Abstract:
:FoxO proteins are major targets of insulin action. To better define the role of FoxO1 in mediating insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice. Here we show that LIRKO mice are severely insulin resistant based on glucose, insulin and C-peptide levels, and glucose and insulin tolerance tests, and genetic deletion of hepatic FoxO1 reverses these effects. (13)C-glucose and insulin clamp studies indicate that regulation of both hepatic glucose production (HGP) and glucose utilization is impaired in LIRKO mice, and these defects are also restored in LIRFKO mice corresponding to changes in gene expression. We conclude that (1) inhibition of FoxO1 is critical for both direct (hepatic) and indirect effects of insulin on HGP and utilization, and (2) extrahepatic effects of insulin are sufficient to maintain normal whole-body and hepatic glucose metabolism when liver FoxO1 activity is disrupted.
journal_name
Nat Communjournal_title
Nature communicationsauthors
O-Sullivan I,Zhang W,Wasserman DH,Liew CW,Liu J,Paik J,DePinho RA,Stolz DB,Kahn CR,Schwartz MW,Unterman TGdoi
10.1038/ncomms8079subject
Has Abstractpub_date
2015-05-12 00:00:00pages
7079issn
2041-1723pii
ncomms8079journal_volume
6pub_type
杂志文章abstract::The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3342
更新日期:2013-01-01 00:00:00
abstract::Surface charge density is the key factor for developing high performance triboelectric nanogenerators (TENG). The previously invented charge excitation TENG provides a most efficient way to achieve maximum charge output of a TENG device. Herein, criteria to quantitatively evaluate the contact efficiency and air breakd...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15368-9
更新日期:2020-03-27 00:00:00
abstract::Bright solitons are non-dispersive wave solutions, arising in a diverse range of nonlinear, one-dimensional systems, including atomic Bose-Einstein condensates with attractive interactions. In reality, cold-atom experiments can only approach the idealized one-dimensional limit necessary for the realization of true sol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2893
更新日期:2013-01-01 00:00:00
abstract::The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03815-7
更新日期:2018-04-16 00:00:00
abstract::Solution-processable perovskites show highly emissive and good charge transport, making them attractive for low-cost light-emitting diodes (LEDs) with high energy conversion efficiencies. Despite recent advances in device efficiency, the stability of perovskite LEDs is still a major obstacle. Here, we demonstrate stab...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11567-1
更新日期:2019-08-09 00:00:00
abstract::The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequenc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1276
更新日期:2011-01-01 00:00:00
abstract::Chirality is an intriguing property of certain molecules, materials or artificial nanostructures, which allows them to interact with the spin angular momentum of the impinging light field. Due to their chiral geometry, they can distinguish between left- and right-hand circular polarization states or convert them into ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13117
更新日期:2016-10-13 00:00:00
abstract::γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell recepto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14760
更新日期:2017-03-01 00:00:00
abstract::Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9261
更新日期:2015-09-18 00:00:00
abstract::It has previously been shown that the relative reliability of model-based and model-free reinforcement-learning (RL) systems plays a role in the allocation of behavioral control between them. However, the role of task complexity in the arbitration between these two strategies remains largely unknown. Here, using a com...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13632-1
更新日期:2019-12-16 00:00:00
abstract::Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of pan-resistant Gram-negative bacteria. Here, we show that mcr-1 confers resistance to colistin-induced lysis and bacterial cell death, but provides minimal protection from the ability of colistin to disrupt the Gram-negative oute...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02875-z
更新日期:2018-01-31 00:00:00
abstract::Pulse oximetry is a ubiquitous non-invasive medical sensing method for measuring pulse rate and arterial blood oxygenation. Conventional pulse oximeters use expensive optoelectronic components that restrict sensing locations to finger tips or ear lobes due to their rigid form and area-scaling complexity. In this work,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6745
更新日期:2014-12-10 00:00:00
abstract::Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14737-8
更新日期:2020-02-21 00:00:00
abstract::Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15667-1
更新日期:2020-04-14 00:00:00
abstract::Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08903-w
更新日期:2019-03-21 00:00:00
abstract::Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06471-z
更新日期:2018-09-27 00:00:00
abstract::Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through a multi-step end-on conversion process. Upstream regulators that orchestrate this remarkable change in the plane of kinetochore-microtubule attachment in human cells are not kno...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00209-z
更新日期:2017-07-28 00:00:00
abstract::Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage. Molecular mechanism(s) underlying such homology-dependent pairing phenomena remain(s) unknown. Using Neurospora crassa repeat-induced point mutation (RIP) as a model ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4509
更新日期:2014-04-03 00:00:00
abstract::Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors underlying both processes still poorly understood. Here we show that transport and positioning of lat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11808
更新日期:2016-06-10 00:00:00
abstract::Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability sca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14625-1
更新日期:2020-02-14 00:00:00
abstract::The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1636
更新日期:2012-01-10 00:00:00
abstract::Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15472-w
更新日期:2020-05-08 00:00:00
abstract::The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05104-9
更新日期:2018-07-23 00:00:00
abstract::Thousands of tons of isotopic mixtures are processed annually for heavy-water production and tritium decontamination. The existing technologies remain extremely energy intensive and require large capital investments. New approaches are needed to reduce the industry's footprint. Recently, micrometre-size crystals of gr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15215
更新日期:2017-05-09 00:00:00
abstract::The charge density wave in the high-temperature superconductor YBa2Cu3O7-x (YBCO) has two different ordering tendencies differentiated by their c-axis correlations. These correspond to ferro- (F-CDW) and antiferro- (AF-CDW) couplings between CDWs in neighbouring CuO2 bilayers. This discovery has prompted several funda...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14536-1
更新日期:2020-02-20 00:00:00
abstract::How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11444-x
更新日期:2019-08-08 00:00:00
abstract::Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01708-9
更新日期:2017-11-16 00:00:00
abstract::Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channels. Here, the author...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14324-x
更新日期:2020-01-23 00:00:00
abstract::Artificial molecules containing just one or two electrons provide a powerful platform for studies of orbital and spin quantum dynamics in nanoscale devices. A well-known example of these dynamics is tunnelling of electrons between two coupled quantum dots triggered by mi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1561
更新日期:2011-11-22 00:00:00
abstract::Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12314-2
更新日期:2019-09-18 00:00:00