Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila.

abstract：:The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them ...

journal_title：Nature communications

authors： Abolins S,King EC,Lazarou L,Weldon L,Hughes L,Drescher P,Raynes JG,Hafalla JCR,Viney ME,Riley EM

更新日期：2017-05-03 00:00:00

abstract：:The pyridine ring is a potent pharmacophore in alkaloid natural products. Nonetheless, its biosynthetic pathways are poorly understood. Rubrolones A and B are tropolone alkaloid natural products possessing a unique tetra-substituted pyridine moiety. Here, we report the gene cluster and propose a biosynthetic pathway f...

journal_title：Nature communications

authors： Yan Y,Yang J,Yu Z,Yu M,Ma YT,Wang L,Su C,Luo J,Horsman GP,Huang SX

更新日期：2016-10-07 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Writing artificial logic and dynamic function into complex cellular background to achieve desired phenotypes or improved outputs calls for the development of new genetic tools as well as their innovative use. In this study, we present a sensor-regulator and RNAi-based bifunctional dynamic control network that can prov...

journal_title：Nature communications

authors： Yang Y,Lin Y,Wang J,Wu Y,Zhang R,Cheng M,Shen X,Wang J,Chen Z,Li C,Yuan Q,Yan Y

更新日期：2018-08-02 00:00:00

abstract：:One of the fundamental challenges in nanophotonics is to gain full control over nanoscale optical elements. The precise spatiotemporal arrangement determines their interactions and collective behavior. To this end, DNA nanotechnology is employed as an unprecedented tool to create nanophotonic devices with excellent sp...

journal_title：Nature communications

authors： Xin L,Zhou C,Duan X,Liu N

更新日期：2019-11-27 00:00:00

abstract：:The force generated by the actomyosin cytoskeleton controls focal adhesion dynamics during cell migration. This process is thought to involve the mechanical unfolding of talin to expose cryptic vinculin-binding sites. However, the ability of the actomyosin cytoskeleton to directly control the formation of a talin-vinc...

journal_title：Nature communications

authors： Ciobanasu C,Faivre B,Le Clainche C

更新日期：2014-01-01 00:00:00

abstract：:The clockwork of plant circadian oscillators has been resolved through investigations in Arabidopsis thaliana. The circadian oscillator is an important regulator of much of plant physiology, though many of the mechanisms are unclear. New findings demonstrate that the oscillator adjusts phase and period in response to ...

journal_title：Nature communications

authors： Webb AAR,Seki M,Satake A,Caldana C

更新日期：2019-02-01 00:00:00

abstract：:The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Stepanauskas R,Fergusson EA,Brown J,Poulton NJ,Tupper B,Labonté JM,Becraft ED,Brown JM,Pachiadaki MG,Povilaitis T,Thompson BP,Mascena CJ,Bellows WK,Lubys A

更新日期：2017-12-12 00:00:00

abstract：:The interplay between superconductivity and charge-density wave (CDW) in 2H-NbSe2 is not fully understood despite decades of study. Artificially introduced disorder can tip the delicate balance between two competing long-range orders, and reveal the underlying interactions that give rise to them. Here we introduce dis...

journal_title：Nature communications

authors： Cho K,Kończykowski M,Teknowijoyo S,Tanatar MA,Guss J,Gartin PB,Wilde JM,Kreyssig A,McQueeney RJ,Goldman AI,Mishra V,Hirschfeld PJ,Prozorov R

更新日期：2018-07-18 00:00:00

abstract：:Investigating the susceptibility of oestrogen receptor-positive (ER(pos)) normal human breast epithelial cells (HBECs) for clinical purposes or basic research awaits a proficient cell-based assay. Here we set out to identify markers for isolating ER(pos) cells and to expand what appear to be post-mitotic primary cells...

journal_title：Nature communications

authors： Fridriksdottir AJ,Kim J,Villadsen R,Klitgaard MC,Hopkinson BM,Petersen OW,Rønnov-Jessen L

更新日期：2015-11-13 00:00:00

abstract：:Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (...

journal_title：Nature communications

authors： Blomme A,Ford CA,Mui E,Patel R,Ntala C,Jamieson LE,Planque M,McGregor GH,Peixoto P,Hervouet E,Nixon C,Salji M,Gaughan L,Markert E,Repiscak P,Sumpton D,Blanco GR,Lilla S,Kamphorst JJ,Graham D,Faulds K,MacKay GM,

更新日期：2020-05-19 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...

journal_title：Nature communications

authors： Lama L,Adura C,Xie W,Tomita D,Kamei T,Kuryavyi V,Gogakos T,Steinberg JI,Miller M,Ramos-Espiritu L,Asano Y,Hashizume S,Aida J,Imaeda T,Okamoto R,Jennings AJ,Michino M,Kuroita T,Stamford A,Gao P,Meinke P,Glickman

更新日期：2019-05-21 00:00:00

abstract：:Lanthanide compounds show much higher energy barriers to magnetic relaxation than 3d-block compounds, and this has led to speculation that they could be used in molecular spintronic devices. Prototype molecular spin valves and molecular transistors have been reported, with remarkable experiments showing the influence ...

journal_title：Nature communications

authors： Moreno Pineda E,Chilton NF,Marx R,Dörfel M,Sells DO,Neugebauer P,Jiang SD,Collison D,van Slageren J,McInnes EJ,Winpenny RE

更新日期：2014-10-13 00:00:00

abstract：:Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) is now common practice in structural biology. However, it is most of the time applied to rather small oligomeric complexes. Here, we report on the use of HDX-MS to investigate conformational differences between the human standard 20S (std20S) and immuno...

journal_title：Nature communications

authors： Lesne J,Locard-Paulet M,Parra J,Zivković D,Menneteau T,Bousquet MP,Burlet-Schiltz O,Marcoux J

更新日期：2020-12-01 00:00:00

abstract：:Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...

journal_title：Nature communications

authors： Geppert C,Perazza G,Wilson RJ,Bertolli A,Prosser F,Melchiori G,Marini L

更新日期：2020-11-17 00:00:00

abstract：:Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...

journal_title：Nature communications

authors： Wang FY,Yu H,Zou YC,Dai ZG,Cheng KS

更新日期：2017-11-14 00:00:00

abstract：:Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role. Here we show that monocyte-mediated gene delivery of IFNα inhibits l...

journal_title：Nature communications

authors： Escobar G,Barbarossa L,Barbiera G,Norelli M,Genua M,Ranghetti A,Plati T,Camisa B,Brombin C,Cittaro D,Annoni A,Bondanza A,Ostuni R,Gentner B,Naldini L

更新日期：2018-07-24 00:00:00

abstract：:DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...

journal_title：Nature communications

authors： Krishnan S,Ziegler D,Arnaut V,Martin TG,Kapsner K,Henneberg K,Bausch AR,Dietz H,Simmel FC

更新日期：2016-09-23 00:00:00

abstract：:Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and o...

journal_title：Nature communications

authors： Boer CG,Radjabzadeh D,Medina-Gomez C,Garmaeva S,Schiphof D,Arp P,Koet T,Kurilshikov A,Fu J,Ikram MA,Bierma-Zeinstra S,Uitterlinden AG,Kraaij R,Zhernakova A,van Meurs JBJ

更新日期：2019-10-25 00:00:00

abstract：:Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host-microbe interactions. We show that sponges are a reservoir of exceptional microbia...

journal_title：Nature communications

authors： Thomas T,Moitinho-Silva L,Lurgi M,Björk JR,Easson C,Astudillo-García C,Olson JB,Erwin PM,López-Legentil S,Luter H,Chaves-Fonnegra A,Costa R,Schupp PJ,Steindler L,Erpenbeck D,Gilbert J,Knight R,Ackermann G,Victor Lopez

更新日期：2016-06-16 00:00:00

abstract：:Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

journal_title：Nature communications

authors： Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

更新日期：2013-01-01 00:00:00

abstract：:The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reele...

journal_title：Nature communications

authors： Narasimhan S,Schuijt TJ,Abraham NM,Rajeevan N,Coumou J,Graham M,Robson A,Wu MJ,Daffre S,Hovius JW,Fikrig E

更新日期：2017-08-04 00:00:00

abstract：:Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...

journal_title：Nature communications

authors： Jiao L,Zhang R,Wan G,Yang W,Wan X,Zhou H,Shui J,Yu SH,Jiang HL

更新日期：2020-06-05 00:00:00

abstract：:Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not en...

journal_title：Nature communications

authors： Ono T,Okamoto K,Nakashima T,Nitta T,Hori S,Iwakura Y,Takayanagi H

更新日期：2016-03-11 00:00:00

abstract：:Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22)(q34;q11.2) encoding for the BCR-ABL fusion oncogene. However, many molecular mechanisms of the disease progression still remain poorly understood. A growing body of evidence suggests that the epigenetic ...

journal_title：Nature communications

authors： Amabile G,Di Ruscio A,Müller F,Welner RS,Yang H,Ebralidze AK,Zhang H,Levantini E,Qi L,Martinelli G,Brummelkamp T,Le Beau MM,Figueroa ME,Bock C,Tenen DG

更新日期：2015-05-22 00:00:00

abstract：:We present Biomedisa, a free and easy-to-use open-source online platform developed for semi-automatic segmentation of large volumetric images. The segmentation is based on a smart interpolation of sparsely pre-segmented slices taking into account the complete underlying image data. Biomedisa is particularly valuable w...

journal_title：Nature communications

authors： Lösel PD,van de Kamp T,Jayme A,Ershov A,Faragó T,Pichler O,Tan Jerome N,Aadepu N,Bremer S,Chilingaryan SA,Heethoff M,Kopmann A,Odar J,Schmelzle S,Zuber M,Wittbrodt J,Baumbach T,Heuveline V

更新日期：2020-11-04 00:00:00

abstract：:A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as red...

journal_title：Nature communications

authors： Bland-Hawthorn J,Ellis SC,Leon-Saval SG,Haynes R,Roth MM,Löhmannsröben HG,Horton AJ,Cuby JG,Birks TA,Lawrence JS,Gillingham P,Ryder SD,Trinh C

更新日期：2011-12-06 00:00:00

abstract：:The high photon flux and femtosecond pulse duration of hard X-ray free-electron lasers have spurred a large variety of novel and fascinating experiments in physical, chemical and biological sciences. Many of these experiments depend fundamentally on a clean, well-defined wavefront. Here we explore the wavefront proper...

journal_title：Nature communications

authors： Rutishauser S,Samoylova L,Krzywinski J,Bunk O,Grünert J,Sinn H,Cammarata M,Fritz DM,David C

更新日期：2012-07-10 00:00:00

abstract：:The superconducting gap structure in iron-based high-temperature superconductors (Fe-HTSs) is non-universal. In contrast to other unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries are close in energy. Probing the proximity between these very different superconducting sta...

journal_title：Nature communications

authors： Guguchia Z,Amato A,Kang J,Luetkens H,Biswas PK,Prando G,von Rohr F,Bukowski Z,Shengelaya A,Keller H,Morenzoni E,Fernandes RM,Khasanov R

更新日期：2015-11-09 00:00:00

abstract：:Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator to initiate DNA end resection and homologous recombination (HR). Several studies have shown that post-translational modifications control the activity or expression of CtIP. However, it remains unclear whether and how cells restr...

journal_title：Nature communications

authors： Gao M,Guo G,Huang J,Kloeber JA,Zhao F,Deng M,Tu X,Kim W,Zhou Q,Zhang C,Yin P,Luo K,Lou Z

更新日期：2020-10-23 00:00:00