Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.

abstract：:Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate re...

journal_title：Nature communications

authors： Kim TH,Wang Y,Oliver CR,Thamm DH,Cooling L,Paoletti C,Smith KJ,Nagrath S,Hayes DF

更新日期：2019-04-01 00:00:00

abstract：:Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...

journal_title：Nature communications

authors： Perunicic VS,Hill CD,Hall LT,Hollenberg LC

更新日期：2016-10-11 00:00:00

abstract：:The modern energy economy and environmental infrastructure rely on the flow of fluids through fractures in rock. Yet this flow cannot be imaged directly because rocks are opaque to most probes. Here we apply chattering dust, or chemically reactive grains of sucrose containing pockets of pressurized carbon dioxide, to ...

journal_title：Nature communications

authors： Pyrak-Nolte LJ,Braverman W,Nolte NJ,Wright AJ,Nolte DD

更新日期：2020-10-19 00:00:00

abstract：:The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...

journal_title：Nature communications

authors： Manjavacas A,García de Abajo FJ

更新日期：2014-03-27 00:00:00

abstract：:The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...

journal_title：Nature communications

authors： Liu J,van der Zee B,Alessandri R,Sami S,Dong J,Nugraha MI,Barker AJ,Rousseva S,Qiu L,Qiu X,Klasen N,Chiechi RC,Baran D,Caironi M,Anthopoulos TD,Portale G,Havenith RWA,Marrink SJ,Hummelen JC,Koster LJA

更新日期：2020-11-10 00:00:00

abstract：:Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mechanism is not clear...

journal_title：Nature communications

authors： Peng Y,Liao Q,Tan W,Peng C,Hu Z,Chen Y,Li Z,Li J,Zhen B,Zhu W,Li X,Yao Y,Song Q,Liu C,Qi X,He F,Pei H

更新日期：2019-03-15 00:00:00

abstract：:Discarding by fisheries is perceived as contrary to responsible harvesting. Legislation seeking to end the practice is being introduced in many jurisdictions. However, discarded fish are food for a range of scavenging species; so, ending discarding may have ecological consequences. Here we investigate the sensitivity ...

journal_title：Nature communications

authors： Heath MR,Cook RM,Cameron AI,Morris DJ,Speirs DC

更新日期：2014-05-13 00:00:00

abstract：:X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a dis...

journal_title：Nature communications

authors： Luijk R,Wu H,Ward-Caviness CK,Hannon E,Carnero-Montoro E,Min JL,Mandaviya P,Müller-Nurasyid M,Mei H,van der Maarel SM,BIOS Consortium.,Relton C,Mill J,Waldenberger M,Bell JT,Jansen R,Zhernakova A,Franke L,'t Hoen PAC

更新日期：2018-09-14 00:00:00

abstract：:Ferroelectric materials exhibit a phase transition to a paraelectric state driven by temperature - called the Curie transition. In conventional ferroelectrics, the Curie transition is caused by a change in crystal symmetry, while the material itself remains a continuous three-dimensional solid crystal. However, ferroe...

journal_title：Nature communications

authors： Hafner J,Benaglia S,Richheimer F,Teuschel M,Maier FJ,Werner A,Wood S,Platz D,Schneider M,Hradil K,Castro FA,Garcia R,Schmid U

更新日期：2021-01-08 00:00:00

abstract：:Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigger for lateral opening of the translocon is not known. Here we monitor lateral opening by photo-induced electron transfe...

journal_title：Nature communications

authors： Ge Y,Draycheva A,Bornemann T,Rodnina MV,Wintermeyer W

更新日期：2014-10-15 00:00:00

abstract：:Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for ...

journal_title：Nature communications

authors： Antony AN,Paillard M,Moffat C,Juskeviciute E,Correnti J,Bolon B,Rubin E,Csordás G,Seifert EL,Hoek JB,Hajnóczky G

更新日期：2016-03-09 00:00:00

abstract：:Alkaline-urea aqueous solvent system provides a novel and important approach for the utilization of polysaccharide. As one of the most important polysaccharide, chitosan can be well dissolved in this solvent system, and the resultant hydrogel material possesses unique and excellent properties. Thus the sound understan...

journal_title：Nature communications

authors： Wang Z,Nie J,Qin W,Hu Q,Tang BZ

更新日期：2016-06-23 00:00:00

abstract：:In higher plants, the hormone auxin orchestrates a diverse array of developmental and environmental responses mainly exerted via transcriptional control. In its absence, auxin-mediated transcription is postulated to be repressed by histone deacetylases, which convert chromatin into a highly packed inactive state. Here...

journal_title：Nature communications

authors： Weiste C,Dröge-Laser W

更新日期：2014-05-27 00:00:00

abstract：:HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...

journal_title：Nature communications

authors： Zhu B,Xiao Y,Yeager M,Clifford G,Wentzensen N,Cullen M,Boland JF,Bass S,Steinberg MK,Raine-Bennett T,Lee D,Burk RD,Pinheiro M,Song L,Dean M,Nelson CW,Burdett L,Yu K,Roberson D,Lorey T,Franceschi S,Castle PE,Wa

更新日期：2020-02-14 00:00:00

abstract：:HIV persists in latently infected CD4+ T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remains unknown. Using CD4+...

journal_title：Nature communications

authors： Fromentin R,DaFonseca S,Costiniuk CT,El-Far M,Procopio FA,Hecht FM,Hoh R,Deeks SG,Hazuda DJ,Lewin SR,Routy JP,Sékaly RP,Chomont N

更新日期：2019-02-18 00:00:00

abstract：:Synthetic DNA is becoming an attractive substrate for digital data storage due to its density, durability, and relevance in biological research. A major challenge in making DNA data storage a reality is that reading DNA back into data using sequencing by synthesis remains a laborious, slow and expensive process. Here,...

journal_title：Nature communications

authors： Lopez R,Chen YJ,Dumas Ang S,Yekhanin S,Makarychev K,Racz MZ,Seelig G,Strauss K,Ceze L

更新日期：2019-07-03 00:00:00

abstract：:Nanophotonics is becoming invaluable for an expanding range of applications, from controlling the spontaneous emission rate and the directionality of quantum emitters, to reducing material requirements of solar cells by an order of magnitude. These effects are highly dependent on the near field of the nanostructure, w...

journal_title：Nature communications

authors： Johlin E,Solari J,Mann SA,Wang J,Shimizu TS,Garnett EC

更新日期：2016-12-20 00:00:00

abstract：:A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs)...

journal_title：Nature communications

authors： Wan WL,Tian B,Lin YJ,Korupalli C,Lu MY,Cui Q,Wan D,Chang Y,Sung HW

更新日期：2020-01-27 00:00:00

abstract：:Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium...

journal_title：Nature communications

authors： Yuan Y,Zhan C,He K,Chen H,Yao W,Sharifi-Asl S,Song B,Yang Z,Nie A,Luo X,Wang H,Wood SM,Amine K,Islam MS,Lu J,Shahbazian-Yassar R

更新日期：2016-11-21 00:00:00

abstract：:Fluorescence imaging is one of the most versatile and widely used visualization methods in biomedical research. However, tissue autofluorescence is a major obstacle confounding interpretation of in vivo fluorescence images. The unusually long emission lifetime (5-13 μs) of photoluminescent porous silicon nanoparticles...

journal_title：Nature communications

authors： Gu L,Hall DJ,Qin Z,Anglin E,Joo J,Mooney DJ,Howell SB,Sailor MJ

更新日期：2013-01-01 00:00:00

abstract：:Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...

journal_title：Nature communications

authors： Mirzamohammadi F,Papaioannou G,Inloes JB,Rankin EB,Xie H,Schipani E,Orkin SH,Kobayashi T

更新日期：2016-06-22 00:00:00

abstract：:The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit criti...

journal_title：Nature communications

authors： Maturana MI,Meisel C,Dell K,Karoly PJ,D'Souza W,Grayden DB,Burkitt AN,Jiruska P,Kudlacek J,Hlinka J,Cook MJ,Kuhlmann L,Freestone DR

更新日期：2020-05-01 00:00:00

abstract：:The 2018 summit and flank eruption of Kīlauea Volcano was one of the largest volcanic events in Hawai'i in 200 years. Data suggest that a backup in the magma plumbing system at the long-lived Pu'u 'Ō'ō eruption site caused widespread pressurization in the volcano, driving magma into the lower flank. The eruption evolv...

journal_title：Nature communications

authors： Patrick MR,Houghton BF,Anderson KR,Poland MP,Montgomery-Brown E,Johanson I,Thelen W,Elias T

更新日期：2020-11-06 00:00:00

abstract：:Socioeconomic challenges continue to mount for half a billion residents of central India because of a decline in the total rainfall and a concurrent rise in the magnitude and frequency of extreme rainfall events. Alongside a weakening monsoon circulation, the locally available moisture and the frequency of moisture-la...

journal_title：Nature communications

authors： Roxy MK,Ghosh S,Pathak A,Athulya R,Mujumdar M,Murtugudde R,Terray P,Rajeevan M

更新日期：2017-10-03 00:00:00

abstract：:Recently, it has been shown that animals such as jumping spiders, birds, and butterflies have evolved ultra-black coloration comparable to the blackest synthetic materials. Of these, certain papilionid butterflies have reflectances approaching 0.2%, resulting from a polydisperse honeycomb structure. It is unknown if o...

journal_title：Nature communications

authors： Davis AL,Nijhout HF,Johnsen S

更新日期：2020-03-10 00:00:00

abstract：:Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...

journal_title：Nature communications

authors： Rosales BA,Mundt LE,Allen TG,Moore DT,Prince KJ,Wolden CA,Rumbles G,Schelhas LT,Wheeler LM

更新日期：2020-10-16 00:00:00

abstract：:Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecul...

journal_title：Nature communications

authors： Chavali M,Klingener M,Kokkosis AG,Garkun Y,Felong S,Maffei A,Aguirre A

更新日期：2018-01-02 00:00:00

abstract：:Express delivery services are booming in both developed and emerging economies due to their low cost, convenience, and the fast growth in online shopping. The increasing environmental impacts of express delivery services and mitigation potentials, however, remain largely unexplored. Here we addressed such a gap for Ch...

journal_title：Nature communications

authors： Kang P,Song G,Xu M,Miller TR,Wang H,Zhang H,Liu G,Zhou Y,Ren J,Zhong R,Duan H

更新日期：2021-01-19 00:00:00

abstract：:While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA ...

journal_title：Nature communications

authors： Wong JJ,Gao D,Nguyen TV,Kwok CT,van Geldermalsen M,Middleton R,Pinello N,Thoeng A,Nagarajah R,Holst J,Ritchie W,Rasko JEJ

更新日期：2017-05-08 00:00:00

abstract：:Light trapping across a wide band of frequencies is important for applications such as solar cells and photodetectors. Here, we demonstrate a new approach to light management by forming whispering-gallery resonant modes inside a spherical nanoshell structure. The geometry of the structure gives rise to a low quality-f...

journal_title：Nature communications

authors： Yao Y,Yao J,Narasimhan VK,Ruan Z,Xie C,Fan S,Cui Y

更新日期：2012-02-07 00:00:00