Publisher Correction: Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.


:In the original version of this Article, the sixth sentence of the abstract incorrectly read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change.', and should have read 'Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26Met HCC model undergo the same change in a large proportion of HCC patients.'. This has been corrected in both the PDF and HTML versions of the Article.


Nat Commun


Nature communications


Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F




Has Abstract


2018-09-25 00:00:00












  • Asymmetric construction of tetrahedral chiral zinc with high configurational stability and catalytic activity.

    abstract::Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Endo K,Liu Y,Ube H,Nagata K,Shionoya M

    更新日期:2020-12-09 00:00:00

  • Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

    abstract::Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDE...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Deng Z,Mu J,Tseng M,Wattenberg B,Zhuang X,Egilmez NK,Wang Q,Zhang L,Norris J,Guo H,Yan J,Haribabu B,Miller D,Zhang HG

    更新日期:2015-04-24 00:00:00

  • Initial effective stress controls the nature of earthquakes.

    abstract::Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still debated. Here, we first highlight how the different types of f...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Passelègue FX,Almakari M,Dublanchet P,Barras F,Fortin J,Violay M

    更新日期:2020-10-12 00:00:00

  • Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase.

    abstract::Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Jurado AR,Huang CS,Zhang X,Zhou ZH,Tong L

    更新日期:2015-11-23 00:00:00

  • Power laws in pressure-induced structural change of glasses.

    abstract::Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhang H,Qiao K,Han Y

    更新日期:2020-04-24 00:00:00

  • Benchmarking monolayer MoS2 and WS2 field-effect transistors.

    abstract::Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

    更新日期:2021-01-29 00:00:00

  • Implications of improved representations of plant respiration in a changing climate.

    abstract::Land-atmosphere exchanges influence atmospheric CO2. Emphasis has been on describing photosynthetic CO2 uptake, but less on respiration losses. New global datasets describe upper canopy dark respiration (R d) and temperature dependencies. This allows characterisation of baseline R d, instantaneous temperature response...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Huntingford C,Atkin OK,Martinez-de la Torre A,Mercado LM,Heskel MA,Harper AB,Bloomfield KJ,O'Sullivan OS,Reich PB,Wythers KR,Butler EE,Chen M,Griffin KL,Meir P,Tjoelker MG,Turnbull MH,Sitch S,Wiltshire A,Malhi Y

    更新日期:2017-11-17 00:00:00

  • Global perturbation of organic carbon cycling by river damming.

    abstract::The damming of rivers represents one of the most far-reaching human modifications of the flows of water and associated matter from land to sea. Dam reservoirs are hotspots of sediment accumulation, primary productivity (P) and carbon mineralization (R) along the river continuum. Here we show that for the period 1970-2...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Maavara T,Lauerwald R,Regnier P,Van Cappellen P

    更新日期:2017-05-17 00:00:00

  • Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer.

    abstract::The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

    更新日期:2018-07-24 00:00:00

  • Author Correction: REST regulates the cell cycle for cardiac development and regeneration.

    abstract::The original version of this Article contained an error in the spelling of the author Jianyun Yan, which was incorrectly given as Jiangyun Yan. This has now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误


    authors: Zhang D,Wang Y,Lu P,Wang P,Yuan X,Yan J,Cai C,Chang CP,Zheng D,Wu B,Zhou B

    更新日期:2018-01-12 00:00:00

  • Lysine methylation of VCP by a member of a novel human protein methyltransferase family.

    abstract::Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kernstock S,Davydova E,Jakobsson M,Moen A,Pettersen S,Mælandsmo GM,Egge-Jacobsen W,Falnes PØ

    更新日期:2012-01-01 00:00:00

  • UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution.

    abstract::The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein's amino acids ('intra-gene epistasis'). Our limited understanding of such epistasis hinders the correct prediction of the funct...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zurek PJ,Knyphausen P,Neufeld K,Pushpanath A,Hollfelder F

    更新日期:2020-11-26 00:00:00

  • CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation.

    abstract::In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and the production of s...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Pérez-García A,Marina-Zárate E,Álvarez-Prado ÁF,Ligos JM,Galjart N,Ramiro AR

    更新日期:2017-07-05 00:00:00

  • Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing.

    abstract::Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization f...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Mariani S,Robbiano V,Strambini LM,Debrassi A,Egri G,Dähne L,Barillaro G

    更新日期:2018-12-10 00:00:00

  • Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation.

    abstract::Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. However, little is known about genomic changes during natural colonisation. Here, we use whole-genome sequencing to investigate within-host microevolu...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Chaguza C,Senghore M,Bojang E,Gladstone RA,Lo SW,Tientcheu PE,Bancroft RE,Worwui A,Foster-Nyarko E,Ceesay F,Okoi C,McGee L,Klugman KP,Breiman RF,Barer MR,Adegbola RA,Antonio M,Bentley SD,Kwambana-Adams BA

    更新日期:2020-07-10 00:00:00

  • Pushing the boundaries of optoacoustic microscopy by total impulse response characterization.

    abstract::Optical microscopy improves in resolution and signal-to-noise ratio by correcting for the system's point spread function; a measure of how a point source is resolved, typically determined by imaging nanospheres. Optical-resolution optoacoustic (photoacoustic) microscopy could be similarly corrected, especially to acco...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Seeger M,Soliman D,Aguirre J,Diot G,Wierzbowski J,Ntziachristos V

    更新日期:2020-06-09 00:00:00

  • Accurate prediction of X-ray pulse properties from a free-electron laser using machine learning.

    abstract::Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and te...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Sanchez-Gonzalez A,Micaelli P,Olivier C,Barillot TR,Ilchen M,Lutman AA,Marinelli A,Maxwell T,Achner A,Agåker M,Berrah N,Bostedt C,Bozek JD,Buck J,Bucksbaum PH,Montero SC,Cooper B,Cryan JP,Dong M,Feifel R,Frasinski

    更新日期:2017-06-05 00:00:00

  • Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method.

    abstract::Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) able to correlate the levels of multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy add...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Lin JR,Fallahi-Sichani M,Sorger PK

    更新日期:2015-09-24 00:00:00

  • Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.

    abstract::Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we determin...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Xiang W,Shi R,Kang X,Zhang X,Chen P,Zhang L,Hou A,Wang R,Zhao Y,Zhao K,Liu Y,Ma Y,Luo H,Shang S,Zhang J,He F,Yu S,Gan L,Shi C,Li Y,Yang W,Liang H,Miao H

    更新日期:2018-07-03 00:00:00

  • Single-digit-micrometer thickness wood speaker.

    abstract::Thin films of several microns in thickness are ubiquitously used in packaging, electronics, and acoustic sensors. Here we demonstrate that natural wood can be directly converted into an ultrathin film with a record-small thickness of less than 10 μm through partial delignification followed by densification. Benefiting...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Gan W,Chen C,Kim HT,Lin Z,Dai J,Dong Z,Zhou Z,Ping W,He S,Xiao S,Yu M,Hu L

    更新日期:2019-11-08 00:00:00

  • High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics.

    abstract::The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Schmid B,Shah G,Scherf N,Weber M,Thierbach K,Campos CP,Roeder I,Aanstad P,Huisken J

    更新日期:2013-01-01 00:00:00

  • Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.

    abstract::Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macrophage-driven prote...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Boytard L,Hadi T,Silvestro M,Qu H,Kumpfbeck A,Sleiman R,Fils KH,Alebrahim D,Boccalatte F,Kugler M,Corsica A,Gelb BE,Jacobowitz G,Miller G,Bellini C,Oakes J,Silvestre JS,Zangi L,Ramkhelawon B

    更新日期:2020-08-27 00:00:00

  • Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

    abstract::The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discoverin...

    journal_title:Nature communications

    pub_type: 杂志文章,meta分析


    authors: Ntalla I,Weng LC,Cartwright JH,Hall AW,Sveinbjornsson G,Tucker NR,Choi SH,Chaffin MD,Roselli C,Barnes MR,Mifsud B,Warren HR,Hayward C,Marten J,Cranley JJ,Concas MP,Gasparini P,Boutin T,Kolcic I,Polasek O,Rudan I,

    更新日期:2020-05-21 00:00:00

  • Nutrients cause grassland biomass to outpace herbivory.

    abstract::Human activities are transforming grassland biomass via changing climate, elemental nutrients, and herbivory. Theory predicts that food-limited herbivores will consume any additional biomass stimulated by nutrient inputs ('consumer-controlled'). Alternatively, nutrient supply is predicted to increase biomass where her...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Borer ET,Harpole WS,Adler PB,Arnillas CA,Bugalho MN,Cadotte MW,Caldeira MC,Campana S,Dickman CR,Dickson TL,Donohue I,Eskelinen A,Firn JL,Graff P,Gruner DS,Heckman RW,Koltz AM,Komatsu KJ,Lannes LS,MacDougall AS,Mar

    更新日期:2020-11-27 00:00:00

  • Licensing MLH1 sites for crossover during meiosis.

    abstract::During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues. Here we report that--in wheat-rye hybrids where homologue...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Martín AC,Shaw P,Phillips D,Reader S,Moore G

    更新日期:2014-08-06 00:00:00

  • Ligands with 1,10-phenanthroline scaffold for highly regioselective iron-catalyzed alkene hydrosilylation.

    abstract::Transition-metal-catalyzed alkene hydrosilylation is one of the most important homogeneous catalytic reactions, and the development of methods that use base metals, especially iron, as catalysts for this transformation is a growing area of research. However, the limited number of ligand scaffolds applicable for base-m...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Hu MY,He Q,Fan SJ,Wang ZC,Liu LY,Mu YJ,Peng Q,Zhu SF

    更新日期:2018-01-15 00:00:00

  • Universal structure of transmission eigenchannels inside opaque media.

    abstract::As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Davy M,Shi Z,Park J,Tian C,Genack AZ

    更新日期:2015-04-20 00:00:00

  • Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.

    abstract::Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the structural origin f...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ryckbosch SM,Wender PA,Pande VS

    更新日期:2017-02-23 00:00:00

  • Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders.

    abstract::Cystic fibrosis (CF) is a genetic disorder caused by defective CF Transmembrane Conductance Regulator (CFTR) function. Insulin producing pancreatic islets are located in close proximity to the pancreatic duct and there is a possibility of impaired cell-cell signaling between pancreatic ductal epithelial cells (PDECs) ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Shik Mun K,Arora K,Huang Y,Yang F,Yarlagadda S,Ramananda Y,Abu-El-Haija M,Palermo JJ,Appakalai BN,Nathan JD,Naren AP

    更新日期:2019-07-16 00:00:00

  • Impact of fat mass and distribution on lipid turnover in human adipose tissue.

    abstract::Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride a...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Spalding KL,Bernard S,Näslund E,Salehpour M,Possnert G,Appelsved L,Fu KY,Alkass K,Druid H,Thorell A,Rydén M,Arner P

    更新日期:2017-05-23 00:00:00