Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Communjournal_title
Nature communicationsauthors
López-Barneo J,Simon MCdoi
10.1038/s41467-020-15018-0subject
Has Abstractpub_date
2020-02-25 00:00:00pages
1140issue
1issn
2041-1723pii
10.1038/s41467-020-15018-0journal_volume
11pub_type
已发布勘误abstract::Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4075
更新日期:2014-01-01 00:00:00
abstract::In nature, plant tendrils can produce two fundamental motion modes, bending and chiral twisting (helical curling) distortions, under the stimuli of sunlight, humidity, wetting or other atmospheric conditions. To date, many artificial plant-like mechanical machines have been developed. Although some previously reported...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13981
更新日期:2016-12-22 00:00:00
abstract::Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Götting...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07765-y
更新日期:2018-12-11 00:00:00
abstract::High harmonics generated by counter-rotating laser fields at the fundamental and second harmonic frequencies have raised important interest as a table-top source of circularly polarized ultrashort extreme-ultraviolet light. However, this emission has not yet been fully characterized: in particular it was assumed to be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07151-8
更新日期:2018-11-09 00:00:00
abstract::Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12748-8
更新日期:2019-10-25 00:00:00
abstract::Liquid-liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12402-3
更新日期:2019-10-04 00:00:00
abstract::Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this process are associated with several human diseas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04122-x
更新日期:2018-04-30 00:00:00
abstract::Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08038-4
更新日期:2019-01-10 00:00:00
abstract::Establishing processing-structure-property relationships for monolayer materials is crucial for a range of applications spanning optics, catalysis, electronics and energy. Presently, for molybdenum disulfide, a promising catalyst for artificial photosynthesis, considerable debate surrounds the structure/property relat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9311
更新日期:2015-10-07 00:00:00
abstract::We report color-selective photodetection from intermediate, monolayered, quantum dots buried in between amorphous-oxide semiconductors. The proposed active channel in phototransistors is a hybrid configuration of oxide-quantum dot-oxide layers, where the gate-tunable electrical property of silicon-doped, indium-zinc-o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00893-x
更新日期:2017-10-10 00:00:00
abstract::Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06090-8
更新日期:2018-09-07 00:00:00
abstract::Reliable quantum information processing in the face of errors is a major fundamental and technological challenge. Quantum error correction protects quantum states by encoding a logical quantum bit (qubit) in multiple physical qubits. To be compatible with universal fault-tolerant computations, it is essential that sta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11526
更新日期:2016-05-05 00:00:00
abstract::Decision making in dynamic environments requires discounting old evidence that may no longer inform the current state of the world. Previous work found that humans discount old evidence in a dynamic environment, but do not discount at the optimal rate. Here we investigated whether rats can optimally discount evidence ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06561-y
更新日期:2018-10-15 00:00:00
abstract::Materials hosting magnetic skyrmions at room temperature could enable compact and energetically-efficient storage such as racetrack memories, where information is coded by the presence/absence of skyrmions forming a moving chain through the device. The skyrmion Hall effect leading to their annihilation at the racetrac...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20025-2
更新日期:2020-12-11 00:00:00
abstract::Animal propulsors such as wings and fins bend during motion and these bending patterns are believed to contribute to the high efficiency of animal movements compared with those of man-made designs. However, efforts to implement flexible designs have been met with contradictory performance results. Consequently, there ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4293
更新日期:2014-01-01 00:00:00
abstract::A non-syngas direct steam reforming route is investigated for the conversion of methanol to hydrogen and carbon dioxide over a CuZnGaO(x) catalyst at 150-200 °C. This route is in marked contrast with the conventional complex route involving steam reformation to syngas (CO/H2) at high temperature, followed by water gas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2242
更新日期:2012-01-01 00:00:00
abstract::Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06381-0
更新日期:2018-10-08 00:00:00
abstract::Theory predicts a trade-off between investments in precopulatory (ornaments and armaments) and postcopulatory (testes and ejaculates) sexual traits due to the costs associated with their growth and maintenance within the finite energy resources available. Empirical studies, however, have revealed considerable inconsis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4184
更新日期:2014-01-01 00:00:00
abstract::Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Ear...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5914
更新日期:2014-09-11 00:00:00
abstract::Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7809
更新日期:2015-04-10 00:00:00
abstract::In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which adeno-associated virus...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14716
更新日期:2017-03-14 00:00:00
abstract::Transition metal oxides host a wealth of exotic phenomena ranging from charge, orbital and magnetic order to nontrivial topological phases and superconductivity. In order to translate these unique materials properties into device functionalities these materials must be doped; however, the nature of carriers and their ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15769
更新日期:2017-06-08 00:00:00
abstract::Density functional theory (DFT) is the standard formalism to study the electronic structure of matter at the atomic scale. In Kohn-Sham DFT simulations, the balance between accuracy and computational cost depends on the choice of exchange and correlation functional, which only exists in approximate form. Here, we prop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17265-7
更新日期:2020-07-14 00:00:00
abstract::MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 suggests it has additional interactions with chromatin. Here we demonstrate, by ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16907-0
更新日期:2020-06-19 00:00:00
abstract::Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00108-3
更新日期:2017-07-25 00:00:00
abstract::A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12762-w
更新日期:2019-10-18 00:00:00
abstract::Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2741
更新日期:2013-01-01 00:00:00
abstract::Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obes...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7495
更新日期:2015-03-11 00:00:00
abstract::Striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). GABAergic feedforward inhibition is known to control the integration of cortical information by striatal projection neurons (SPNs). ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05847-5
更新日期:2018-08-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11151-7
更新日期:2019-07-22 00:00:00