Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.

abstract：:Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation. HJURP is the CENP-A chaperone, which associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. How these proteins interact to p...

journal_title：Nature communications

authors： Pan D,Walstein K,Take A,Bier D,Kaiser N,Musacchio A

更新日期：2019-09-06 00:00:00

abstract：:Rabies is a viral zoonosis transmitted by vampire bats across Latin America. Substantial public health and agricultural burdens remain, despite decades of bats culls and livestock vaccinations. Virally vectored vaccines that spread autonomously through bat populations are a theoretically appealing solution to managing...

journal_title：Nature communications

authors： Griffiths ME,Bergner LM,Broos A,Meza DK,Filipe ADS,Davison A,Tello C,Becker DJ,Streicker DG

更新日期：2020-11-23 00:00:00

abstract：:Expansion of Hevea brasiliensis rubber plantations is a resurgent driver of deforestation, carbon emissions, and biodiversity loss in Southeast Asia. Southeast Asian rubber extent is massive, equivalent to 67% of oil palm, with rapid further expansion predicted. Results-based carbon finance could dis-incentivise fores...

journal_title：Nature communications

authors： Warren-Thomas EM,Edwards DP,Bebber DP,Chhang P,Diment AN,Evans TD,Lambrick FH,Maxwell JF,Nut M,O'Kelly HJ,Theilade I,Dolman PM

更新日期：2018-03-02 00:00:00

abstract：:Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. ...

journal_title：Nature communications

authors： Liu W,Li Y,Shaw KS,Learn GH,Plenderleith LJ,Malenke JA,Sundararaman SA,Ramirez MA,Crystal PA,Smith AG,Bibollet-Ruche F,Ayouba A,Locatelli S,Esteban A,Mouacha F,Guichet E,Butel C,Ahuka-Mundeke S,Inogwabini BI,Ndjango

更新日期：2014-01-01 00:00:00

abstract：:Achieving control over the directionality of active colloids is essential for their use in practical applications such as cargo carriers in microfluidic devices. So far, guidance of spherical Janus colloids was mainly realized using specially engineered magnetic multilayer coatings combined with external magnetic fiel...

journal_title：Nature communications

authors： Simmchen J,Katuri J,Uspal WE,Popescu MN,Tasinkevych M,Sánchez S

更新日期：2016-02-09 00:00:00

abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

journal_title：Nature communications

authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

更新日期：2017-02-06 00:00:00

abstract：:Because of the potential impact on agriculture and other key human activities, efforts have been dedicated to the local control of precipitation. The most common approach consists of dispersing small particles of dry ice, silver iodide, or other salts in the atmosphere. Here we show, using field experiments conducted ...

journal_title：Nature communications

authors： Henin S,Petit Y,Rohwetter P,Stelmaszczyk K,Hao ZQ,Nakaema WM,Vogel A,Pohl T,Schneider F,Kasparian J,Weber K,Wöste L,Wolf JP

更新日期：2011-08-30 00:00:00

abstract：:In LaAlO(3)/SrTiO(3) heterointerfaces, charge carriers migrate from the LaAlO(3) to the interface in an electronic reconstruction. Magnetism has been observed in LaAlO(3)/SrTiO(3), but its relationship to the interface conductivity is unknown. Here we show that reconstruction is necessary, but not sufficient, for the ...

journal_title：Nature communications

authors： Kalisky B,Bert JA,Klopfer BB,Bell C,Sato HK,Hosoda M,Hikita Y,Hwang HY,Moler KA

更新日期：2012-06-26 00:00:00

abstract：:Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the ti...

journal_title：Nature communications

authors： Sengupta S,Tang SY,Devine JC,Anderson ST,Nayak S,Zhang SL,Valenzuela A,Fisher DG,Grant GR,López CB,FitzGerald GA

更新日期：2019-09-11 00:00:00

abstract：:Recent research has explored the spatiotemporal modulation of permittivity to break Lorentz reciprocity in a manner compatible with integrated-circuit fabrication. However, permittivity modulation is inherently weak and accompanied by loss due to carrier injection, particularly at higher frequencies, resulting in larg...

journal_title：Nature communications

authors： Dinc T,Tymchenko M,Nagulu A,Sounas D,Alu A,Krishnaswamy H

更新日期：2017-10-06 00:00:00

abstract：:The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH gene. Although LSH belongs to a family of chromatin remodeling proteins, it remains unknown how LSH mediates its function on chromatin in vivo. Here, we use ch...

journal_title：Nature communications

authors： Ni K,Ren J,Xu X,He Y,Finney R,Braun SMG,Hathaway NA,Crabtree GR,Muegge K

更新日期：2020-11-06 00:00:00

abstract：:Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDE...

journal_title：Nature communications

authors： Deng Z,Mu J,Tseng M,Wattenberg B,Zhuang X,Egilmez NK,Wang Q,Zhang L,Norris J,Guo H,Yan J,Haribabu B,Miller D,Zhang HG

更新日期：2015-04-24 00:00:00

abstract：:The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that...

journal_title：Nature communications

authors： Ogrodnik M,Miwa S,Tchkonia T,Tiniakos D,Wilson CL,Lahat A,Day CP,Burt A,Palmer A,Anstee QM,Grellscheid SN,Hoeijmakers JHJ,Barnhoorn S,Mann DA,Bird TG,Vermeij WP,Kirkland JL,Passos JF,von Zglinicki T,Jurk D

更新日期：2017-06-13 00:00:00

abstract：:Replacing sluggish oxygen evolution reaction (OER) with hydrazine oxidation reaction (HzOR) to produce hydrogen has been considered as a more energy-efficient strategy than water splitting. However, the relatively high cell voltage in two-electrode system and the required external electric power hinder its scalable ap...

journal_title：Nature communications

authors： Liu Y,Zhang J,Li Y,Qian Q,Li Z,Zhu Y,Zhang G

更新日期：2020-04-15 00:00:00

abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

journal_title：Nature communications

authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

更新日期：2012-05-01 00:00:00

abstract：:Complex oxide heterointerfaces and van der Waals heterostructures present two versatile but intrinsically different platforms for exploring emergent quantum phenomena and designing new functionalities. The rich opportunity offered by the synergy between these two classes of materials, however, is yet to be charted. He...

journal_title：Nature communications

authors： Li D,Huang X,Xiao Z,Chen H,Zhang L,Hao Y,Song J,Shao DF,Tsymbal EY,Lu Y,Hong X

更新日期：2020-03-17 00:00:00

abstract：:In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and the production of s...

journal_title：Nature communications

authors： Pérez-García A,Marina-Zárate E,Álvarez-Prado ÁF,Ligos JM,Galjart N,Ramiro AR

更新日期：2017-07-05 00:00:00

abstract：:Postsynaptic density (PSD) proteins have been implicated in the pathophysiology of neurodevelopmental and psychiatric disorders. Here, we present detailed clinical and genetic data for 20 patients with likely gene-disrupting mutations in TANC2-whose protein product interacts with multiple PSD proteins. Pediatric patie...

journal_title：Nature communications

authors： Guo H,Bettella E,Marcogliese PC,Zhao R,Andrews JC,Nowakowski TJ,Gillentine MA,Hoekzema K,Wang T,Wu H,Jangam S,Liu C,Ni H,Willemsen MH,van Bon BW,Rinne T,Stevens SJC,Kleefstra T,Brunner HG,Yntema HG,Long M,Zhao W

更新日期：2019-10-15 00:00:00

abstract：:Ubiquitous satellite communications are in a leading position for bridging the digital divide. Fulfilling such a mission will require satellite services on par with fibre services, both in bandwidth and cost. Achieving such a performance requires a new generation of communications payloads powered by large-scale proce...

journal_title：Nature communications

authors： Duarte VC,Prata JG,Ribeiro CF,Nogueira RN,Winzer G,Zimmermann L,Walker R,Clements S,Filipowicz M,Napierała M,Nasiłowski T,Crabb J,Kechagias M,Stampoulidis L,Anzalchi J,Drummond MV

更新日期：2019-04-30 00:00:00

abstract：:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...

journal_title：Nature communications

authors： Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

更新日期：2019-04-12 00:00:00

abstract：:Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of...

journal_title：Nature communications

authors： Zhang J,Cheng X,Ding MD

更新日期：2012-03-20 00:00:00

abstract：:Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole's distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely determine where distal appendage proteins localize in relation to the ...

journal_title：Nature communications

authors： Bowler M,Kong D,Sun S,Nanjundappa R,Evans L,Farmer V,Holland A,Mahjoub MR,Sui H,Loncarek J

更新日期：2019-03-01 00:00:00

abstract：:New microbial genomes are constantly being sequenced, and it is crucial to accurately determine their taxonomic identities and evolutionary relationships. Here we report PhyloPhlAn, a new method to assign microbial phylogeny and putative taxonomy using >400 proteins optimized from among 3,737 genomes. This method meas...

journal_title：Nature communications

authors： Segata N,Börnigen D,Morgan XC,Huttenhower C

更新日期：2013-01-01 00:00:00

abstract：:Emerging evidence has revealed that Nestin not only serves as a biomarker for multipotent stem cells, but also regulates cell proliferation and invasion in various tumors. However, the mechanistic contributions of Nestin to cancer pathogenesis are still unknown. In the present study, previously thought to reside exclu...

journal_title：Nature communications

authors： Zhang Y,Wang J,Huang W,Cai J,Ba J,Wang Y,Ke Q,Huang Y,Liu X,Qiu Y,Lu Q,Sui X,Shi Y,Wang T,Shen H,Guan Y,Zhou Y,Chen Y,Wang M,Xiang AP

更新日期：2018-09-06 00:00:00

abstract：:The search for two-dimensional quantum spin liquids, exotic magnetic states remaining disordered down to zero temperature, has been a great challenge in frustrated magnetism over the last few decades. Recently, evidence for fractionalized excitations, called spinons, emerging from these states has been observed in kag...

journal_title：Nature communications

authors： Lhotel E,Petit S,Ciomaga Hatnean M,Ollivier J,Mutka H,Ressouche E,Lees MR,Balakrishnan G

更新日期：2018-09-17 00:00:00

abstract：:Capturing and controlling plasmons at buried interfaces with nanometre and femtosecond resolution has yet to be achieved and is critical for next generation plasmonic devices. Here we use light to excite plasmonic interference patterns at a buried metal-dielectric interface in a nanostructured thin film. Plasmons are ...

journal_title：Nature communications

authors： Lummen TTA,Lamb RJ,Berruto G,LaGrange T,Dal Negro L,García de Abajo FJ,McGrouther D,Barwick B,Carbone F

更新日期：2016-10-11 00:00:00

abstract：:Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher the mechanism of action. We found that miR-96/...

journal_title：Nature communications

authors： Gilam A,Conde J,Weissglas-Volkov D,Oliva N,Friedman E,Artzi N,Shomron N

更新日期：2016-09-19 00:00:00

abstract：:The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor ...

journal_title：Nature communications

authors： Feierabend M,Berghäuser G,Knorr A,Malic E

更新日期：2017-03-15 00:00:00

abstract：:Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 3...

journal_title：Nature communications

authors： Jean P,Anttonen T,Michanski S,de Diego AMG,Steyer AM,Neef A,Oestreicher D,Kroll J,Nardis C,Pangršič T,Möbius W,Ashmore J,Wichmann C,Moser T

更新日期：2020-06-25 00:00:00

abstract：:The description of ultrafast nonadiabatic chemical dynamics during molecular photo-transformations remains challenging because electronic and nuclear configurations impact each other and cannot be treated independently. Here we gain experimental insights, beyond the Born-Oppenheimer approximation, into the light-induc...

journal_title：Nature communications

authors： Lemke HT,Kjær KS,Hartsock R,van Driel TB,Chollet M,Glownia JM,Song S,Zhu D,Pace E,Matar SF,Nielsen MM,Benfatto M,Gaffney KJ,Collet E,Cammarata M

更新日期：2017-05-24 00:00:00