Abstract：
:Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4(+) T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes(+) CD4(+) T cells.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Raveney BJ,Oki S,Hohjoh H,Nakamura M,Sato W,Murata M,Yamamura Tdoi
10.1038/ncomms9437subject
Has Abstractpub_date
2015-10-05 00:00:00pages
8437issn
2041-1723pii
ncomms9437journal_volume
6pub_type
杂志文章abstract：:An industrial process for the selective activation of methane under mild conditions would be highly valuable for controlling emissions to the environment and for utilizing vast new sources of natural gas. The only selective catalysts for methane activation and conversion to methanol under mild conditions are methane m...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11900
更新日期：2016-06-15 00:00:00
abstract：:Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15638-6
更新日期：2020-04-21 00:00:00
abstract：:To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the carrier that catalyzes ATP uptake into the ER was unknown. Here, we report that our screen of gene expression datasets for member(s) of the fam...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06003-9
更新日期：2018-08-28 00:00:00
abstract：:Photocatalysis has not found widespread industrial adoption, in spite of decades of active research, because the challenges associated with catalyst illumination and turnover outweigh the touted advantages of replacing heat with light. A demonstration that light can control product selectivity in complex chemical reac...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14542
更新日期：2017-02-23 00:00:00
abstract：:The Mott metal-insulator transition-a manifestation of Coulomb interactions among electrons-is known as a discontinuous transition. Recent theoretical studies, however, suggest that the transition is continuous if the Mott insulator carries a spin liquid with a spinon Fermi surface. Here, we demonstrate the case of a ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02679-7
更新日期：2018-01-22 00:00:00
abstract：:The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19537-8
更新日期：2020-11-10 00:00:00
abstract：:Genomic evidence is increasingly underpinning that hybridization between taxa is commonplace, challenging our views on the mechanisms that maintain their boundaries. Here, we focus on seven catadromous eel species (genus Anguilla) and use genome-wide sequence data from more than 450 individuals sampled across the trop...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15099-x
更新日期：2020-03-18 00:00:00
abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1071
更新日期：2010-09-07 00:00:00
abstract：:Many biological processes involve large-scale changes in membrane shape. Computer simulations of these processes are challenging since they occur across a wide range of spatiotemporal scales that cannot be investigated in full by any single current simulation technique. A potential solution is to combine different lev...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16094-y
更新日期：2020-05-08 00:00:00
abstract：:Serial X-ray crystallography allows macromolecular structure determination at both X-ray free electron lasers (XFELs) and, more recently, synchrotron sources. The time resolution for serial synchrotron crystallography experiments has been limited to millisecond timescales with monochromatic beams. The polychromatic, "...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01417-3
更新日期：2017-11-03 00:00:00
abstract：:Rabi oscillations describe the process whereby electromagnetic radiation interacts coherently with spin states in a non-equilibrium interaction. To date, Rabi oscillations have not been studied in one of the most common spin ensembles in nature: spins in ferromagnets. Here, using a combination of femtosecond laser pul...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms16004
更新日期：2017-06-28 00:00:00
abstract：:Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain poorly understood. Here, we report the characterizatio...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7030
更新日期：2015-01-16 00:00:00
abstract：:Anthropogenic methane emissions from China are likely greater than in any other country in the world. The largest fraction of China's anthropogenic emissions is attributable to coal mining, but these emissions may be changing; China enacted a suite of regulations for coal mine methane (CMM) drainage and utilization th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07891-7
更新日期：2019-01-29 00:00:00
abstract：:Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Baloxavir blocks virus replication more rapidly ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16585-y
更新日期：2020-06-02 00:00:00
abstract：:Metal particles supported on oxide surfaces are used as catalysts for a wide variety of processes in the chemical and energy conversion industries. For catalytic applications, metal particles are generally formed on an oxide support by physical or chemical deposition, or less commonly by exsolution from it. Although f...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9120
更新日期：2015-09-11 00:00:00
abstract：:Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to pat...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07598-9
更新日期：2018-12-06 00:00:00
abstract：:Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role. Here we show that monocyte-mediated gene delivery of IFNα inhibits l...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05315-0
更新日期：2018-07-24 00:00:00
abstract：:The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4548
更新日期：2014-03-27 00:00:00
abstract：:Van Allen radiation belts are typically two zones of energetic particles encircling the Earth separated by the slot region. How the outer radiation belt electrons are accelerated to relativistic energies remains an unanswered question. Recent studies have presented compelling evidence for the local acceleration by ver...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10096
更新日期：2015-12-22 00:00:00
abstract：:Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11174
更新日期：2016-03-31 00:00:00
abstract：:Wild boar (Sus scrofa) drastically colonized mainland Eurasia and North Africa, most likely from East Asia during the Plio-Pleistocene (2-1Mya). In recent studies, based on genome-wide information, it was hypothesized that wild boar did not replace the species it encountered, but instead exchanged genetic materials wi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10017-2
更新日期：2019-04-30 00:00:00
abstract：:Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08060-6
更新日期：2019-01-14 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-020-15018-0
更新日期：2020-02-25 00:00:00
abstract：:Enantioenriched 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their efficient synthesis directly from chemical feedstock is highly sought after. Here, we show an enantioselective cross-hydroalkenylation of cyclic 1,3-diene and hetero-substituted terminal olefin by using a chiral [NHC-Ni(a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16139-2
更新日期：2020-05-08 00:00:00
abstract：:Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for NALP7 protein stabil...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15203
更新日期：2017-05-11 00:00:00
abstract：:The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this class. Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1409
更新日期：2011-07-19 00:00:00
abstract：:Incorporating oxophilic metals into noble metal-based catalysts represents an emerging strategy to improve the catalytic performance of electrocatalysts in fuel cells. However, effects of the distance between the noble metal and oxophilic metal active sites on the catalytic performance have rarely been investigated. H...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14136
更新日期：2017-01-10 00:00:00
abstract：:In the original version of this Article, the sixth sentence of the abstract incorrectly read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change.', and should have read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-06482-w
更新日期：2018-09-25 00:00:00
abstract：:Osmoregulation is important for plant growth, development and response to environmental changes. SNF1-related protein kinase 2s (SnRK2s) are quickly activated by osmotic stress and are central components in osmotic stress and abscisic acid (ABA) signaling pathways; however, the upstream components required for SnRK2 a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14477-9
更新日期：2020-01-30 00:00:00
abstract：:The original version of this Article omitted references to previous experimental reports on solid hydrogen that are relevant for a full understanding of the context of the previous work. The added references are: 47. Akahama, Y. et al. Evidence from x-ray diffraction of orientational ordering in phase III of solid hyd...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-10187-z
更新日期：2019-05-03 00:00:00
