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A quantum spin-probe molecular microscope.

Abstract：

:Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule using a quantum spin probe acting simultaneously as the magnetic resonance sensor and source of magnetic field gradient. Signals corresponding to specific regions of the molecule's nuclear spin density are encoded on the quantum state of the probe, which is used to produce a 3D image of the molecular structure. Quantum simulations of the protocol applied to the rapamycin molecule (C51H79NO13) show that the hydrogen and carbon substructure can be imaged at the angstrom level using current spin-probe technology. With prospects for scaling to large molecules and/or fast dynamic conformation mapping using spin labels, this method provides a realistic pathway for single-molecule microscopy.

journal_name

Nat Commun

journal_title

Nature communications

authors

Perunicic VS,Hill CD,Hall LT,Hollenberg LC

doi

10.1038/ncomms12667

subject

Has Abstract

pub_date

2016-10-11 00:00:00

pages

12667

issn

2041-1723

pii

ncomms12667

journal_volume

7

pub_type

杂志文章

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