Abstract:
:Human intestinal bacteria produce butyrate, which has signalling properties and can be used as energy source by enterocytes thus influencing colonic health. However, the pathways and the identity of bacteria involved in this process remain unclear. Here we describe the isolation from the human intestine of Intestinimonas strain AF211, a bacterium that can convert lysine stoichiometrically into butyrate and acetate when grown in a synthetic medium. Intestinimonas AF211 also converts the Amadori product fructoselysine, which is abundantly formed in heated foods via the Maillard reaction, into butyrate. The butyrogenic pathway includes a specific CoA transferase that is overproduced during growth on lysine. Bacteria related to Intestinimonas AF211 as well as the genetic coding capacity for fructoselysine conversion are abundantly present in colonic samples from some healthy human subjects. Our results indicate that protein can serve as a source of butyrate in the human colon, and its conversion by Intestinimonas AF211 and related butyrogens may protect the host from the undesired side effects of Amadori reaction products.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bui TP,Ritari J,Boeren S,de Waard P,Plugge CM,de Vos WMdoi
10.1038/ncomms10062subject
Has Abstractpub_date
2015-12-01 00:00:00pages
10062issn
2041-1723pii
ncomms10062journal_volume
6pub_type
杂志文章abstract::Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5939
更新日期:2014-09-16 00:00:00
abstract::Preterm infants exhibit different microbiome colonization patterns relative to full-term infants, and it is speculated that the hospital room environment may contribute to infant microbiome development. Here, we present a genome-resolved metagenomic study of microbial genotypes from the gastrointestinal tracts of infa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02018-w
更新日期:2017-11-27 00:00:00
abstract::Analysis of potentially interconnected residential water and energy demand is sparse. In a 1-in-10 random sample of Singapore households living in apartments, water use per capita declines over the socioeconomic distribution, whereas electricity use rises. Here I show that in this leading Asian city and tropical clima...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07833-3
更新日期:2018-12-20 00:00:00
abstract::Emerging evidence suggests that caveolin-1 (Cav1) is associated with pulmonary arterial hypertension. MURC (also called Cavin-4) is a member of the cavin family, which regulates caveolar formation and functions together with caveolins. Here, we show that hypoxia increased Murc mRNA expression in the mouse lung, and th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12417
更新日期:2016-08-22 00:00:00
abstract::Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04613-x
更新日期:2018-06-04 00:00:00
abstract::Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which lead to high-level a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09644-6
更新日期:2019-05-02 00:00:00
abstract::The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular tunnelling junctions, however, lack a gate electrode and suffer from Fermi-level pinning, making it difficult t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12066
更新日期:2016-07-26 00:00:00
abstract::Graphene flakes with giant shape anisotropy are extensively used to establish connectedness electrical percolation in various heterogeneous systems. However, the percolation behaviour of graphene flakes has been recently predicted to be far more complicated than generally anticipated on the basis of excluded volume ar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9700
更新日期:2015-11-16 00:00:00
abstract::TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17097-5
更新日期:2020-07-03 00:00:00
abstract::Continuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05181-w
更新日期:2018-08-03 00:00:00
abstract::Viscous electron fluids have emerged recently as a new paradigm of strongly-correlated electron transport in solids. Here we report on a direct observation of the transition to this long-sought-for state of matter in a high-mobility electron system in graphene. Unexpectedly, the electron flow is found to be interactio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07004-4
更新日期:2018-10-31 00:00:00
abstract::A topological insulator is the state of quantum matter possessing gapless spin-locking surface states across the bulk band gap, which has created new opportunities from novel electronics to energy conversion. However, the large concentration of bulk residual carriers has been a major challenge for revealing the proper...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1771
更新日期:2012-03-27 00:00:00
abstract::Mechanical injury to connective tissue causes changes in collagen structure and material behaviour, but the role and mechanisms of molecular damage have not been established. In the case of mechanical subfailure damage, no apparent macroscale damage can be detected, yet this damage initiates and potentiates in patholo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14913
更新日期:2017-03-22 00:00:00
abstract::Oxygen vacancies in proximity to surfaces and heterointerfaces in oxide thin film heterostructures have major effects on properties, resulting, for example, in emergent conduction behaviour, large changes in metal-insulator transition temperatures or enhanced catalytic activity. Here we report the discovery of a means...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11892
更新日期:2016-06-10 00:00:00
abstract::Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16818-0
更新日期:2020-06-25 00:00:00
abstract::Excessive nitrogen runoff leads to degraded water quality, harming human and ecosystem health. We examine the impact of changes in land use and land management for six combinations of socioeconomic pathways and climate outcomes, and find that societal choices will substantially impact riverine total nitrogen loading (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08884-w
更新日期:2019-02-26 00:00:00
abstract::The expression and stabilization of recombinant proteins is fundamental to basic and applied biology. Here we have engineered a thermostable protein nanoparticle (tES) to improve both expression and stabilization of recombinant proteins using this technology. tES provides steric accommodation and charge complementatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01585-2
更新日期:2017-11-13 00:00:00
abstract::Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3739
更新日期:2013-01-01 00:00:00
abstract::The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important because even at the recommend 30X coverage for reference methylomes, up to 50% of high-resolution fea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11306
更新日期:2016-06-27 00:00:00
abstract::How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00735-w
更新日期:2017-09-25 00:00:00
abstract::Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is regulated by epigenetic modifications remains largely unclear. Here we show that transient histone deacetylati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7830
更新日期:2015-04-23 00:00:00
abstract::Momentum and spin represent fundamental dynamic properties of quantum particles and fields. In particular, propagating optical waves (photons) carry momentum and longitudinal spin determined by the wave vector and circular polarization, respectively. Here we show that exactly the opposite can be the case for evanescen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4300
更新日期:2014-03-06 00:00:00
abstract::Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18860-4
更新日期:2020-10-12 00:00:00
abstract::There is a critical need for standard approaches to assess, report and compare the technical performance of genome-scale differential gene expression experiments. Here we assess technical performance with a proposed standard 'dashboard' of metrics derived from analysis of external spike-in RNA control ratio mixtures. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6125
更新日期:2014-09-25 00:00:00
abstract::India is located at a critical geographic crossroads for understanding the dispersal of Homo sapiens out of Africa and into Asia and Oceania. Here we report evidence for long-term human occupation, spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central India. An unchanging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14668-4
更新日期:2020-02-25 00:00:00
abstract::16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18997-2
更新日期:2020-10-19 00:00:00
abstract::MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3280
更新日期:2013-01-01 00:00:00
abstract::Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15322-9
更新日期:2020-04-14 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths, but its molecular heterogeneity hampers the design of targeted therapies. Currently, the only therapeutic option for advanced HCC is Sorafenib, an inhibitor whose targets include RAF. Unexpectedly, RAF1 expression is reduced in human HCC samples. Mode...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13781
更新日期:2016-12-21 00:00:00
abstract::Metal-organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemica...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12966-0
更新日期:2019-11-01 00:00:00