Hunting strategies to increase detection of chronic wasting disease in cervids.

abstract：:Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease...

journal_title：Nature communications

authors： Raveney BJ,Oki S,Hohjoh H,Nakamura M,Sato W,Murata M,Yamamura T

更新日期：2015-10-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Macreadie PI,Anton A,Raven JA,Beaumont N,Connolly RM,Friess DA,Kelleway JJ,Kennedy H,Kuwae T,Lavery PS,Lovelock CE,Smale DA,Apostolaki ET,Atwood TB,Baldock J,Bianchi TS,Chmura GL,Eyre BD,Fourqurean JW,Hall-Spencer J

更新日期：2019-11-08 00:00:00

abstract：:Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover that nucleophosmin (NPM1) binds to PD-L1 promoter...

journal_title：Nature communications

authors： Qin G,Wang X,Ye S,Li Y,Chen M,Wang S,Qin T,Zhang C,Li Y,Long Q,Hu H,Shi D,Li J,Zhang K,Zhai Q,Tang Y,Kang T,Lan P,Xie F,Lu J,Deng W

更新日期：2020-04-03 00:00:00

abstract：:Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transformation is stimulus-dependent. We employ in vivo whole-cell recordings ...

journal_title：Nature communications

authors： Kim KX,Atencio CA,Schreiner CE

更新日期：2020-02-27 00:00:00

abstract：:Chloroplasts communicate information by signalling to nuclei during acclimation to fluctuating light. Several potential operating signals originating from chloroplasts have been proposed, but none have been shown to move to nuclei to modulate gene expression. One proposed signal is hydrogen peroxide (H2O2) produced by...

journal_title：Nature communications

authors： Exposito-Rodriguez M,Laissue PP,Yvon-Durocher G,Smirnoff N,Mullineaux PM

更新日期：2017-06-29 00:00:00

abstract：:Highly sensitive and specific non-invasive molecular imaging methods are particularly desirable for the early detection of cancers. Here we report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment to detect tumour and cancer cells with the sensitivity to a few thousands cance...

journal_title：Nature communications

authors： Zheng X,Wang X,Mao H,Wu W,Liu B,Jiang X

更新日期：2015-01-05 00:00:00

abstract：:Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a protective role against the development of disease. Elevated IL-36 cytokine expression is found i...

journal_title：Nature communications

authors： Giannoudaki E,Hernandez-Santana YE,Mulfaul K,Doyle SL,Hams E,Fallon PG,Mat A,O'Shea D,Kopf M,Hogan AE,Walsh PT

更新日期：2019-09-05 00:00:00

abstract：:Urbanisation is an important global driver of biodiversity change, negatively impacting some species groups whilst providing opportunities for others. Yet its impact on ecosystem services is poorly investigated. Here, using a replicated experimental design, we test how Central European cities impact flying insects and...

journal_title：Nature communications

authors： Theodorou P,Radzevičiūtė R,Lentendu G,Kahnt B,Husemann M,Bleidorn C,Settele J,Schweiger O,Grosse I,Wubet T,Murray TE,Paxton RJ

更新日期：2020-01-29 00:00:00

abstract：:Human Bestrophin1 (hBest1) is a Ca2+-activated Cl- channel in retinal pigment epithelium (RPE) essential for retina physiology, and its mutation results in retinal degenerative diseases that have no available treatments. Here, we discover that hBest1's channel activity in human RPE is significantly enhanced by adenosi...

journal_title：Nature communications

authors： Zhang Y,Kittredge A,Ward N,Ji C,Chen S,Yang T

更新日期：2018-08-07 00:00:00

abstract：:Bell correlations are a foundational demonstration of how quantum entanglement contradicts the classical notion of local realism. Rigorous validation of quantum nonlocality have only been achieved between solid-state electron spins, internal states of trapped atoms, and photon polarisations, all weakly coupling to gra...

journal_title：Nature communications

authors： Shin DK,Henson BM,Hodgman SS,Wasak T,Chwedeńczuk J,Truscott AG

更新日期：2019-10-01 00:00:00

abstract：:Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...

journal_title：Nature communications

authors： Wallin G,Kamerlin SC,Aqvist J

更新日期：2013-01-01 00:00:00

abstract：:Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we repo...

journal_title：Nature communications

authors： Zhu X,Guo Y,Cheng H,Dai J,An X,Zhao J,Tian K,Wei S,Cheng Zeng X,Wu C,Xie Y

更新日期：2016-04-04 00:00:00

abstract：:β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting common...

journal_title：Nature communications

authors： Bende NS,Dziemborowicz S,Mobli M,Herzig V,Gilchrist J,Wagner J,Nicholson GM,King GF,Bosmans F

更新日期：2014-07-11 00:00:00

abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

journal_title：Nature communications

authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

更新日期：2012-05-01 00:00:00

abstract：:Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocr...

journal_title：Nature communications

authors： Stone A,Zotenko E,Locke WJ,Korbie D,Millar EK,Pidsley R,Stirzaker C,Graham P,Trau M,Musgrove EA,Nicholson RI,Gee JM,Clark SJ

更新日期：2015-07-14 00:00:00

abstract：:Supersymmetry is a conjectured symmetry between bosons and fermions aiming at solving fundamental questions in string and quantum field theory. Its subsequent application to quantum mechanics led to a ground-breaking analysis and design machinery, later fruitfully extrapolated to photonics. In all cases, the algebraic...

journal_title：Nature communications

authors： García-Meca C,Ortiz AM,Sáez RL

更新日期：2020-02-10 00:00:00

abstract：:In magnetic materials, the Pauli exclusion principle typically drives anti-alignment between electron spins on neighbouring species resulting in antiferromagnetic behaviour. Ferromagnetism exhibiting spontaneous spin alignment is a fairly rare behaviour, but once materialized is often associated with itinerant electro...

journal_title：Nature communications

authors： Bristowe NC,Varignon J,Fontaine D,Bousquet E,Ghosez P

更新日期：2015-03-25 00:00:00

abstract：:Catalytic C-H activation and hydroamination represent two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced waste production. Combining both C-H activation and hydroamination in a cascade process, preferably with a single catalyst, would allow rapid access to valuable nitro...

journal_title：Nature communications

authors： Manan RS,Zhao P

更新日期：2016-06-20 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00

abstract：:The electronic properties of graphene are described by a Dirac Hamiltonian with a four-fold symmetry of spin and valley. This symmetry may yield novel fractional quantum Hall (FQH) states at high magnetic field depending on the relative strength of symmetry-breaking interactions. However, observing such states in tran...

journal_title：Nature communications

authors： Amet F,Bestwick AJ,Williams JR,Balicas L,Watanabe K,Taniguchi T,Goldhaber-Gordon D

更新日期：2015-01-06 00:00:00

abstract：:Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...

journal_title：Nature communications

authors： Boivin G,Faget J,Ancey PB,Gkasti A,Mussard J,Engblom C,Pfirschke C,Contat C,Pascual J,Vazquez J,Bendriss-Vermare N,Caux C,Vozenin MC,Pittet MJ,Gunzer M,Meylan E

更新日期：2020-06-02 00:00:00

abstract：:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...

journal_title：Nature communications

authors： Cao H,Chén OY,Chung Y,Forsyth JK,McEwen SC,Gee DG,Bearden CE,Addington J,Goodyear B,Cadenhead KS,Mirzakhanian H,Cornblatt BA,Carrión RE,Mathalon DH,McGlashan TH,Perkins DO,Belger A,Seidman LJ,Thermenos H,Tsuang MT,

更新日期：2018-09-21 00:00:00

abstract：:The insulator-to-metal transition continues to be a challenging subject, especially when electronic correlations are strong. In layered compounds, such as La2-xSrxNiO4 and La2-xBaxCuO4, the doped charge carriers can segregate into periodically spaced charge stripes separating narrow domains of antiferromagnetic order....

journal_title：Nature communications

authors： Anissimova S,Parshall D,Gu GD,Marty K,Lumsden MD,Chi S,Fernandez-Baca JA,Abernathy DL,Lamago D,Tranquada JM,Reznik D

更新日期：2014-03-17 00:00:00

abstract：:Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, which phosphorylates DH...

journal_title：Nature communications

authors： Hao JW,Wang J,Guo H,Zhao YY,Sun HH,Li YF,Lai XY,Zhao N,Wang X,Xie C,Hong L,Huang X,Wang HR,Li CB,Liang B,Chen S,Zhao TJ

更新日期：2020-09-21 00:00:00

abstract：:Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as well as the location and neighbouring sites of framework aluminium. Unfortunatel...

journal_title：Nature communications

authors： Perea DE,Arslan I,Liu J,Ristanović Z,Kovarik L,Arey BW,Lercher JA,Bare SR,Weckhuysen BM

更新日期：2015-07-02 00:00:00

abstract：:One of the important challenges in condensed matter science is to understand ultrafast, atomic-scale fluctuations that dictate dynamic processes in equilibrium and non-equilibrium materials. Here, we report an important step towards reaching that goal by using a state-of-the-art perfect crystal based split-and-delay s...

journal_title：Nature communications

authors： Roseker W,Hruszkewycz SO,Lehmkühler F,Walther M,Schulte-Schrepping H,Lee S,Osaka T,Strüder L,Hartmann R,Sikorski M,Song S,Robert A,Fuoss PH,Sutton M,Stephenson GB,Grübel G

更新日期：2018-04-27 00:00:00

abstract：:Colloidal interactions in nematic liquid crystals can be described as interactions between elastic multipoles that depend on particle shape, topology, chirality, boundary conditions and induced topological defects. Here, we describe a nematic colloidal system consisting of mesostructures of gold capable of inducing el...

journal_title：Nature communications

authors： Yuan Y,Tasinkevych M,Smalyukh II

更新日期：2020-01-10 00:00:00

abstract：:Natural systems frequently exploit intricate multiscale and multiphasic structures to achieve functionalities beyond those of man-made systems. Although understanding the chemical make-up of these systems is essential, the passive and active mechanics within biological systems are crucial when considering the many nat...

journal_title：Nature communications

authors： Egan P,Sinko R,LeDuc PR,Keten S

更新日期：2015-07-06 00:00:00

abstract：:The importance of singlet oxygen (1O2) in the environmental and biomedical fields has motivated research for effective 1O2 production. Electrocatalytic processes hold great potential for highly-automated and scalable 1O2 synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalyti...

journal_title：Nature communications

authors： Zhao Y,Sun M,Wang X,Wang C,Lu D,Ma W,Kube SA,Ma J,Elimelech M

更新日期：2020-12-04 00:00:00

abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

journal_title：Nature communications

authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

更新日期：2011-02-15 00:00:00