Abstract:
:Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the timing of influenza infection is not well understood. Here we demonstrate that endogenous rhythms affect survival in influenza infection. Circadian control of influenza infection is mediated by enhanced inflammation as proven by increased cellularity in bronchoalveolar lavage (BAL), pulmonary transcriptomic profile and histology and is not attributable to viral burden. Better survival is associated with a time dependent preponderance of NK and NKT cells and lower proportion of inflammatory monocytes in the lung. Further, using a series of genetic mouse mutants, we elucidate cellular mechanisms underlying circadian gating of influenza infection.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sengupta S,Tang SY,Devine JC,Anderson ST,Nayak S,Zhang SL,Valenzuela A,Fisher DG,Grant GR,López CB,FitzGerald GAdoi
10.1038/s41467-019-11400-9subject
Has Abstractpub_date
2019-09-11 00:00:00pages
4107issue
1issn
2041-1723pii
10.1038/s41467-019-11400-9journal_volume
10pub_type
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