Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.

abstract：:The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with uninten...

journal_title：Nature communications

authors： Webber BR,Lonetree CL,Kluesner MG,Johnson MJ,Pomeroy EJ,Diers MD,Lahr WS,Draper GM,Slipek NJ,Smeester BA,Lovendahl KN,McElroy AN,Gordon WR,Osborn MJ,Moriarity BS

更新日期：2019-11-19 00:00:00

abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

journal_title：Nature communications

authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

更新日期：2011-02-15 00:00:00

abstract：:Axially chiral compounds play an important role in areas such as asymmetric catalysis. The tyrosine click-like reaction is an efficient approach for synthesis of urazoles with potential applications in pharmaceutical and asymmetric catalysis. Here we discover a class of urazole with axial chirality by restricted rotat...

journal_title：Nature communications

authors： Zhang JW,Xu JH,Cheng DJ,Shi C,Liu XY,Tan B

更新日期：2016-02-11 00:00:00

abstract：:Magnetic skyrmion, a topologically stable spin-swirling object, can host emergent electromagnetism, as exemplified by the topological Hall effect and electric-current-driven skyrmion motion. To achieve efficient manipulation of nano-sized functional spin textures, it is imperative to exploit the resonant motion of sky...

journal_title：Nature communications

authors： Okamura Y,Kagawa F,Mochizuki M,Kubota M,Seki S,Ishiwata S,Kawasaki M,Onose Y,Tokura Y

更新日期：2013-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors. They can exist and act as dimers, but the requirement of dimers for agonist-induced signal initiation and structural dynamics remains largely unknown. Frizzled 6 (FZD6) is a member of Class F GPCRs, which bind WNT proteins to ...

journal_title：Nature communications

authors： Petersen J,Wright SC,Rodríguez D,Matricon P,Lahav N,Vromen A,Friedler A,Strömqvist J,Wennmalm S,Carlsson J,Schulte G

更新日期：2017-08-09 00:00:00

abstract：:Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

journal_title：Nature communications

authors： Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

更新日期：2016-02-02 00:00:00

abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...

journal_title：Nature communications

authors： Zhang F,Lemaur V,Choi W,Kafle P,Seki S,Cornil J,Beljonne D,Diao Y

更新日期：2019-09-16 00:00:00

abstract：:We present Biomedisa, a free and easy-to-use open-source online platform developed for semi-automatic segmentation of large volumetric images. The segmentation is based on a smart interpolation of sparsely pre-segmented slices taking into account the complete underlying image data. Biomedisa is particularly valuable w...

journal_title：Nature communications

authors： Lösel PD,van de Kamp T,Jayme A,Ershov A,Faragó T,Pichler O,Tan Jerome N,Aadepu N,Bremer S,Chilingaryan SA,Heethoff M,Kopmann A,Odar J,Schmelzle S,Zuber M,Wittbrodt J,Baumbach T,Heuveline V

更新日期：2020-11-04 00:00:00

abstract：:Developing single-site catalysts featuring maximum atom utilization efficiency is urgently desired to improve oxidation-reduction efficiency and cycling capability of lithium-oxygen batteries. Here, we report a green method to synthesize isolated cobalt atoms embedded ultrathin nitrogen-rich carbon as a dual-catalyst ...

journal_title：Nature communications

authors： Wang P,Ren Y,Wang R,Zhang P,Ding M,Li C,Zhao D,Qian Z,Zhang Z,Zhang L,Yin L

更新日期：2020-03-27 00:00:00

abstract：:Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overla...

journal_title：Nature communications

authors： Li J,Jørgensen SF,Maggadottir SM,Bakay M,Warnatz K,Glessner J,Pandey R,Salzer U,Schmidt RE,Perez E,Resnick E,Goldacker S,Buchta M,Witte T,Padyukov L,Videm V,Folseraas T,Atschekzei F,Elder JT,Nair RP,Winkelmann J,

更新日期：2015-04-20 00:00:00

abstract：:The construction of enzyme-inspired artificial catalysts with enzyme-like active sites and microenvironment remains a great challenge. Herein, we report a single-atomic-site Co catalyst supported by carbon doped boron nitride (BCN) with locally polarized B-N bonds (Co SAs/BCN) to simulate the reductive dehalogenases. ...

journal_title：Nature communications

authors： Min Y,Zhou X,Chen JJ,Chen W,Zhou F,Wang Z,Yang J,Xiong C,Wang Y,Li F,Yu HQ,Wu Y

更新日期：2021-01-12 00:00:00

abstract：:In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While lo...

journal_title：Nature communications

authors： Assaraf E,Blecher R,Heinemann-Yerushalmi L,Krief S,Carmel Vinestock R,Biton IE,Brumfeld V,Rotkopf R,Avisar E,Agar G,Zelzer E

更新日期：2020-06-23 00:00:00

abstract：:The circular photogalvanic effect (CPGE) is the part of a photocurrent that switches depending on the sense of circular polarization of the incident light. It has been consistently observed in systems without inversion symmetry and depends on non-universal material details. Here we find that in a class of Weyl semimet...

journal_title：Nature communications

authors： de Juan F,Grushin AG,Morimoto T,Moore JE

更新日期：2017-07-06 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00

abstract：:The integration of nanophotonics and atomic physics has been a long-sought goal that would open new frontiers for optical physics, including novel quantum transport and many-body phenomena with photon-mediated atomic interactions. Reaching this goal requires surmounting diverse challenges in nanofabrication and atomic...

journal_title：Nature communications

authors： Goban A,Hung CL,Yu SP,Hood JD,Muniz JA,Lee JH,Martin MJ,McClung AC,Choi KS,Chang DE,Painter O,Kimble HJ

更新日期：2014-05-08 00:00:00

abstract：:Plasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that...

journal_title：Nature communications

authors： Gessner S,Adli E,Allen JM,An W,Clarke CI,Clayton CE,Corde S,Delahaye JP,Frederico J,Green SZ,Hast C,Hogan MJ,Joshi C,Lindstrøm CA,Lipkowitz N,Litos M,Lu W,Marsh KA,Mori WB,O'Shea B,Vafaei-Najafabadi N,Walz D,Y

更新日期：2016-06-02 00:00:00

abstract：:Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. H...

journal_title：Nature communications

authors： Tasaka GI,Guenthner CJ,Shalev A,Gilday O,Luo L,Mizrahi A

更新日期：2018-02-28 00:00:00

abstract：:Monitoring of protein oligomerization has benefited greatly from Förster Resonance Energy Transfer (FRET) measurements. Although donors and acceptors are typically fluorescent molecules with different spectra, homo-FRET can occur between fluorescent molecules of the same type if the emission spectrum overlaps with the...

journal_title：Nature communications

authors： Ojha N,Rainey KH,Patterson GH

更新日期：2020-01-07 00:00:00

abstract：:The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we use cryo-electron ...

journal_title：Nature communications

authors： Abid Ali F,Renault L,Gannon J,Gahlon HL,Kotecha A,Zhou JC,Rueda D,Costa A

更新日期：2016-02-18 00:00:00

abstract：:The reported progressive change of vegetation activity along elevational gradients has important aesthetic and conservation values. With climate change, cooler locations are suggested to warm faster than warmer ones, raising concerns of a more homogenized landscape along the elevation. Here, we use global satellite da...

journal_title：Nature communications

authors： Gao M,Piao S,Chen A,Yang H,Liu Q,Fu YH,Janssens IA

更新日期：2019-07-05 00:00:00

abstract：:Autophagy, activated by many stresses, plays a critical role in innate immune responses. Here we show that interferon regulatory factor 8 (IRF8) is required for the expression of autophagy-related genes in dendritic cells. Furthermore in macrophages, IRF8 is induced by multiple autophagy-inducing stresses, including I...

journal_title：Nature communications

authors： Gupta M,Shin DM,Ramakrishna L,Goussetis DJ,Platanias LC,Xiong H,Morse HC 3rd,Ozato K

更新日期：2015-03-16 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Radiotherapy is not currently informed by the genetic composition of an individual patient's tumour. To identify genetic features regulating survival after DNA damage, here we conduct large-scale profiling of cellular survival after exposure to radiation in a diverse collection of 533 genetically annotated human tumou...

journal_title：Nature communications

authors： Yard BD,Adams DJ,Chie EK,Tamayo P,Battaglia JS,Gopal P,Rogacki K,Pearson BE,Phillips J,Raymond DP,Pennell NA,Almeida F,Cheah JH,Clemons PA,Shamji A,Peacock CD,Schreiber SL,Hammerman PS,Abazeed ME

更新日期：2016-04-25 00:00:00

abstract：:Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hy...

journal_title：Nature communications

authors： Leibinger M,Zeitler C,Gobrecht P,Andreadaki A,Gisselmann G,Fischer D

更新日期：2021-01-15 00:00:00

abstract：:Memory metamaterials are artificial media that sustain transformed electromagnetic properties without persistent external stimuli. Previous memory metamaterials were realized with phase-change materials, such as vanadium dioxide or chalcogenide glasses, which exhibit memory behaviour with respect to electrically/optic...

journal_title：Nature communications

authors： Kim WY,Kim HD,Kim TT,Park HS,Lee K,Choi HJ,Lee SH,Son J,Park N,Min B

更新日期：2016-01-27 00:00:00

abstract：:In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read 'paternal imprinting' and should have read 'maternal imprinting'. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Zeng Y,Amador C,Xia C,Marioni R,Sproul D,Walker RM,Morris SW,Bretherick A,Canela-Xandri O,Boutin TS,Clark DW,Campbell A,Rawlik K,Hayward C,Nagy R,Tenesa A,Porteous DJ,Wilson JF,Deary IJ,Evans KL,McIntosh AM,Nava

更新日期：2019-05-01 00:00:00

abstract：:Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

journal_title：Nature communications

authors： Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

更新日期：2017-08-02 00:00:00

abstract：:The liquid and glass states of metal-organic frameworks (MOFs) have recently become of interest due to the potential for liquid-phase separations and ion transport, alongside the fundamental nature of the latter as a new, fourth category of melt-quenched glass. Here we show that the MOF liquid state can be blended wit...

journal_title：Nature communications

authors： Longley L,Collins SM,Zhou C,Smales GJ,Norman SE,Brownbill NJ,Ashling CW,Chater PA,Tovey R,Schönlieb CB,Headen TF,Terrill NJ,Yue Y,Smith AJ,Blanc F,Keen DA,Midgley PA,Bennett TD

更新日期：2018-06-15 00:00:00

abstract：:Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies wi...

journal_title：Nature communications

authors： Reuten R,Patel TR,McDougall M,Rama N,Nikodemus D,Gibert B,Delcros JG,Prein C,Meier M,Metzger S,Zhou Z,Kaltenberg J,McKee KK,Bald T,Tüting T,Zigrino P,Djonov V,Bloch W,Clausen-Schaumann H,Poschl E,Yurchenco PD,Eh

更新日期：2016-11-30 00:00:00

abstract：:Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined th...

journal_title：Nature communications

authors： Huda R,Sipe GO,Breton-Provencher V,Cruz KG,Pho GN,Adam E,Gunter LM,Sullins A,Wickersham IR,Sur M

更新日期：2020-11-26 00:00:00