Mechanical evidence that Australopithecus sediba was limited in its ability to eat hard foods.

abstract：:Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific expression analysi...

journal_title：Nature communications

authors： Litchfield K,Reading JL,Lim EL,Xu H,Liu P,Al-Bakir M,Wong YNS,Rowan A,Funt SA,Merghoub T,Perkins D,Lauss M,Svane IM,Jönsson G,Herrero J,Larkin J,Quezada SA,Hellmann MD,Turajlic S,Swanton C

更新日期：2020-07-30 00:00:00

abstract：:Coordination between osteoblasts and osteoclasts is required for bone health and homeostasis. Here we show that mice deficient in SMURF2 have severe osteoporosis in vivo. This low bone mass phenotype is accompanied by a pronounced increase in osteoclast numbers, although Smurf2-deficient osteoclasts have no intrinsic ...

journal_title：Nature communications

authors： Xu Z,Greenblatt MB,Yan G,Feng H,Sun J,Lotinun S,Brady N,Baron R,Glimcher LH,Zou W

更新日期：2017-02-20 00:00:00

abstract：:The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conform...

journal_title：Nature communications

authors： Harris AR,Jreij P,Belardi B,Joffe AM,Bausch AR,Fletcher DA

更新日期：2020-11-25 00:00:00

abstract：:The cell adhesion molecule Neuroligin2 (NL2) is localized selectively at GABAergic synapses, where it interacts with the scaffolding protein gephyrin in the post-synaptic density. However, the role of this interaction for formation and plasticity of GABAergic synapses is unclear. Here, we demonstrate that endogenous N...

journal_title：Nature communications

authors： Antonelli R,Pizzarelli R,Pedroni A,Fritschy JM,Del Sal G,Cherubini E,Zacchi P

更新日期：2014-10-09 00:00:00

abstract：:Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for ...

journal_title：Nature communications

authors： Antony AN,Paillard M,Moffat C,Juskeviciute E,Correnti J,Bolon B,Rubin E,Csordás G,Seifert EL,Hoek JB,Hajnóczky G

更新日期：2016-03-09 00:00:00

abstract：:There is a critical need for standard approaches to assess, report and compare the technical performance of genome-scale differential gene expression experiments. Here we assess technical performance with a proposed standard 'dashboard' of metrics derived from analysis of external spike-in RNA control ratio mixtures. ...

journal_title：Nature communications

authors： Munro SA,Lund SP,Pine PS,Binder H,Clevert DA,Conesa A,Dopazo J,Fasold M,Hochreiter S,Hong H,Jafari N,Kreil DP,Łabaj PP,Li S,Liao Y,Lin SM,Meehan J,Mason CE,Santoyo-Lopez J,Setterquist RA,Shi L,Shi W,Smyth GK,

更新日期：2014-09-25 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) initiates both antibody class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. DNA double-strand break response (DSBR) factors promote rearrangement in CSR, while translesion synthesis (TLS) polymerases generate mutations in SHM. REV7, ...

journal_title：Nature communications

authors： Yang D,Sun Y,Chen J,Zhang Y,Fan S,Huang M,Xie X,Cai Y,Shang Y,Gui T,Sun L,Hu J,Dong J,Yeap LS,Wang X,Xiao W,Meng FL

更新日期：2020-06-04 00:00:00

abstract：:Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but f...

journal_title：Nature communications

authors： Huang W,Peng Y,Kiselar J,Zhao X,Albaqami A,Mendez D,Chen Y,Chakravarthy S,Gupta S,Ralston C,Kao HY,Chance MR,Yang S

更新日期：2018-08-30 00:00:00

abstract：:DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the...

journal_title：Nature communications

authors： Liu J,Zhu Y,Luo GZ,Wang X,Yue Y,Wang X,Zong X,Chen K,Yin H,Fu Y,Han D,Wang Y,Chen D,He C

更新日期：2016-10-07 00:00:00

abstract：:Efficient crop improvement depends on the application of accurate genetic information contained in diverse germplasm resources. Here we report a reference-grade genome of wild soybean accession W05, with a final assembled genome size of 1013.2 Mb and a contig N50 of 3.3 Mb. The analytical power of the W05 genome is de...

journal_title：Nature communications

authors： Xie M,Chung CY,Li MW,Wong FL,Wang X,Liu A,Wang Z,Leung AK,Wong TH,Tong SW,Xiao Z,Fan K,Ng MS,Qi X,Yang L,Deng T,He L,Chen L,Fu A,Ding Q,He J,Chung G,Isobe S,Tanabata T,Valliyodan B,Nguyen HT,Cannon SB

更新日期：2019-03-14 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:The elastic-to-plastic transition during the deformation of a dislocation-free nanoscale volume is accompanied by displacement bursts associated with dislocation nucleation. The dislocations that nucleate during the so-called "pop-in" burst take the form of prismatic dislocation loops (PDLs) and exhibit characteristic...

journal_title：Nature communications

authors： Lee S,Vaid A,Im J,Kim B,Prakash A,Guénolé J,Kiener D,Bitzek E,Oh SH

更新日期：2020-05-12 00:00:00

abstract：:Extrachromosomal telomeric circles are commonly invoked as important players in telomere maintenance, but their origin has remained elusive. Using electron microscopy analysis on purified telomeres we show that, apart from known structures, telomeric repeats accumulate internal loops (i-loops) that occur in the proxim...

journal_title：Nature communications

authors： Mazzucco G,Huda A,Galli M,Piccini D,Giannattasio M,Pessina F,Doksani Y

更新日期：2020-10-20 00:00:00

abstract：:Angiogenesis is a necessary process for solid tumor growth. Cellular markers for endothelial cell proliferation are potential targets for identifying the vasculature of tumors in homeostasis. Here we customize the behaviors of engineered cells to recognize Apj, a surface marker of the neovascular endothelium, using sy...

journal_title：Nature communications

authors： Wang Z,Wang F,Zhong J,Zhu T,Zheng Y,Zhao T,Xie Q,Ma F,Li R,Tang Q,Xu F,Tian X,Zhu J

更新日期：2020-05-01 00:00:00

abstract：:Manipulation of nonlinear waves in artificial periodic structures leads to spectacular spatial features, such as generation of gap solitons or onset of the Mott insulator phase transition. Cavity exciton-polaritons are strongly interacting quasiparticles offering large possibilities for potential optical technologies....

journal_title：Nature communications

authors： Tanese D,Flayac H,Solnyshkov D,Amo A,Lemaître A,Galopin E,Braive R,Senellart P,Sagnes I,Malpuech G,Bloch J

更新日期：2013-01-01 00:00:00

abstract：:The welding and sintering of nanomaterials is relevant, for example, to form electrical contacts between metallic particles in printed electronic devices. Usually the welding of nanoparticles is achieved at high temperatures. Here we find that merging of two different metals, silver and gold nanoparticles, occurs on c...

journal_title：Nature communications

authors： Grouchko M,Roitman P,Zhu X,Popov I,Kamyshny A,Su H,Magdassi S

更新日期：2014-01-01 00:00:00

abstract：:Plasmonics on metal-dielectric interfaces was widely seen as the main route for miniaturization of components and interconnect of photonic circuits. However recently, ultra-confined surface phonon-polaritonics in high-index chalcogenide films of nanometric thickness has emerged as an important alternative to plasmonic...

journal_title：Nature communications

authors： Dubrovkin AM,Qiang B,Salim T,Nam D,Zheludev NI,Wang QJ

更新日期：2020-04-20 00:00:00

abstract：:Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endorib...

journal_title：Nature communications

authors： Yang JY,Deng XY,Li YS,Ma XC,Feng JX,Yu B,Chen Y,Luo YL,Wang X,Chen ML,Fang ZX,Zheng FX,Li YP,Zhong Q,Kang TB,Song LB,Xu RH,Zeng MS,Chen W,Zhang H,Xie W,Gao S

更新日期：2018-03-21 00:00:00

abstract：:Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...

journal_title：Nature communications

authors： Wang X,Hatzoglou C,Sneed B,Fan Z,Guo W,Jin K,Chen D,Bei H,Wang Y,Weber WJ,Zhang Y,Gault B,More KL,Vurpillot F,Poplawsky JD

更新日期：2020-02-24 00:00:00

abstract：:Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associa...

journal_title：Nature communications

authors： Uyoga S,Macharia AW,Ndila CM,Nyutu G,Shebe M,Awuondo KO,Mturi N,Peshu N,Tsofa B,Scott JAG,Maitland K,Williams TN

更新日期：2019-02-20 00:00:00

abstract：:The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural kil...

journal_title：Nature communications

authors： Bruel T,Guivel-Benhassine F,Amraoui S,Malbec M,Richard L,Bourdic K,Donahue DA,Lorin V,Casartelli N,Noël N,Lambotte O,Mouquet H,Schwartz O

更新日期：2016-03-03 00:00:00

abstract：:Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal surfaces. Her...

journal_title：Nature communications

authors： Thimsen E,Johnson M,Zhang X,Wagner AJ,Mkhoyan KA,Kortshagen UR,Aydil ES

更新日期：2014-12-19 00:00:00

abstract：:CDKL5 deficiency disorder (CDD) is characterized by epilepsy, intellectual disability, and autistic features, and CDKL5-deficient mice exhibit a constellation of behavioral phenotypes reminiscent of the human disorder. We previously found that CDKL5 dysfunction in forebrain glutamatergic neurons results in deficits in...

journal_title：Nature communications

authors： Tang S,Terzic B,Wang IJ,Sarmiento N,Sizov K,Cui Y,Takano H,Marsh ED,Zhou Z,Coulter DA

更新日期：2019-06-14 00:00:00

abstract：:High-performance piezoelectrics are lead-based solid solutions that exhibit a so-called morphotropic phase boundary, which separates two competing phases as a function of chemical composition; as a consequence, an intermediate low-symmetry phase with a strong piezoelectric effect arises. In search for environmentally ...

journal_title：Nature communications

authors： Lummen TT,Gu Y,Wang J,Lei S,Xue F,Kumar A,Barnes AT,Barnes E,Denev S,Belianinov A,Holt M,Morozovska AN,Kalinin SV,Chen LQ,Gopalan V

更新日期：2014-01-01 00:00:00

abstract：:In most applications of nanoporous materials the pore structure is as important as the chemical composition as a determinant of performance. For example, one can alter performance in applications like carbon capture or methane storage by orders of magnitude by only modifying the pore structure. For these applications ...

journal_title：Nature communications

authors： Lee Y,Barthel SD,Dłotko P,Moosavi SM,Hess K,Smit B

更新日期：2017-05-23 00:00:00

abstract：:The dynamics of an order parameter's amplitude and phase determines the collective behaviour of novel states emerging in complex materials. Time- and momentum-resolved pump-probe spectroscopy, by virtue of measuring material properties at atomic and electronic time scales out of equilibrium, can decouple entangled deg...

journal_title：Nature communications

authors： Lee WS,Chuang YD,Moore RG,Zhu Y,Patthey L,Trigo M,Lu DH,Kirchmann PS,Krupin O,Yi M,Langner M,Huse N,Robinson JS,Chen Y,Zhou SY,Coslovich G,Huber B,Reis DA,Kaindl RA,Schoenlein RW,Doering D,Denes P,Schlotter WF

更新日期：2012-05-15 00:00:00

abstract：:Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the intracellular sign...

journal_title：Nature communications

authors： Nakaya M,Tajima M,Kosako H,Nakaya T,Hashimoto A,Watari K,Nishihara H,Ohba M,Komiya S,Tani N,Nishida M,Taniguchi H,Sato Y,Matsumoto M,Tsuda M,Kuroda M,Inoue K,Kurose H

更新日期：2013-01-01 00:00:00

abstract：:A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...

journal_title：Nature communications

authors： Stoffel MA,Humble E,Paijmans AJ,Acevedo-Whitehouse K,Chilvers BL,Dickerson B,Galimberti F,Gemmell NJ,Goldsworthy SD,Nichols HJ,Krüger O,Negro S,Osborne A,Pastor T,Robertson BC,Sanvito S,Schultz JK,Shafer ABA,Wolf JBW

更新日期：2018-11-16 00:00:00

abstract：:Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...

journal_title：Nature communications

authors： Endo K,Liu Y,Ube H,Nagata K,Shionoya M

更新日期：2020-12-09 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00