Abstract:
:DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu J,Zhu Y,Luo GZ,Wang X,Yue Y,Wang X,Zong X,Chen K,Yin H,Fu Y,Han D,Wang Y,Chen D,He Cdoi
10.1038/ncomms13052subject
Has Abstractpub_date
2016-10-07 00:00:00pages
13052issn
2041-1723pii
ncomms13052journal_volume
7pub_type
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