Origin of micro-scale heterogeneity in polymerisation of photo-activated resin composites.

abstract：:Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide re...

journal_title：Nature communications

authors： Lawrence MG,Schäfer S,Muri H,Scott V,Oschlies A,Vaughan NE,Boucher O,Schmidt H,Haywood J,Scheffran J

更新日期：2018-09-13 00:00:00

abstract：:The behavior of uranium in environments, ranging from those of natural systems responsible for the formation of uranium deposits to those of nuclear reactors providing 11% of the world's electricity, is governed by processes involving high-temperature aqueous solutions. It has been well documented that uranium is mobi...

journal_title：Nature communications

authors： Timofeev A,Migdisov AA,Williams-Jones AE,Roback R,Nelson AT,Xu H

更新日期：2018-04-16 00:00:00

abstract：:Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. Although H2BK120ub triggers several critical downstream histone modification pathways and changes in chromatin structure, less is known about the ...

journal_title：Nature communications

authors： Wojcik F,Dann GP,Beh LY,Debelouchina GT,Hofmann R,Muir TW

更新日期：2018-04-11 00:00:00

abstract：:Molecular photoswitches provide an extremely simple solution for solar energy conversion and storage. To convert stored energy to electricity, however, the photoswitch has to be coupled to a semiconducting electrode. In this work, we report on the assembly of an operational solar-energy-storing organic-oxide hybrid in...

journal_title：Nature communications

authors： Schuschke C,Hohner C,Jevric M,Ugleholdt Petersen A,Wang Z,Schwarz M,Kettner M,Waidhas F,Fromm L,Sumby CJ,Görling A,Brummel O,Moth-Poulsen K,Libuda J

更新日期：2019-06-03 00:00:00

abstract：:To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...

journal_title：Nature communications

authors： Espah Borujeni A,Zhang J,Doosthosseini H,Nielsen AAK,Voigt CA

更新日期：2020-10-05 00:00:00

abstract：:Water is a complex liquid that displays a surprising array of unusual properties, the most famous being the density maximum at about 4 °C. The origin of these anomalies is still a matter of debate, and so far a quantitative description of water's phase behaviour starting from the molecular arrangements is still missin...

journal_title：Nature communications

authors： Russo J,Tanaka H

更新日期：2014-04-02 00:00:00

abstract：:RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

journal_title：Nature communications

authors： Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

更新日期：2018-09-10 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:Australopithecus sediba has been hypothesized to be a close relative of the genus Homo. Here we show that MH1, the type specimen of A. sediba, was not optimized to produce high molar bite force and appears to have been limited in its ability to consume foods that were mechanically challenging to eat. Dental microwear ...

journal_title：Nature communications

authors： Ledogar JA,Smith AL,Benazzi S,Weber GW,Spencer MA,Carlson KB,McNulty KP,Dechow PC,Grosse IR,Ross CF,Richmond BG,Wright BW,Wang Q,Byron C,Carlson KJ,de Ruiter DJ,Berger LR,Tamvada K,Pryor LC,Berthaume MA,Strait DS

更新日期：2016-02-08 00:00:00

abstract：:Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also phosphorylates p38 to inactivate N...

journal_title：Nature communications

authors： Shen Y,Song Z,Lu X,Ma Z,Lu C,Zhang B,Chen Y,Duan M,Apetoh L,Li X,Guo J,Miao Y,Zhang G,Yang D,Cai Z,Wang J

更新日期：2019-07-02 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...

journal_title：Nature communications

authors： Besenbacher S,Liu S,Izarzugaza JM,Grove J,Belling K,Bork-Jensen J,Huang S,Als TD,Li S,Yadav R,Rubio-García A,Lescai F,Demontis D,Rao J,Ye W,Mailund T,Friborg RM,Pedersen CN,Xu R,Sun J,Liu H,Wang O,Cheng X,Fl

更新日期：2015-01-19 00:00:00

abstract：:The large interest in chiral magnetic structures for realization of nanoscale magnetic storage or logic devices has necessitated methods which can quantify magnetic interactions at the atomic scale. To overcome the limitations of the typically used current-based sensing of atomic-scale exchange interactions, a force-b...

journal_title：Nature communications

authors： Hauptmann N,Haldar S,Hung TC,Jolie W,Gutzeit M,Wegner D,Heinze S,Khajetoorians AA

更新日期：2020-03-05 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing ...

journal_title：Nature communications

authors： Wang XM,Lu Y,Song YM,Dong J,Li RY,Wang GL,Wang X,Zhang SD,Dong ZH,Lu M,Wang SY,Ge LY,Luo GD,Ma RZ,George Rozen S,Bai F,Wu D,Ma LL

更新日期：2020-02-06 00:00:00

abstract：:Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...

journal_title：Nature communications

authors： Weierstall U,James D,Wang C,White TA,Wang D,Liu W,Spence JC,Bruce Doak R,Nelson G,Fromme P,Fromme R,Grotjohann I,Kupitz C,Zatsepin NA,Liu H,Basu S,Wacker D,Han GW,Katritch V,Boutet S,Messerschmidt M,Williams GJ

更新日期：2014-01-01 00:00:00

abstract：:Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...

journal_title：Nature communications

authors： Russell JK,Edwards BR,Porritt LA

更新日期：2013-01-01 00:00:00

abstract：:A key element enabling the microelectronic technology advances of the past decades has been the conceptualization of complex circuits with versatile functionalities as being composed of the proper combination of basic 'lumped' circuit elements (for example, inductors and capacitors). In contrast, modern nanophotonic s...

journal_title：Nature communications

authors： Shi J,Monticone F,Elias S,Wu Y,Ratchford D,Li X,Alù A

更新日期：2014-05-29 00:00:00

abstract：:Topological defects in nematic liquid crystals are ubiquitous. The defects are important in understanding the fundamental properties of the systems, as well as in practical applications, such as colloidal self-assembly, optical vortex generation and templates for molecular self-assembly. Usually, spatially and tempora...

journal_title：Nature communications

authors： Sasaki Y,Jampani VSR,Tanaka C,Sakurai N,Sakane S,Le KV,Araoka F,Orihara H

更新日期：2016-11-07 00:00:00

abstract：:Between the land and ocean, diverse coastal ecosystems transform, store, and transport material. Across these interfaces, the dynamic exchange of energy and matter is driven by hydrological and hydrodynamic processes such as river and groundwater discharge, tides, waves, and storms. These dynamics regulate ecosystem f...

journal_title：Nature communications

authors： Ward ND,Megonigal JP,Bond-Lamberty B,Bailey VL,Butman D,Canuel EA,Diefenderfer H,Ganju NK,Goñi MA,Graham EB,Hopkinson CS,Khangaonkar T,Langley JA,McDowell NG,Myers-Pigg AN,Neumann RB,Osburn CL,Price RM,Rowland J,Sen

更新日期：2020-05-18 00:00:00

abstract：:MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...

journal_title：Nature communications

authors： Alivernini S,Kurowska-Stolarska M,Tolusso B,Benvenuto R,Elmesmari A,Canestri S,Petricca L,Mangoni A,Fedele AL,Di Mario C,Gigante MR,Gremese E,McInnes IB,Ferraccioli G

更新日期：2016-09-27 00:00:00

abstract：:Following re-sequencing of the miSFIT constructs used in the paper, two of the construct variants inserted into the 3'UTR of PD-1, namely '12C' and '17A, 18G', have been found to contain additional insertions not present in the other construct variants. The data points corresponding to these constructs in Figs. 2c, f ...

journal_title：Nature communications

authors： Michaels YS,Barnkob MB,Barbosa H,Baeumler TA,Thompson MK,Andre V,Colin-York H,Fritzsche M,Gileadi U,Sheppard HM,Knapp DJHF,Milne TA,Cerundolo V,Fulga TA

更新日期：2019-06-10 00:00:00

abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

journal_title：Nature communications

authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

更新日期：2018-02-02 00:00:00

abstract：:TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contrast to its closest s...

journal_title：Nature communications

authors： Demircioglu FE,Zheng W,McQuown AJ,Maier NK,Watson N,Cheeseman IM,Denic V,Egelman EH,Schwartz TU

更新日期：2019-07-22 00:00:00

abstract：:The transcriptional regulatory network (TRN) of Bacillus subtilis coordinates cellular functions of fundamental interest, including metabolism, biofilm formation, and sporulation. Here, we use unsupervised machine learning to modularize the transcriptome and quantitatively describe regulatory activity under diverse co...

journal_title：Nature communications

authors： Rychel K,Sastry AV,Palsson BO

更新日期：2020-12-11 00:00:00

abstract：:Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothri...

journal_title：Nature communications

authors： Voronina N,Wong JKL,Hübschmann D,Hlevnjak M,Uhrig S,Heilig CE,Horak P,Kreutzfeldt S,Mock A,Stenzinger A,Hutter B,Fröhlich M,Brors B,Jahn A,Klink B,Gieldon L,Sieverling L,Feuerbach L,Chudasama P,Beck K,Kroiss M,H

更新日期：2020-05-08 00:00:00

abstract：:Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available...

journal_title：Nature communications

authors： Li H,Dong B,Zhang X,Shu X,Chen X,Hai R,Czaplewski DA,Zhang HF,Sun C

更新日期：2019-09-19 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity, learning and memory, and are implicated in various neuronal disorders. We synthesized a diffusible photochromic glutamate analogue, azobenzene-triazole-glutamate (ATG), which is specific for NMDARs and functions as a photoswitchable ag...

journal_title：Nature communications

authors： Laprell L,Repak E,Franckevicius V,Hartrampf F,Terhag J,Hollmann M,Sumser M,Rebola N,DiGregorio DA,Trauner D

更新日期：2015-08-27 00:00:00

abstract：:Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promot...

journal_title：Nature communications

authors： Kolesnikova O,Ben-Shem A,Luo J,Ranish J,Schultz P,Papai G

更新日期：2018-11-07 00:00:00

abstract：:FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic purposes and demonstrate its utility on the example of two use cases. We...

journal_title：Nature communications

authors： Sichtig H,Minogue T,Yan Y,Stefan C,Hall A,Tallon L,Sadzewicz L,Nadendla S,Klimke W,Hatcher E,Shumway M,Aldea DL,Allen J,Koehler J,Slezak T,Lovell S,Schoepp R,Scherf U

更新日期：2019-07-25 00:00:00

abstract：:Phase transitions in amorphous alloys under pressure are an important fundamental problem. Here we report on a first-principles study that reproduces the recently discovered pressure-induced crystallization of amorphous Ce100-xAlx (x<25) alloys and reveals an atomistic transformation mechanism. Contrary to common beli...

journal_title：Nature communications

authors： Wu M,Tse JS,Wang SY,Wang CZ,Jiang JZ

更新日期：2015-03-09 00:00:00