

journal_title：Nature communications

authors： Amorim CEG,Vai S,Posth C,Modi A,Koncz I,Hakenbeck S,La Rocca MC,Mende B,Bobo D,Pohl W,Baricco LP,Bedini E,Francalacci P,Giostra C,Vida T,Winger D,von Freeden U,Ghirotto S,Lari M,Barbujani G,Krause J,Caramelli D

更新日期：2018-09-11 00:00:00

abstract：:The space charge layer (SCL) is generally considered one of the origins of the sluggish interfacial lithium-ion transport in all-solid-state lithium-ion batteries (ASSLIBs). However, in-situ visualization of the SCL effect on the interfacial lithium-ion transport in sulfide-based ASSLIBs is still a great challenge. He...

journal_title：Nature communications

authors： Wang L,Xie R,Chen B,Yu X,Ma J,Li C,Hu Z,Sun X,Xu C,Dong S,Chan TS,Luo J,Cui G,Chen L

更新日期：2020-11-18 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

journal_title：Nature communications

authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

更新日期：2018-10-01 00:00:00

abstract：:The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding ...

journal_title：Nature communications

authors： Qi S,Li Z,Schulze-Gahmen U,Stjepanovic G,Zhou Q,Hurley JH

更新日期：2017-01-30 00:00:00

abstract：:The successful mitigation of emerging wildlife diseases may involve controversial host culling. For livestock, 'preemptive host culling' is an accepted practice involving the removal of herds with known contact to infected populations. When applied to wildlife, this proactive approach comes in conflict with biodiversi...

journal_title：Nature communications

authors： Mysterud A,Hopp P,Alvseike KR,Benestad SL,Nilsen EB,Rolandsen CM,Strand O,Våge J,Viljugrein H

更新日期：2020-09-01 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:Time-resolved photoelectron spectroscopy (TRPES) is a useful approach to elucidate the coupled electronic-nuclear quantum dynamics underlying chemical processes, but has remained limited by the use of low photon energies. Here, we demonstrate the general advantages of XUV-TRPES through an application to NO2, one of th...

journal_title：Nature communications

authors： von Conta A,Tehlar A,Schletter A,Arasaki Y,Takatsuka K,Wörner HJ

更新日期：2018-08-08 00:00:00

abstract：:Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...

journal_title：Nature communications

authors： Garcia-Basteiro AL,Moncunill G,Tortajada M,Vidal M,Guinovart C,Jiménez A,Santano R,Sanz S,Méndez S,Llupià A,Aguilar R,Alonso S,Barrios D,Carolis C,Cisteró P,Chóliz E,Cruz A,Fochs S,Jairoce C,Hecht J,Lamoglia M,M

更新日期：2020-07-08 00:00:00

abstract：:The trade-offs between photoelectrode efficiency and stability significantly hinder the practical application of silicon-based photoelectrochemical devices. Here, we report a facile approach to decouple the trade-offs of silicon-based photocathodes by employing crystalline TiO2 with graded oxygen defects as protection...

journal_title：Nature communications

authors： Zheng J,Lyu Y,Wang R,Xie C,Zhou H,Jiang SP,Wang S

更新日期：2018-09-03 00:00:00

abstract：:Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...

journal_title：Nature communications

authors： Feng X,Hsu SJ,Bhattacharjee A,Wang Y,Diao J,Price CM

更新日期：2018-07-19 00:00:00

abstract：:During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...

journal_title：Nature communications

authors： Kale GR,Yang X,Philippe JM,Mani M,Lenne PF,Lecuit T

更新日期：2018-11-27 00:00:00

abstract：:Despite the lack of a layered neocortex and fundamental differences in endbrain organization in birds compared with mammals, intelligent species evolved from both vertebrate classes. Among birds, corvids show exceptional cognitive flexibility. Here we explore the neuronal foundation of corvid cognition by recording si...

journal_title：Nature communications

authors： Veit L,Nieder A

更新日期：2013-01-01 00:00:00

abstract：:How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...

journal_title：Nature communications

authors： Seibt J,Richard CJ,Sigl-Glöckner J,Takahashi N,Kaplan DI,Doron G,de Limoges D,Bocklisch C,Larkum ME

更新日期：2017-09-25 00:00:00

abstract：:Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs....

journal_title：Nature communications

authors： Ishihara H,Sugimoto K,Tarr PT,Temman H,Kadokura S,Inui Y,Sakamoto T,Sasaki T,Aida M,Suzuki T,Inagaki S,Morohashi K,Seki M,Kakutani T,Meyerowitz EM,Matsunaga S

更新日期：2019-04-16 00:00:00

abstract：:Single-crystal cathode materials for lithium-ion batteries have attracted increasing interest in providing greater capacity retention than their polycrystalline counterparts. However, after being cycled at high voltages, these single-crystal materials exhibit severe structural instability and capacity fade. Understand...

journal_title：Nature communications

authors： Zhang F,Lou S,Li S,Yu Z,Liu Q,Dai A,Cao C,Toney MF,Ge M,Xiao X,Lee WK,Yao Y,Deng J,Liu T,Tang Y,Yin G,Lu J,Su D,Wang J

更新日期：2020-06-16 00:00:00

abstract：:One of the fundamental challenges in nanophotonics is to gain full control over nanoscale optical elements. The precise spatiotemporal arrangement determines their interactions and collective behavior. To this end, DNA nanotechnology is employed as an unprecedented tool to create nanophotonic devices with excellent sp...

journal_title：Nature communications

authors： Xin L,Zhou C,Duan X,Liu N

更新日期：2019-11-27 00:00:00

abstract：:Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...

journal_title：Nature communications

authors： Berthier L,Charbonneau P,Ninarello A,Ozawa M,Yaida S

更新日期：2019-04-03 00:00:00

abstract：:Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...

journal_title：Nature communications

authors： Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztei

更新日期：2019-04-18 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and last out to at least one month post-injury. To investigate a mechan...

journal_title：Nature communications

authors： Bolte AC,Dutta AB,Hurt ME,Smirnov I,Kovacs MA,McKee CA,Ennerfelt HE,Shapiro D,Nguyen BH,Frost EL,Lammert CR,Kipnis J,Lukens JR

更新日期：2020-09-10 00:00:00

abstract：:The worldwide dissemination of metallo-β-lactamases (MBLs), mediating resistance to carbapenem antibiotics, is a major public health problem. The extent of dissemination of MBLs such as VIM-2, SPM-1 and NDM among Gram-negative pathogens cannot be explained solely based on the associated mobile genetic elements or the ...

journal_title：Nature communications

authors： López C,Ayala JA,Bonomo RA,González LJ,Vila AJ

更新日期：2019-08-09 00:00:00

abstract：:Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for ...

journal_title：Nature communications

authors： Antony AN,Paillard M,Moffat C,Juskeviciute E,Correnti J,Bolon B,Rubin E,Csordás G,Seifert EL,Hoek JB,Hajnóczky G

更新日期：2016-03-09 00:00:00

abstract：:We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scannin...

journal_title：Nature communications

authors： Lin L,Hu P,Shi J,Appleton CM,Maslov K,Li L,Zhang R,Wang LV

更新日期：2018-06-15 00:00:00

abstract：:Directed self-assemblies in water are known as the most efficient means of forming complex higher ordered structures in nature. Here we show a straightforward and robust method for particle assembly which utilises the amphiphilic tri-block co-polymer poloxamer-188 and a hydrophobic fluorophore as the two designer comp...

journal_title：Nature communications

authors： Cheung S,O'Shea DF

更新日期：2017-12-01 00:00:00

abstract：:Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism and tumor development remains poorly defined. Here, we show that upon glucose intake, the splicing factor SRSF5 is specifically induced...

journal_title：Nature communications

authors： Chen Y,Huang Q,Liu W,Zhu Q,Cui CP,Xu L,Guo X,Wang P,Liu J,Dong G,Wei W,Liu CH,Feng Z,He F,Zhang L

更新日期：2018-06-25 00:00:00

abstract：:Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...

journal_title：Nature communications

authors： Galbraith MCE,Scheit S,Golubev NV,Reitsma G,Zhavoronkov N,Despré V,Lépine F,Kuleff AI,Vrakking MJJ,Kornilov O,Köppel H,Mikosch J

更新日期：2017-10-18 00:00:00

abstract：:Long-range chromatin interactions are important for transcriptional regulation of genes, many of which are related to complex agronomics traits. However, the pattern of three-dimensional chromatin interactions remains unclear in plants. Here we report the generation of chromatin interaction analysis by paired-end tag ...

journal_title：Nature communications

authors： Li E,Liu H,Huang L,Zhang X,Dong X,Song W,Zhao H,Lai J

更新日期：2019-06-14 00:00:00

abstract：:Targeting the vasculature remains a promising approach for treating solid tumours; however, the mechanisms of tumour neovascularization are diverse and complex. Here we uncover a new subpopulation of melanoma cells that express the vascular cell adhesion molecule PECAM1, but not VEGFR-2, and participate in a PECAM1-de...

journal_title：Nature communications

authors： Dunleavey JM,Xiao L,Thompson J,Kim MM,Shields JM,Shelton SE,Irvin DM,Brings VE,Ollila DW,Brekken RA,Dayton PA,Melero-Martin JM,Dudley AC

更新日期：2014-10-22 00:00:00