Actomyosin-dependent formation of the mechanosensitive talin-vinculin complex reinforces actin anchoring.

abstract：:Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...

journal_title：Nature communications

authors： Kolarczik M,Owschimikow N,Korn J,Lingnau B,Kaptan Y,Bimberg D,Schöll E,Lüdge K,Woggon U

更新日期：2013-01-01 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special ...

journal_title：Nature communications

authors： Picón A,Lehmann CS,Bostedt C,Rudenko A,Marinelli A,Osipov T,Rolles D,Berrah N,Bomme C,Bucher M,Doumy G,Erk B,Ferguson KR,Gorkhover T,Ho PJ,Kanter EP,Krässig B,Krzywinski J,Lutman AA,March AM,Moonshiram D,Ray D,

更新日期：2016-05-23 00:00:00

abstract：:Photo-activated resin composites are widely used in industry and medicine. Despite extensive chemical characterisation, the micro-scale pattern of resin matrix reactive group conversion between filler particles is not fully understood. Using an advanced synchrotron-based wide-field IR imaging system and state-of-the-a...

journal_title：Nature communications

authors： Sirovica S,Solheim JH,Skoda MWA,Hirschmugl CJ,Mattson EC,Aboualizadeh E,Guo Y,Chen X,Kohler A,Romanyk DL,Rosendahl SM,Morsch S,Martin RA,Addison O

更新日期：2020-04-15 00:00:00

abstract：:High-field magnets of up to tens of teslas in strength advance applications in physics, chemistry and the life sciences. However, progress in generating such high fields has not been matched by corresponding advances in magnetic field measurement. Based mostly on nuclear magnetic resonance, dynamic high-field magnetom...

journal_title：Nature communications

authors： Gross S,Barmet C,Dietrich BE,Brunner DO,Schmid T,Pruessmann KP

更新日期：2016-12-02 00:00:00

abstract：:Semiconducting two-dimensional transition metal dichalcogenides are emerging as top candidates for post-silicon electronics. While most of them exhibit isotropic behaviour, lowering the lattice symmetry could induce anisotropic properties, which are both scientifically interesting and potentially useful. Here we prese...

journal_title：Nature communications

authors： Liu E,Fu Y,Wang Y,Feng Y,Liu H,Wan X,Zhou W,Wang B,Shao L,Ho CH,Huang YS,Cao Z,Wang L,Li A,Zeng J,Song F,Wang X,Shi Y,Yuan H,Hwang HY,Cui Y,Miao F,Xing D

更新日期：2015-05-07 00:00:00

abstract：:A conspicuous 60° bend of the Hawaiian-Emperor Chain in the north-western Pacific Ocean has variously been interpreted as the result of an abrupt Pacific plate motion change in the Eocene (∼47 Ma), a rapid southward drift of the Hawaiian hotspot before the formation of the bend, or a combination of these two causes. P...

journal_title：Nature communications

authors： Torsvik TH,Doubrovine PV,Steinberger B,Gaina C,Spakman W,Domeier M

更新日期：2017-06-05 00:00:00

abstract：:The Mott metal-insulator transition-a manifestation of Coulomb interactions among electrons-is known as a discontinuous transition. Recent theoretical studies, however, suggest that the transition is continuous if the Mott insulator carries a spin liquid with a spinon Fermi surface. Here, we demonstrate the case of a ...

journal_title：Nature communications

authors： Furukawa T,Kobashi K,Kurosaki Y,Miyagawa K,Kanoda K

更新日期：2018-01-22 00:00:00

abstract：:Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1....

journal_title：Nature communications

authors： Ruiz AL,Soudja SM,Deceneux C,Lauvau G,Marie JC

更新日期：2014-10-06 00:00:00

abstract：:Despite their energy-efficient merits as promising light-weight structural materials, magnesium (Mg) based alloys suffer from inadequate corrosion resistance. One primary reason is that the native surface film on Mg formed in air mainly consists of Mg(OH)2 and MgO, which is porous and unprotective, especially in humid...

journal_title：Nature communications

authors： Wang Y,Liu B,Zhao X,Zhang X,Miao Y,Yang N,Yang B,Zhang L,Kuang W,Li J,Ma E,Shan Z

更新日期：2018-10-03 00:00:00

abstract：:Hydrogen, the simplest element in the universe, has a surprisingly complex phase diagram. Because of applications to planetary science, inertial confinement fusion and fundamental physics, its high-pressure properties have been the subject of intense study over the past two decades. While sophisticated static experime...

journal_title：Nature communications

authors： Davis P,Döppner T,Rygg JR,Fortmann C,Divol L,Pak A,Fletcher L,Becker A,Holst B,Sperling P,Redmer R,Desjarlais MP,Celliers P,Collins GW,Landen OL,Falcone RW,Glenzer SH

更新日期：2016-04-15 00:00:00

abstract：:In 2016 the World Health Organization identified 21 countries that could eliminate malaria by 2020. Monitoring progress towards this goal requires tracking ongoing transmission. Here we develop methods that estimate individual reproduction numbers and their variation through time and space. Individual reproduction num...

journal_title：Nature communications

authors： Routledge I,Chevéz JER,Cucunubá ZM,Rodriguez MG,Guinovart C,Gustafson KB,Schneider K,Walker PGT,Ghani AC,Bhatt S

更新日期：2018-06-26 00:00:00

abstract：:Circular RNAs are non-coding RNAs, and are enriched in the CNS. Dorsal horn neurons of the spinal cord contribute to pain-like hypersensitivity after nerve injury in rodents. Here we show that spinal nerve ligation is associated with an increase in expression of circAnks1a in dorsal horn neurons, in both the cytoplasm...

journal_title：Nature communications

authors： Zhang SB,Lin SY,Liu M,Liu CC,Ding HH,Sun Y,Ma C,Guo RX,Lv YY,Wu SL,Xu T,Xin WJ

更新日期：2019-09-11 00:00:00

abstract：:Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...

journal_title：Nature communications

authors： Kernstock S,Davydova E,Jakobsson M,Moen A,Pettersen S,Mælandsmo GM,Egge-Jacobsen W,Falnes PØ

更新日期：2012-01-01 00:00:00

abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...

journal_title：Nature communications

authors： Guixà-González R,Albasanz JL,Rodriguez-Espigares I,Pastor M,Sanz F,Martí-Solano M,Manna M,Martinez-Seara H,Hildebrand PW,Martín M,Selent J

更新日期：2017-02-21 00:00:00

abstract：:The Sun's activity cycle governs the radiation, particle and magnetic flux in the heliosphere creating hazardous space weather. Decadal-scale variations define space climate and force the Earth's atmosphere. However, predicting the solar cycle is challenging. Current understanding indicates a short window for predicti...

journal_title：Nature communications

authors： Bhowmik P,Nandy D

更新日期：2018-12-06 00:00:00

abstract：:The significant degradation that fossilized biomolecules may experience during burial makes it challenging to assess the biogenicity of organic microstructures in ancient rocks. Here we investigate the molecular signatures of 1.88 Ga Gunflint organic microfossils as a function of their diagenetic history. Synchrotron-...

journal_title：Nature communications

authors： Alleon J,Bernard S,Le Guillou C,Marin-Carbonne J,Pont S,Beyssac O,McKeegan KD,Robert F

更新日期：2016-06-17 00:00:00

abstract：:The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit criti...

journal_title：Nature communications

authors： Maturana MI,Meisel C,Dell K,Karoly PJ,D'Souza W,Grayden DB,Burkitt AN,Jiruska P,Kudlacek J,Hlinka J,Cook MJ,Kuhlmann L,Freestone DR

更新日期：2020-05-01 00:00:00

abstract：:Extrachromosomal telomeric circles are commonly invoked as important players in telomere maintenance, but their origin has remained elusive. Using electron microscopy analysis on purified telomeres we show that, apart from known structures, telomeric repeats accumulate internal loops (i-loops) that occur in the proxim...

journal_title：Nature communications

authors： Mazzucco G,Huda A,Galli M,Piccini D,Giannattasio M,Pessina F,Doksani Y

更新日期：2020-10-20 00:00:00

abstract：:The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor ...

journal_title：Nature communications

authors： Feierabend M,Berghäuser G,Knorr A,Malic E

更新日期：2017-03-15 00:00:00

abstract：:The development of stimulus-responsive polymeric materials is of great importance, especially for the development of remotely manipulated materials not in direct contact with an actuator. Here we design a photoresponsive supramolecular actuator by integrating host-guest interactions and photoswitching ability in a hyd...

journal_title：Nature communications

authors： Takashima Y,Hatanaka S,Otsubo M,Nakahata M,Kakuta T,Hashidzume A,Yamaguchi H,Harada A

更新日期：2012-01-01 00:00:00

abstract：:Transition-metal-catalyzed alkene hydrosilylation is one of the most important homogeneous catalytic reactions, and the development of methods that use base metals, especially iron, as catalysts for this transformation is a growing area of research. However, the limited number of ligand scaffolds applicable for base-m...

journal_title：Nature communications

authors： Hu MY,He Q,Fan SJ,Wang ZC,Liu LY,Mu YJ,Peng Q,Zhu SF

更新日期：2018-01-15 00:00:00

abstract：:The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...

journal_title：Nature communications

authors： Wang B,Tan XF,Thurmond S,Zhang ZM,Lin A,Hai R,Song J

更新日期：2017-03-27 00:00:00

abstract：:Using time-domain thermoreflectance, the thermal conductivity and elastic properties of a sputter deposited LiCoO2 film, a common lithium-ion cathode material, are measured as a function of the degree of lithiation. Here we report that via in situ measurements during cycling, the thermal conductivity of a LiCoO2 catho...

journal_title：Nature communications

authors： Cho J,Losego MD,Zhang HG,Kim H,Zuo J,Petrov I,Cahill DG,Braun PV

更新日期：2014-06-03 00:00:00

abstract：:Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic polyketide with antib...

journal_title：Nature communications

authors： Zhao M,Zhao Y,Yao M,Iqbal H,Hu Q,Liu H,Qiao B,Li C,Skovbjerg CAS,Nielsen JC,Nielsen J,Frandsen RJN,Yuan Y,Boeke JD

更新日期：2020-12-03 00:00:00

abstract：:Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct...

journal_title：Nature communications

authors： Gräff J,Woldemichael BT,Berchtold D,Dewarrat G,Mansuy IM

更新日期：2012-01-01 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:India is located at a critical geographic crossroads for understanding the dispersal of Homo sapiens out of Africa and into Asia and Oceania. Here we report evidence for long-term human occupation, spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central India. An unchanging...

journal_title：Nature communications

authors： Clarkson C,Harris C,Li B,Neudorf CM,Roberts RG,Lane C,Norman K,Pal J,Jones S,Shipton C,Koshy J,Gupta MC,Mishra DP,Dubey AK,Boivin N,Petraglia M

更新日期：2020-02-25 00:00:00

abstract：:Ferroelectric domain walls constitute a completely new class of sheet-like functional material. Moreover, since domain walls are generally writable, erasable and mobile, they could be useful in functionally agile devices: for example, creating and moving conducting walls could make or break electrical connections in n...

journal_title：Nature communications

authors： McQuaid RGP,Campbell MP,Whatmore RW,Kumar A,Gregg JM

更新日期：2017-05-16 00:00:00

abstract：:Regulation of protein N-glycosylation is essential in human cells. However, large-scale, accurate, and site-specific quantification of glycosylation is still technically challenging. We here introduce SugarQuant, an integrated mass spectrometry-based pipeline comprising protein aggregation capture (PAC)-based sample p...

journal_title：Nature communications

authors： Fang P,Ji Y,Silbern I,Doebele C,Ninov M,Lenz C,Oellerich T,Pan KT,Urlaub H

更新日期：2020-10-19 00:00:00