Abstract:
:Pulse oximetry is a ubiquitous non-invasive medical sensing method for measuring pulse rate and arterial blood oxygenation. Conventional pulse oximeters use expensive optoelectronic components that restrict sensing locations to finger tips or ear lobes due to their rigid form and area-scaling complexity. In this work, we report a pulse oximeter sensor based on organic materials, which are compatible with flexible substrates. Green (532 nm) and red (626 nm) organic light-emitting diodes (OLEDs) are used with an organic photodiode (OPD) sensitive at the aforementioned wavelengths. The sensor's active layers are deposited from solution-processed materials via spin-coating and printing techniques. The all-organic optoelectronic oximeter sensor is interfaced with conventional electronics at 1 kHz and the acquired pulse rate and oxygenation are calibrated and compared with a commercially available oximeter. The organic sensor accurately measures pulse rate and oxygenation with errors of 1% and 2%, respectively.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lochner CM,Khan Y,Pierre A,Arias ACdoi
10.1038/ncomms6745subject
Has Abstractpub_date
2014-12-10 00:00:00pages
5745issn
2041-1723pii
ncomms6745journal_volume
5pub_type
杂志文章abstract::Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-retromer assembly for ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06114-3
更新日期:2018-09-13 00:00:00
abstract::Engineering strong metal-support interactions (SMSI) is an effective strategy for tuning structures and performances of supported metal catalysts but induces poor exposure of active sites. Here, we demonstrate a strong metal-support interaction via a reverse route (SMSIR) by starting from the final morphology of SMSI ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16674-y
更新日期:2020-06-16 00:00:00
abstract::Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13595-3
更新日期:2019-12-06 00:00:00
abstract::The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6964
更新日期:2015-01-20 00:00:00
abstract::Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01131-0
更新日期:2017-10-24 00:00:00
abstract::FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic purposes and demonstrate its utility on the example of two use cases. We...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11306-6
更新日期:2019-07-25 00:00:00
abstract::Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transgene, commonly used to target the mammary gland during pregnancy, indu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15585-2
更新日期:2020-04-14 00:00:00
abstract::Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitize...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9065
更新日期:2015-08-25 00:00:00
abstract::Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with various cellular components of the tumor microenvironment including platelets is crucial for tumor growth and metastasis. Although it is known that platelets can inf...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00411-z
更新日期:2017-08-21 00:00:00
abstract::Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19880-w
更新日期:2020-12-01 00:00:00
abstract::Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19684-y
更新日期:2020-11-17 00:00:00
abstract::Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6129
更新日期:2014-10-09 00:00:00
abstract::The separation of immiscible liquids has significant implications for magma evolution and the formation of magmatic ore deposits. We combine high-resolution imaging and electron probe microanalysis with the first use of atom probe tomography on tholeiitic basaltic glass from Hawaii, the Snake River Plain, and Iceland,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12694-5
更新日期:2019-10-23 00:00:00
abstract::BKM120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer, but it interferes as an off-target effect with microtubule polymerization. Here, we developed two chemical derivatives that differ from BKM120 by only one atom. We show that these minute changes sep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14683
更新日期:2017-03-09 00:00:00
abstract::Whole-genome sequencing using sequencing technologies such as Illumina enables the accurate detection of small-scale variants but provides limited information about haplotypes and variants in repetitive regions of the human genome. Single-molecule sequencing (SMS) technologies such as Pacific Biosciences and Oxford Na...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12493-y
更新日期:2019-10-11 00:00:00
abstract::The advent and growth of synthetic biology has demonstrated its potential as a promising avenue of research to address many societal needs. However, plant synthetic biology efforts have been hampered by a dearth of DNA part libraries, versatile transformation vectors and efficient assembly strategies. Here, we describ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13215
更新日期:2016-10-26 00:00:00
abstract::For many stochastic processes, the probability [Formula: see text] of not-having reached a target in unbounded space up to time [Formula: see text] follows a slow algebraic decay at long times, [Formula: see text]. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10841-6
更新日期:2019-07-05 00:00:00
abstract::Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This process transfers the latent magnetism of para-hydrogen into a substrate, without changing its chemical identity, to dramatically improve its nuclear ma...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06766-1
更新日期:2018-10-12 00:00:00
abstract::Black phosphorus, a fast emerging two-dimensional material, has been configured as field effect transistors, showing a hole-transport-dominated ambipolar characteristic. Here we report an effective modulation on ambipolar characteristics of few-layer black phosphorus transistors through in situ surface functionalizati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7485
更新日期:2015-03-12 00:00:00
abstract::Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15757
更新日期:2017-06-01 00:00:00
abstract::Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease virus (NDV), in add...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14340
更新日期:2017-02-13 00:00:00
abstract::Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01133-y
更新日期:2017-10-18 00:00:00
abstract::Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion of group A or B cells into O cells has been ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8451
更新日期:2015-06-16 00:00:00
abstract::Non-Abelian quasiparticles have been predicted to exist in a variety of condensed matter systems. Their defining property is that an adiabatic braid between two of them results in a non-trivial change of the quantum state of the system. The simplest non-Abelian quasiparticles--the Majorana bound states--can occur in o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10395
更新日期:2016-01-21 00:00:00
abstract::The degraded, misfolded C terminus of TAR DNA-binding protein-43 is associated with a wide spectrum of neurodegenerative diseases, particularly frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. However, the precise mechanism of pathological cleavage of the TAR DNA-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1766
更新日期:2012-04-03 00:00:00
abstract::Coordination of ciliary beating is essential to ensure mucus clearance in the airway tract. The orientation and synchronization of ciliary motion responds in part to the organization of the underlying cytoskeletal networks. Using electron tomography on mouse trachea, we show that basal bodies are collectively hooked a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5888
更新日期:2014-09-12 00:00:00
abstract::The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13679
更新日期:2016-11-24 00:00:00
abstract::Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) able to correlate the levels of multiple signalling, differentiation and cell fate markers. Immunofluorescence (IF) microscopy add...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9390
更新日期:2015-09-24 00:00:00
abstract::In nature, individual cells contain multiple isolated compartments in which cascade enzymatic reactions occur to form essential biological products with high efficiency. Here, we report a cell-inspired design of functional hydrogel particles with multiple compartments, in which different enzymes are spatially immobili...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00757-4
更新日期:2017-09-22 00:00:00
abstract::YUCCA (YUC) proteins constitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesis. Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accum...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9041
更新日期:2015-08-28 00:00:00