Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.

abstract：:Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) en...

journal_title：Nature communications

authors： Huynh N,Ou Q,Cox P,Lill R,King-Jones K

更新日期：2019-11-29 00:00:00

abstract：:Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory cell arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. H...

journal_title：Nature communications

authors： Ji Y,Zeigler DF,Lee DS,Choi H,Jen AK,Ko HC,Kim TW

更新日期：2013-01-01 00:00:00

abstract：:Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...

journal_title：Nature communications

authors： Yamamoto T,Doi M

更新日期：2014-06-17 00:00:00

abstract：:Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...

journal_title：Nature communications

authors： Yeung CT,Yim KH,Wong HY,Pal R,Lo WS,Yan SC,Yee-Man Wong M,Yufit D,Smiles DE,McCormick LJ,Teat SJ,Shuh DK,Wong WT,Law GL

更新日期：2017-10-24 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:Preterm infants exhibit different microbiome colonization patterns relative to full-term infants, and it is speculated that the hospital room environment may contribute to infant microbiome development. Here, we present a genome-resolved metagenomic study of microbial genotypes from the gastrointestinal tracts of infa...

journal_title：Nature communications

authors： Brooks B,Olm MR,Firek BA,Baker R,Thomas BC,Morowitz MJ,Banfield JF

更新日期：2017-11-27 00:00:00

abstract：:Acoustic communication is enabled by the evolution of specialised hearing and sound producing organs. In this study, we performed a large-scale macroevolutionary study to understand how both hearing and sound production evolved and affected diversification in the insect order Orthoptera, which includes many familiar s...

journal_title：Nature communications

authors： Song H,Béthoux O,Shin S,Donath A,Letsch H,Liu S,McKenna DD,Meng G,Misof B,Podsiadlowski L,Zhou X,Wipfler B,Simon S

更新日期：2020-10-02 00:00:00

abstract：:Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...

journal_title：Nature communications

authors： Väliranta M,Salonen JS,Heikkilä M,Amon L,Helmens K,Klimaschewski A,Kuhry P,Kultti S,Poska A,Shala S,Veski S,Birks HH

更新日期：2015-04-10 00:00:00

abstract：:Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism in eukaryotic cells. Although recent computational and structural studies have provided insights into RNA recognition by PPR proteins, their highly insoluble nature and inconsistencies between predicted and observed modes of RNA binding ...

journal_title：Nature communications

authors： Coquille S,Filipovska A,Chia T,Rajappa L,Lingford JP,Razif MF,Thore S,Rackham O

更新日期：2014-12-17 00:00:00

abstract：:Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome sequencing of four laryngeal carcinomas and their...

journal_title：Nature communications

authors： Fanjul-Fernández M,Quesada V,Cabanillas R,Cadiñanos J,Fontanil T,Obaya A,Ramsay AJ,Llorente JL,Astudillo A,Cal S,López-Otín C

更新日期：2013-01-01 00:00:00

abstract：:The originally published version of this Article contained an error in the spelling of the author Md. Saiful Islam, which was incorrectly given as Saiful Islam. This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wilkins SE,Islam MS,Gannon JM,Markolovic S,Hopkinson RJ,Ge W,Schofield CJ,Chowdhury R

更新日期：2018-04-23 00:00:00

abstract：:Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the telencephalon in vertebrate embryos. Ascidians, which belong to Tunicata, the sister group of vertebrates, develop a primitive placode-like structure at the anterior boundary of the neural plate, bu...

journal_title：Nature communications

authors： Liu B,Satou Y

更新日期：2019-10-29 00:00:00

abstract：:Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Baloxavir blocks virus replication more rapidly ...

journal_title：Nature communications

authors： Du Z,Nugent C,Galvani AP,Krug RM,Meyers LA

更新日期：2020-06-02 00:00:00

abstract：:Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25-3,500). We estab...

journal_title：Nature communications

authors： Das P,Malho JM,Rahimi K,Schacher FH,Wang B,Demco DE,Walther A

更新日期：2015-01-20 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is a model for studying fungal-plant interactions. Although it produces two types of spores (microconidia and macroconidia), previous infection studies have exclusively dealt with macroconidia. Germination of microconidia has not been reported, and their role in plant infection...

journal_title：Nature communications

authors： Zhang H,Wu Z,Wang C,Li Y,Xu JR

更新日期：2014-08-01 00:00:00

abstract：:Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic and cellular diversity. Here we study the genetic content of 92 indi...

journal_title：Nature communications

authors： Jacobs K,Mertzanidou A,Geens M,Nguyen HT,Staessen C,Spits C

更新日期：2014-06-27 00:00:00

abstract：:The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...

journal_title：Nature communications

authors： Zeng B,Mu G,Luo HQ,Xiang T,Mazin II,Yang H,Shan L,Ren C,Dai PC,Wen HH

更新日期：2010-11-16 00:00:00

abstract：:Mantle plumes are thought to play a key role in transferring heat from the core-mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and henc...

journal_title：Nature communications

authors： Chang SJ,Ferreira AM,Faccenda M

更新日期：2016-02-29 00:00:00

abstract：:According to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, ...

journal_title：Nature communications

authors： Colbeck R,Renner R

更新日期：2011-08-02 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this article. ...

journal_title：Nature communications

authors： Wang Y,Luo G,Liu J,Sankar R,Wang NL,Chou F,Fu L,Li Z

更新日期：2017-10-12 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog...

journal_title：Nature communications

authors： Miller MN,Cheung CYJ,Brainard MS

更新日期：2017-12-13 00:00:00

abstract：:To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...

journal_title：Nature communications

authors： Matsumura T,Sugawara Y,Yutani M,Amatsu S,Yagita H,Kohda T,Fukuoka S,Nakamura Y,Fukuda S,Hase K,Ohno H,Fujinaga Y

更新日期：2015-02-17 00:00:00

abstract：:Competing interactions in the so-called spin-ice compounds stabilize a frustrated ground state with finite zero-point entropy and, interestingly, emergent magnetic monopole excitations. The properties of these monopoles are at the focus of recent research with particular emphasis on their quantum dynamics. It is predi...

journal_title：Nature communications

authors： Grams CP,Valldor M,Garst M,Hemberger J

更新日期：2014-09-04 00:00:00

abstract：:Triboelectrification is a well-known phenomenon that commonly occurs in nature and in our lives at any time and any place. Although each and every material exhibits triboelectrification, its quantification has not been standardized. A triboelectric series has been qualitatively ranked with regards to triboelectric pol...

journal_title：Nature communications

authors： Zou H,Zhang Y,Guo L,Wang P,He X,Dai G,Zheng H,Chen C,Wang AC,Xu C,Wang ZL

更新日期：2019-03-29 00:00:00

abstract：:Novel methods for information processing are highly desired in our information-driven society. Inspired by the brain's ability to process information, the recently introduced paradigm known as 'reservoir computing' shows that complex networks can efficiently perform computation. Here we introduce a novel architecture ...

journal_title：Nature communications

authors： Appeltant L,Soriano MC,Van der Sande G,Danckaert J,Massar S,Dambre J,Schrauwen B,Mirasso CR,Fischer I

更新日期：2011-09-13 00:00:00

abstract：:Boron has become the principle proxy for the release of seawater-derived fluids into arc volcanics, linked to cross-arc variations in boron content and isotopic ratio. Because all ocean floor serpentinites so far analysed are strongly enriched in boron, it is generally assumed that if the uppermost slab mantle is hydr...

journal_title：Nature communications

authors： McCaig AM,Titarenko SS,Savov IP,Cliff RA,Banks D,Boyce A,Agostini S

更新日期：2018-11-02 00:00:00

abstract：:One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where the data only captures a small fraction of the transcriptome of each cell. Almost all computational algorithms developed for single-cell RNA-seq adopted gene selection, dimension reduction or imputation to address the dropouts. H...

journal_title：Nature communications

authors： Qiu P

更新日期：2020-03-03 00:00:00

abstract：:Despite highly promising characteristics of three-dimensionally (3D) nanostructured catalysts for the oxygen evolution reaction (OER) in polymer electrolyte membrane water electrolyzers (PEMWEs), universal design rules for maximizing their performance have not been explored. Here we show that woodpile (WP)-structured ...

journal_title：Nature communications

authors： Kim YJ,Lim A,Kim JM,Lim D,Chae KH,Cho EN,Han HJ,Jeon KU,Kim M,Lee GH,Lee GR,Ahn HS,Park HS,Kim H,Kim JY,Jung YS

更新日期：2020-10-01 00:00:00

abstract：:Evolution of supramolecular chirality from self-assembly of achiral compounds and control over its handedness is closely related to the evolution of life and development of supramolecular materials with desired handedness. Here we report a system where the entire process of induction, control and locking of supramolec...

journal_title：Nature communications

authors： Kim J,Lee J,Kim WY,Kim H,Lee S,Lee HC,Lee YS,Seo M,Kim SY

更新日期：2015-04-23 00:00:00