当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.

Abstract：

:While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA methylation at these sites. Accordingly, MeCP2 depletion in tissues and cells enhances IR. By analysing the MeCP2 interactome using mass spectrometry and RNA co-precipitation, we demonstrate that decreased MeCP2 binding near splice junctions facilitates IR via reduced recruitment of splicing factors, including Tra2b, and increased RNA polymerase II stalling. These results suggest an association between IR and a slower rate of transcription elongation, which reflects inefficient splicing factor recruitment. In summary, our results reinforce the interdependency between alternative splicing involving IR and epigenetic controls of gene expression.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wong JJ,Gao D,Nguyen TV,Kwok CT,van Geldermalsen M,Middleton R,Pinello N,Thoeng A,Nagarajah R,Holst J,Ritchie W,Rasko JEJ

doi

10.1038/ncomms15134

subject

Has Abstract

pub_date

2017-05-08 00:00:00

pages

15134

issn

2041-1723

pii

ncomms15134

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Surface tension and contact with soft elastic solids.

    abstract：:The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3728

    authors： Style RW,Hyland C,Boltyanskiy R,Wettlaufer JS,Dufresne ER

    更新日期：2013-01-01 00:00:00

  • The impact of transposable elements on tomato diversity.

    abstract：:Tomatoes come in a multitude of shapes and flavors despite a narrow genetic pool. Here, we leverage whole-genome resequencing data available for 602 cultivated and wild accessions to determine the contribution of transposable elements (TEs) to tomato diversity. We identify 6,906 TE insertions polymorphisms (TIPs), whi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17874-2

    authors： Domínguez M,Dugas E,Benchouaia M,Leduque B,Jiménez-Gómez JM,Colot V,Quadrana L

    更新日期：2020-08-13 00:00:00

  • Janus electrocatalytic flow-through membrane enables highly selective singlet oxygen production.

    abstract：:The importance of singlet oxygen (1O2) in the environmental and biomedical fields has motivated research for effective 1O2 production. Electrocatalytic processes hold great potential for highly-automated and scalable 1O2 synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalyti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20071-w

    authors： Zhao Y,Sun M,Wang X,Wang C,Lu D,Ma W,Kube SA,Ma J,Elimelech M

    更新日期：2020-12-04 00:00:00

  • Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.

    abstract：:Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, leading to more suscep...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14754

    authors： Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL

    更新日期：2017-03-27 00:00:00

  • Publisher Correction: Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers.

    abstract：:The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-019-08907-6

    authors： Zhang W,Zhang D,Chen Q,Wu J,Ouyang Z,Xia Y

    更新日期：2019-02-19 00:00:00

  • Imprintable membranes from incomplete chiral coalescence.

    abstract：:Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4063

    authors： Zakhary MJ,Gibaud T,Kaplan CN,Barry E,Oldenbourg R,Meyer RB,Dogic Z

    更新日期：2014-01-01 00:00:00

  • ERG induces taxane resistance in castration-resistant prostate cancer.

    abstract：:Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the development of drug resistance. In this study, we show that ERG overexpression in in vitro and in viv...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6548

    authors： Galletti G,Matov A,Beltran H,Fontugne J,Miguel Mosquera J,Cheung C,MacDonald TY,Sung M,O'Toole S,Kench JG,Suk Chae S,Kimovski D,Tagawa ST,Nanus DM,Rubin MA,Horvath LG,Giannakakou P,Rickman DS

    更新日期：2014-11-25 00:00:00

  • Three-dimensional self-assembled photonic crystals with high temperature stability for thermal emission modification.

    abstract：:Selective thermal emission in a useful range of energies from a material operating at high temperatures is required for effective solar thermophotovoltaic energy conversion. Three-dimensional metallic photonic crystals can exhibit spectral emissivity that is modified compared with the emissivity of unstructured metals...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3630

    authors： Arpin KA,Losego MD,Cloud AN,Ning H,Mallek J,Sergeant NP,Zhu L,Yu Z,Kalanyan B,Parsons GN,Girolami GS,Abelson JR,Fan S,Braun PV

    更新日期：2013-01-01 00:00:00

  • Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays.

    abstract：:The capability to detect traces of explosives sensitively, selectively and rapidly could be of great benefit for applications relating to civilian national security and military needs. Here, we show that, when chemically modified in a multiplexed mode, nanoelectrical devices arrays enable the supersensitive discrimina...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5195

    authors： Lichtenstein A,Havivi E,Shacham R,Hahamy E,Leibovich R,Pevzner A,Krivitsky V,Davivi G,Presman I,Elnathan R,Engel Y,Flaxer E,Patolsky F

    更新日期：2014-06-24 00:00:00

  • Development of oculomotor circuitry independent of hox3 genes.

    abstract：:Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculom...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5221

    authors： Ma LH,Grove CL,Baker R

    更新日期：2014-06-25 00:00:00

  • The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.

    abstract：:Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10761

    authors： Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X

    更新日期：2016-02-22 00:00:00

  • Fire air pollution reduces global terrestrial productivity.

    abstract：:Fire emissions generate air pollutants ozone (O3) and aerosols that influence the land carbon cycle. Surface O3 damages vegetation photosynthesis through stomatal uptake, while aerosols influence photosynthesis by increasing diffuse radiation. Here we combine several state-of-the-art models and multiple measurement da...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07921-4

    authors： Yue X,Unger N

    更新日期：2018-12-21 00:00:00

  • Non-invasive early detection of cancer four years before conventional diagnosis using a blood test.

    abstract：:Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17316-z

    authors： Chen X,Gole J,Gore A,He Q,Lu M,Min J,Yuan Z,Yang X,Jiang Y,Zhang T,Suo C,Li X,Cheng L,Zhang Z,Niu H,Li Z,Xie Z,Shi H,Zhang X,Fan M,Wang X,Yang Y,Dang J,McConnell C,Zhang J,Wang J,Yu S,Ye W,Gao Y,

    更新日期：2020-07-21 00:00:00

  • Variability in the location of high frequency oscillations during prolonged intracranial EEG recordings.

    abstract：:The rate of interictal high frequency oscillations (HFOs) is a promising biomarker of the seizure onset zone, though little is known about its consistency over hours to days. Here we test whether the highest HFO-rate channels are consistent across different 10-min segments of EEG during sleep. An automated HFO detecto...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04549-2

    authors： Gliske SV,Irwin ZT,Chestek C,Hegeman GL,Brinkmann B,Sagher O,Garton HJL,Worrell GA,Stacey WC

    更新日期：2018-06-01 00:00:00

  • Author Correction: Structural determinants and functional consequences of protein affinity for membrane rafts.

    abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-04164-1

    authors： Lorent JH,Diaz-Rohrer B,Lin X,Spring K,Gorfe AA,Levental KR,Levental I

    更新日期：2018-05-01 00:00:00

  • Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.

    abstract：:Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11610-1

    authors： Vedanayagam J,Chatila WK,Aksoy BA,Majumdar S,Skanderup AJ,Demir E,Schultz N,Sander C,Lai EC

    更新日期：2019-08-15 00:00:00

  • Divergent changes in the elevational gradient of vegetation activities over the last 30 years.

    abstract：:The reported progressive change of vegetation activity along elevational gradients has important aesthetic and conservation values. With climate change, cooler locations are suggested to warm faster than warmer ones, raising concerns of a more homogenized landscape along the elevation. Here, we use global satellite da...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11035-w

    authors： Gao M,Piao S,Chen A,Yang H,Liu Q,Fu YH,Janssens IA

    更新日期：2019-07-05 00:00:00

  • Resonant nanostructures for highly confined and ultra-sensitive surface phonon-polaritons.

    abstract：:Plasmonics on metal-dielectric interfaces was widely seen as the main route for miniaturization of components and interconnect of photonic circuits. However recently, ultra-confined surface phonon-polaritonics in high-index chalcogenide films of nanometric thickness has emerged as an important alternative to plasmonic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15767-y

    authors： Dubrovkin AM,Qiang B,Salim T,Nam D,Zheludev NI,Wang QJ

    更新日期：2020-04-20 00:00:00

  • Spatial and temporal changes in cumulative human impacts on the world's ocean.

    abstract：:Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8615

    authors： Halpern BS,Frazier M,Potapenko J,Casey KS,Koenig K,Longo C,Lowndes JS,Rockwood RC,Selig ER,Selkoe KA,Walbridge S

    更新日期：2015-07-14 00:00:00

  • MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes.

    abstract：:MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14270

    authors： Liu C,Liu R,Zhang D,Deng Q,Liu B,Chao HP,Rycaj K,Takata Y,Lin K,Lu Y,Zhong Y,Krolewski J,Shen J,Tang DG

    更新日期：2017-01-23 00:00:00

  • Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence.

    abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05695-3

    authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

    更新日期：2018-08-17 00:00:00

  • Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10.

    abstract：:The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13021

    authors： Ellenrieder L,Opaliński Ł,Becker L,Krüger V,Mirus O,Straub SP,Ebell K,Flinner N,Stiller SB,Guiard B,Meisinger C,Wiedemann N,Schleiff E,Wagner R,Pfanner N,Becker T

    更新日期：2016-10-10 00:00:00

  • Evidence for dynamic kagome ice.

    abstract：:The search for two-dimensional quantum spin liquids, exotic magnetic states remaining disordered down to zero temperature, has been a great challenge in frustrated magnetism over the last few decades. Recently, evidence for fractionalized excitations, called spinons, emerging from these states has been observed in kag...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06212-2

    authors： Lhotel E,Petit S,Ciomaga Hatnean M,Ollivier J,Mutka H,Ressouche E,Lees MR,Balakrishnan G

    更新日期：2018-09-17 00:00:00

  • Myogenin promotes myocyte fusion to balance fibre number and size.

    abstract：:Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which the transcription factor Myogenin is mutated lack most myogenesis and die perinatally, a specific cell biological role for Myogenin has ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06583-6

    authors： Ganassi M,Badodi S,Ortuste Quiroga HP,Zammit PS,Hinits Y,Hughes SM

    更新日期：2018-10-12 00:00:00

  • Nanoparticles suppress fluid instabilities in the thermal drawing of ultralong nanowires.

    abstract：:Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19796-5

    authors： Hwang I,Guan Z,Cao C,Tang W,Chui CO,Li X

    更新日期：2020-11-23 00:00:00

  • Human seizures couple across spatial scales through travelling wave dynamics.

    abstract：:Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14896

    authors： Martinet LE,Fiddyment G,Madsen JR,Eskandar EN,Truccolo W,Eden UT,Cash SS,Kramer MA

    更新日期：2017-04-04 00:00:00

  • Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

    abstract：:Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7689

    authors： Miyake M,Yamashiro K,Tabara Y,Suda K,Morooka S,Nakanishi H,Khor CC,Chen P,Qiao F,Nakata I,Akagi-Kurashige Y,Gotoh N,Tsujikawa A,Meguro A,Kusuhara S,Polasek O,Hayward C,Wright AF,Campbell H,Richardson AJ,Schache M

    更新日期：2015-03-31 00:00:00

  • Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole.

    abstract：:The yeast Rab5 homologue, Vps21p, is known to be involved both in the vacuolar protein sorting (VPS) pathway from the trans-Golgi network to the vacuole, and in the endocytic pathway from the plasma membrane to the vacuole. However, the intracellular location at which these two pathways converge remains unclear. In ad...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4498

    authors： Toshima JY,Nishinoaki S,Sato Y,Yamamoto W,Furukawa D,Siekhaus DE,Sawaguchi A,Toshima J

    更新日期：2014-03-25 00:00:00

  • Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures.

    abstract：:Bone mineral density (BMD) is a measure of osteoporosis and is useful in evaluating the risk of fracture. In a genome-wide association study of BMD among 20,100 Icelanders, with follow-up in 10,091 subjects of European and East-Asian descent, we found a new BMD locus that harbours the PTCH1 gene, represented by rs2837...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析

    doi：10.1038/ncomms10129

    authors： Styrkarsdottir U,Thorleifsson G,Gudjonsson SA,Sigurdsson A,Center JR,Lee SH,Nguyen TV,Kwok TCY,Lee JSW,Ho SC,Woo J,Leung PC,Kim BJ,Rafnar T,Kiemeney LA,Ingvarsson T,Koh JM,Tang NLS,Eisman JA,Christiansen C,Sigurds

    更新日期：2016-01-06 00:00:00

  • Interactions with conspecific outsiders as drivers of cognitive evolution.

    abstract：:The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...

    journal_title：Nature communications

    pub_type： 杂志文章,评审

    doi：10.1038/s41467-020-18780-3

    authors： Ashton BJ,Kennedy P,Radford AN

    更新日期：2020-10-06 00:00:00