Abstract:
:Many biological processes involve large-scale changes in membrane shape. Computer simulations of these processes are challenging since they occur across a wide range of spatiotemporal scales that cannot be investigated in full by any single current simulation technique. A potential solution is to combine different levels of resolution through a multiscale scheme. Here, we present a multiscale algorithm that backmaps a continuum membrane model represented as a dynamically triangulated surface (DTS) to its corresponding molecular model based on the coarse-grained (CG) Martini force field. Thus, we can use DTS simulations to equilibrate slow large-scale membrane conformational changes and then explore the local properties at CG resolution. We demonstrate the power of our method by backmapping a vesicular bud induced by binding of Shiga toxin and by transforming the membranes of an entire mitochondrion to near-atomic resolution. Our approach opens the way to whole cell simulations at molecular detail.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Pezeshkian W,König M,Wassenaar TA,Marrink SJdoi
10.1038/s41467-020-16094-ysubject
Has Abstractpub_date
2020-05-08 00:00:00pages
2296issue
1issn
2041-1723pii
10.1038/s41467-020-16094-yjournal_volume
11pub_type
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