Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Macreadie PI,Anton A,Raven JA,Beaumont N,Connolly RM,Friess DA,Kelleway JJ,Kennedy H,Kuwae T,Lavery PS,Lovelock CE,Smale DA,Apostolaki ET,Atwood TB,Baldock J,Bianchi TS,Chmura GL,Eyre BD,Fourqurean JW,Hall-Spencer Jdoi
10.1038/s41467-019-13126-0subject
Has Abstractpub_date
2019-11-08 00:00:00pages
5145issue
1issn
2041-1723pii
10.1038/s41467-019-13126-0journal_volume
10pub_type
已发布勘误abstract::Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12281-8
更新日期:2019-09-19 00:00:00
abstract::Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15472-w
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abstract::The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7320
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abstract::The yeast Rab5 homologue, Vps21p, is known to be involved both in the vacuolar protein sorting (VPS) pathway from the trans-Golgi network to the vacuole, and in the endocytic pathway from the plasma membrane to the vacuole. However, the intracellular location at which these two pathways converge remains unclear. In ad...
journal_title:Nature communications
pub_type: 杂志文章
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abstract::Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19009-z
更新日期:2020-10-16 00:00:00
abstract::Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on e...
journal_title:Nature communications
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doi:10.1038/s41467-020-19331-6
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abstract::Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...
journal_title:Nature communications
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doi:10.1038/ncomms15762
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abstract::Pools of carbon dioxide are found in natural geological accumulations and in engineered storage in saline aquifers. It has been thought that once this CO2 dissolves in the formation water, making it denser, convection streams will transport it efficiently to depth, but this may not be so. Here, we assess theoretically...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6743
更新日期:2014-12-11 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, whic...
journal_title:Nature communications
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doi:10.1038/s41467-019-10106-2
更新日期:2019-05-15 00:00:00
abstract::Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title:Nature communications
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doi:10.1038/s41467-018-03001-9
更新日期:2018-02-12 00:00:00
abstract::Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9502
更新日期:2015-10-07 00:00:00
abstract::In bulk superfluid 3He at zero magnetic field, two phases emerge with the B-phase stable everywhere except at high pressures and temperatures, where the A-phase is favoured. Aerogels with nanostructure smaller than the superfluid coherence length are the only means to introduce disorder into the superfluid. Here we us...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12975
更新日期:2016-09-27 00:00:00
abstract::Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription facto...
journal_title:Nature communications
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doi:10.1038/s41467-018-04719-2
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abstract::Deformation twins are three-dimensional domains, traditionally viewed as ellipsoids because of their two-dimensional lenticular sections. In this work, we performed statistical analysis of twin shapes viewing along three orthogonal directions: the 'dark side' (DS) view along the twin shear direction (η1), the twinning...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10573-7
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abstract::Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...
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pub_type: 杂志文章
doi:10.1038/ncomms3112
更新日期:2013-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11859-6
更新日期:2019-08-21 00:00:00
abstract::There is large interspecific variation in the magnitude of population fluctuations, even among closely related species. The factors generating this variation are not well understood, primarily because of the challenges of separating the relative impact of variation in population size from fluctuations in the environme...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12001
更新日期:2016-06-22 00:00:00
abstract::Covalent organic frameworks (COFs) have served as a family of porous crystalline molecules for various promising applications. However, controllable synthesis of COFs with uniform morphology is paramount yet still remains quite challenging. Herein, we report self-templated synthesis of uniform and unique hollow sphere...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18844-4
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abstract::A topological insulator is the state of quantum matter possessing gapless spin-locking surface states across the bulk band gap, which has created new opportunities from novel electronics to energy conversion. However, the large concentration of bulk residual carriers has been a major challenge for revealing the proper...
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doi:10.1038/ncomms1771
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abstract::Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show that deep learning algorithm enables automated acquisition of explainable features from diagnostic annotation-fr...
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abstract::The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...
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abstract::Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...
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doi:10.1038/s41467-019-12314-2
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abstract::When two-dimensional crystals are brought into close proximity, their interaction results in reconstruction of electronic spectrum and crystal structure. Such reconstruction strongly depends on the twist angle between the crystals, which has received growing attention due to interesting electronic and optical properti...
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doi:10.1038/s41467-020-20667-2
更新日期:2021-01-12 00:00:00
abstract::It is well known that a topologically protected gapless state appears at an interface between a topological insulator and an ordinary insulator; however, the physics of the interface between a topological insulator and a metal has largely been left unexplored. Here we report a novel phenomenon termed topological proxi...
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更新日期:2015-03-12 00:00:00
abstract::Runoff from the Greenland Ice Sheet (GrIS) is thought to enhance marine productivity by adding bioessential iron and silicic acid to coastal waters. However, experimental data suggest nitrate is the main summertime growth-limiting resource in regions affected by meltwater around Greenland. While meltwater contains low...
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abstract::The search for two-dimensional quantum spin liquids, exotic magnetic states remaining disordered down to zero temperature, has been a great challenge in frustrated magnetism over the last few decades. Recently, evidence for fractionalized excitations, called spinons, emerging from these states has been observed in kag...
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doi:10.1038/s41467-018-06212-2
更新日期:2018-09-17 00:00:00
abstract::Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...
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更新日期:2020-07-13 00:00:00
abstract::The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...
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abstract::Plants can produce organs throughout their entire life from pluripotent stem cells located at their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of Arabidopsis thaliana switches fate and starts producing flowers instead of leaves. Correct timing of flowering in part determines reprod...
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abstract::Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role. Here we show that monocyte-mediated gene delivery of IFNα inhibits l...
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更新日期:2018-07-24 00:00:00