Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.

Abstract:

:DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.

journal_name

Nat Commun

journal_title

Nature communications

authors

Liu J,Zhu Y,Luo GZ,Wang X,Yue Y,Wang X,Zong X,Chen K,Yin H,Fu Y,Han D,Wang Y,Chen D,He C

doi

10.1038/ncomms13052

subject

Has Abstract

pub_date

2016-10-07 00:00:00

pages

13052

issn

2041-1723

pii

ncomms13052

journal_volume

7

pub_type

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