Flexible and twistable non-volatile memory cell array with all-organic one diode-one resistor architecture.

abstract：:An accurate description of the interaction of intense hard X-ray pulses with heavy atoms, which is crucial for many applications of free-electron lasers, represents a hitherto unresolved challenge for theory because of the enormous number of electronic configurations and relativistic effects, which need to be taken in...

journal_title：Nature communications

authors： Rudek B,Toyota K,Foucar L,Erk B,Boll R,Bomme C,Correa J,Carron S,Boutet S,Williams GJ,Ferguson KR,Alonso-Mori R,Koglin JE,Gorkhover T,Bucher M,Lehmann CS,Krässig B,Southworth SH,Young L,Bostedt C,Ueda K,Marchenk

更新日期：2018-10-10 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with various cellular components of the tumor microenvironment including platelets is crucial for tumor growth and metastasis. Although it is known that platelets can inf...

journal_title：Nature communications

authors： Haemmerle M,Taylor ML,Gutschner T,Pradeep S,Cho MS,Sheng J,Lyons YM,Nagaraja AS,Dood RL,Wen Y,Mangala LS,Hansen JM,Rupaimoole R,Gharpure KM,Rodriguez-Aguayo C,Yim SY,Lee JS,Ivan C,Hu W,Lopez-Berestein G,Wong ST,

更新日期：2017-08-21 00:00:00

abstract：:Electron-positron pair plasmas represent a unique state of matter, whereby there exists an intrinsic and complete symmetry between negatively charged (matter) and positively charged (antimatter) particles. These plasmas play a fundamental role in the dynamics of ultra-massive astrophysical objects and are believed to ...

journal_title：Nature communications

authors： Sarri G,Poder K,Cole JM,Schumaker W,Di Piazza A,Reville B,Dzelzainis T,Doria D,Gizzi LA,Grittani G,Kar S,Keitel CH,Krushelnick K,Kuschel S,Mangles SP,Najmudin Z,Shukla N,Silva LO,Symes D,Thomas AG,Vargas M,Vieir

更新日期：2015-04-23 00:00:00

abstract：:A magnetic impurity coupled to a superconductor gives rise to a Yu-Shiba-Rusinov (YSR) state inside the superconducting energy gap. With increasing exchange coupling the excitation energy of this state eventually crosses zero and the system switches to a YSR ground state with bound quasiparticles screening the impurit...

journal_title：Nature communications

authors： Grove-Rasmussen K,Steffensen G,Jellinggaard A,Madsen MH,Žitko R,Paaske J,Nygård J

更新日期：2018-06-18 00:00:00

abstract：:The mammary gland experiences substantial remodeling and regeneration during development and reproductive life, facilitated by stem cells and progenitors that act in concert with physiological stimuli. While studies have focused on deciphering regenerative cells within the parenchymal epithelium, cell lineages in the ...

journal_title：Nature communications

authors： Joshi PA,Waterhouse PD,Kasaian K,Fang H,Gulyaeva O,Sul HS,Boutros PC,Khokha R

更新日期：2019-04-15 00:00:00

abstract：:Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the receptor ectodomain, th...

journal_title：Nature communications

authors： Weis F,Menting JG,Margetts MB,Chan SJ,Xu Y,Tennagels N,Wohlfart P,Langer T,Müller CW,Dreyer MK,Lawrence MC

更新日期：2018-10-24 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...

journal_title：Nature communications

authors： Chakraborty P,Huang JTJ,Hiom K

更新日期：2018-10-19 00:00:00

abstract：:Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-...

journal_title：Nature communications

authors： Jacquelot N,Roberti MP,Enot DP,Rusakiewicz S,Ternès N,Jegou S,Woods DM,Sodré AL,Hansen M,Meirow Y,Sade-Feldman M,Burra A,Kwek SS,Flament C,Messaoudene M,Duong CPM,Chen L,Kwon BS,Anderson AC,Kuchroo VK,Weide B,Au

更新日期：2017-09-19 00:00:00

abstract：:Environmental challenges to plants typically entail retardation of vegetative growth and delay or cessation of flowering. Here we report a link between the flowering time regulator, GIGANTEA (GI), and adaptation to salt stress that is mechanistically based on GI degradation under saline conditions, thus retarding flow...

journal_title：Nature communications

authors： Kim WY,Ali Z,Park HJ,Park SJ,Cha JY,Perez-Hormaeche J,Quintero FJ,Shin G,Kim MR,Qiang Z,Ning L,Park HC,Lee SY,Bressan RA,Pardo JM,Bohnert HJ,Yun DJ

更新日期：2013-01-01 00:00:00

abstract：:Phospholipase C is a key enzyme in phosphoinositide turnover. Although its functions have been extensively studied at the cellular level, many questions remain concerning its functions at the organ and individual animal levels. Here we demonstrate that mice lacking phospholipase Cδ1 develop granulocytosis associated w...

journal_title：Nature communications

authors： Kanemaru K,Nakamura Y,Sato K,Kojima R,Takahashi S,Yamaguchi M,Ichinohe M,Kiyonari H,Shioi G,Kabashima K,Nakahigashi K,Asagiri M,Jamora C,Yamaguchi H,Fukami K

更新日期：2012-07-17 00:00:00

abstract：:Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use...

journal_title：Nature communications

authors： Woo CW,Schmidt L,Krishnan A,Jepma M,Roy M,Lindquist MA,Atlas LY,Wager TD

更新日期：2017-02-14 00:00:00

abstract：:Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoothened (SMO), which ...

journal_title：Nature communications

authors： Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

更新日期：2017-01-30 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:Proteogenomics enable the discovery of novel peptides (from unannotated genomic protein-coding loci) and single amino acid variant peptides (derived from single-nucleotide polymorphisms and mutations). Increasing the reliability of these identifications is crucial to ensure their usefulness for genome annotation and p...

journal_title：Nature communications

authors： Zhu Y,Orre LM,Johansson HJ,Huss M,Boekel J,Vesterlund M,Fernandez-Woodbridge A,Branca RMM,Lehtiö J

更新日期：2018-03-02 00:00:00

abstract：:The Arctic marine biome, shrinking with increasing temperature and receding sea-ice cover, is tightly connected to lower latitudes through the North Atlantic. By flowing northward through the European Arctic Corridor (the main Arctic gateway where 80% of in- and outflow takes place), the North Atlantic Waters transpor...

journal_title：Nature communications

authors： Oziel L,Baudena A,Ardyna M,Massicotte P,Randelhoff A,Sallée JB,Ingvaldsen RB,Devred E,Babin M

更新日期：2020-04-06 00:00:00

abstract：:While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA ...

journal_title：Nature communications

authors： Wong JJ,Gao D,Nguyen TV,Kwok CT,van Geldermalsen M,Middleton R,Pinello N,Thoeng A,Nagarajah R,Holst J,Ritchie W,Rasko JEJ

更新日期：2017-05-08 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) are effectors of transposable element (TE) silencing in the reproductive apparatus. In Drosophila ovarian somatic cells, piRNAs arise from longer single-stranded RNA precursors that are processed in the cytoplasm presumably within the Yb-bodies. piRNA precursors encoded by the flamenco (...

journal_title：Nature communications

authors： Dennis C,Brasset E,Sarkar A,Vaury C

更新日期：2016-12-08 00:00:00

abstract：:Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explaine...

journal_title：Nature communications

authors： Caswell-Jin JL,McNamara K,Reiter JG,Sun R,Hu Z,Ma Z,Ding J,Suarez CJ,Tilk S,Raghavendra A,Forte V,Chin SF,Bardwell H,Provenzano E,Caldas C,Lang J,West R,Tripathy D,Press MF,Curtis C

更新日期：2019-02-08 00:00:00

abstract：:Many biological processes involve large-scale changes in membrane shape. Computer simulations of these processes are challenging since they occur across a wide range of spatiotemporal scales that cannot be investigated in full by any single current simulation technique. A potential solution is to combine different lev...

journal_title：Nature communications

authors： Pezeshkian W,König M,Wassenaar TA,Marrink SJ

更新日期：2020-05-08 00:00:00

abstract：:Scattering-type scanning near-field optical microscopy (s-SNOM) allows spectroscopic imaging with spatial resolution below the diffraction limit. With suitable light sources, s-SNOM is instrumental in numerous discoveries at the nanoscale. So far, the light sources have been limited to continuous wave or high-repetiti...

journal_title：Nature communications

authors： Wang H,Wang L,Xu XG

更新日期：2016-10-17 00:00:00

abstract：:The ability to suppress unwanted emotional memories is crucial for human mental health. Through consolidation over time, emotional memories often become resistant to change. However, how consolidation impacts the effectiveness of emotional memory suppression is still unknown. Using event-related fMRI while concurrentl...

journal_title：Nature communications

authors： Liu Y,Lin W,Liu C,Luo Y,Wu J,Bayley PJ,Qin S

更新日期：2016-11-29 00:00:00

abstract：:A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de no...

journal_title：Nature communications

authors： Chappell J,Westbrook A,Verosloff M,Lucks JB

更新日期：2017-10-19 00:00:00

abstract：:The unusual electronic properties of diamondoids, the nanoscale relatives of diamond, make them attractive for applications ranging from drug delivery to field emission displays. Identifying the fundamental origin of these properties has proven highly challenging, with even the most advanced quantum many-body calculat...

journal_title：Nature communications

authors： Patrick CE,Giustino F

更新日期：2013-01-01 00:00:00

abstract：:How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is unce...

journal_title：Nature communications

authors： Kim D,Chen R,Sheu M,Kim N,Kim S,Islam N,Wier EM,Wang G,Li A,Park A,Son W,Evans B,Yu V,Prizmic VP,Oh E,Wang Z,Yu J,Huang W,Archer NK,Hu Z,Clemetson N,Nelson AM,Chien A,Okoye GA,Miller LS,Ghiaur G,Kang S

更新日期：2019-06-26 00:00:00

abstract：:Although hexagonal boron nitride (h-BN) is a good candidate for gate-insulating materials by minimizing interaction from substrate, further applications to electronic devices with available two-dimensional semiconductors continue to be limited by flake size. While monolayer h-BN has been synthesized on Pt and Cu foil ...

journal_title：Nature communications

authors： Kim SM,Hsu A,Park MH,Chae SH,Yun SJ,Lee JS,Cho DH,Fang W,Lee C,Palacios T,Dresselhaus M,Kim KK,Lee YH,Kong J

更新日期：2015-10-28 00:00:00

abstract：:Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an un...

journal_title：Nature communications

authors： Pawlowski AC,Wang W,Koteva K,Barton HA,McArthur AG,Wright GD

更新日期：2016-12-08 00:00:00

abstract：:Cell-to-cell variability plays a critical role in cellular responses and decision-making in a population, and transcriptional bursting has been broadly studied by experimental and theoretical approaches as the potential source of cell-to-cell variability. Although molecular mechanisms of transcriptional bursting have ...

journal_title：Nature communications

authors： Fujita K,Iwaki M,Yanagida T

更新日期：2016-12-07 00:00:00

abstract：:Human intestinal bacteria produce butyrate, which has signalling properties and can be used as energy source by enterocytes thus influencing colonic health. However, the pathways and the identity of bacteria involved in this process remain unclear. Here we describe the isolation from the human intestine of Intestinimo...

journal_title：Nature communications

authors： Bui TP,Ritari J,Boeren S,de Waard P,Plugge CM,de Vos WM

更新日期：2015-12-01 00:00:00