Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination.

Abstract:

:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP coordination, thus producing (Mg2+-BP)-Au dimer (MgBNP). Ethylenediaminetetraacetic acid-based Mg2+ chelation facilitates the dissolution of Mg2+-BP NP, thus enabling the reversion of the MgBNP to the BNP. This convertible nanoassembly incorporating cell-adhesive Mg2+ moieties directs reversible attachment and detachment of macrophages by BP and EDTA, without physical scraping or trypsin that could damage cells. The swift formation of RGD ligand- and Mg2+-bifunctional RGD-Mg2+-BP NP that yields (RGD-Mg2+-BP)-Au dimer (RGDBNP) further stimulates the adhesion and pro-regenerative M2-type polarization of macrophages, both in vitro and in vivo, including rho-associated protein kinase. This swift and non-toxic dimer formation can include diverse bio-functional moieties to regulate host responses to implants.

journal_name

Nat Commun

journal_title

Nature communications

authors

Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

doi

10.1038/s41467-019-09733-6

subject

Has Abstract

pub_date

2019-04-12 00:00:00

pages

1696

issue

1

issn

2041-1723

pii

10.1038/s41467-019-09733-6

journal_volume

10

pub_type

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