Abstract:
:Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malignant hepatocytes. We find that two critical enzymes 11β-HSD1 and 11β-HSD2 that regulate glucocorticoid activities are expressed inversely in malignant hepatocytes, resulting in the inactivation of endogenous glucocorticoids and the loss of gluconeogenesis. In patients' hepatocarcinoma, the expression of 11β-HSD1 and 11β-HSD2 is closely linked to prognosis and survival. Dexamethasone, an active form of synthesized glucocorticoids, is capable of restoring gluconeogenesis in malignant cells by bypassing the abnormal regulation of 11β-HSD enzymes, leading to therapeutic efficacy against hepatocarcinoma. These findings clarify the molecular basis of malignant hepatocyte loss of gluconeogenesis and suggest new therapeutic strategies.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ma R,Zhang W,Tang K,Zhang H,Zhang Y,Li D,Li Y,Xu P,Luo S,Cai W,Ji T,Katirai F,Ye D,Huang Bdoi
10.1038/ncomms3508subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2508issn
2041-1723pii
ncomms3508journal_volume
4pub_type
杂志文章abstract::Chirality is an intriguing property of certain molecules, materials or artificial nanostructures, which allows them to interact with the spin angular momentum of the impinging light field. Due to their chiral geometry, they can distinguish between left- and right-hand circular polarization states or convert them into ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13117
更新日期:2016-10-13 00:00:00
abstract::Nanocrystal quantum dots are attractive materials for applications as nanoscale light sources. One impediment to these applications is fluctuations of single-dot emission intensity, known as blinking. Recent progress in colloidal synthesis has produced nonblinking nanocrystals; however, the physics underlying blinking...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1916
更新日期:2012-06-19 00:00:00
abstract::The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the v...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12393
更新日期:2016-08-10 00:00:00
abstract::Symmetry-breaking phase transitions are an example of non-equilibrium processes that require real-time treatment, a major challenge in strongly coupled systems without long-lived quasiparticles. Holographic duality provides such an approach by mapping strongly coupled field theories in D dimensions into weakly coupled...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8406
更新日期:2015-06-23 00:00:00
abstract::Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble org...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15269
更新日期:2017-05-19 00:00:00
abstract::The process of crystallization is difficult to observe for transported, out-of-equilibrium systems, as the continuous energy injection increases activity and competes with ordering. In emerging fields such as microfluidics and active matter, the formation of long-range order is often frustrated by the presence of hydr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10255-4
更新日期:2019-06-04 00:00:00
abstract::Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19043-x
更新日期:2020-10-23 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is insufficient to cause disease, suggests other co-factors are involved. Here we present epidemiolog...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17696-2
更新日期:2020-07-31 00:00:00
abstract::Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are dist...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2910
更新日期:2013-01-01 00:00:00
abstract::Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet, infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence has been attributed to viral replication in an ART sanctuary and long-lived and/or proliferating latently infected cells. Using ecologic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06843-5
更新日期:2018-11-16 00:00:00
abstract::Marine reserves are viewed as flagship tools to protect exploited species and to contribute to the effective management of coastal fisheries. Yet, the extent to which marine reserves are globally interconnected and able to effectively seed areas, where fisheries are most critical for food and livelihood security is la...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16039
更新日期:2017-07-10 00:00:00
abstract::Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicula...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15855-z
更新日期:2020-04-24 00:00:00
abstract::Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9260
更新日期:2015-10-06 00:00:00
abstract::Stable water isotope records from Antarctica are key for our understanding of Quaternary climate variations. However, the exact quantitative interpretation of these important climate proxy records in terms of surface temperature, ice sheet height and other climatic changes is still a matter of debate. Here we report r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05430-y
更新日期:2018-08-30 00:00:00
abstract::The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11013-2
更新日期:2019-07-24 00:00:00
abstract::A prerequisite to myelination of peripheral axons by Schwann cells (SCs) is SC differentiation, and recent evidence indicates that reprogramming from a glycolytic to oxidative metabolism occurs during cellular differentiation. Whether this reprogramming is essential for SC differentiation, and the genes that regulate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5993
更新日期:2014-09-26 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-14820-0
更新日期:2020-02-21 00:00:00
abstract::Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01698-8
更新日期:2017-11-14 00:00:00
abstract::The degradation of intrinsic properties of graphene during the transfer process constitutes a major challenge in graphene device fabrication, stimulating the need for direct growth of graphene on dielectric substrates. Previous attempts of metal-induced transformation of diamond and silicon carbide into graphene suffe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12099
更新日期:2016-07-04 00:00:00
abstract::Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung ca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09762-1
更新日期:2019-04-16 00:00:00
abstract::In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12469
更新日期:2016-08-24 00:00:00
abstract::Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12652-1
更新日期:2019-10-22 00:00:00
abstract::The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13679
更新日期:2016-11-24 00:00:00
abstract::Ferroelectric domain walls constitute a completely new class of sheet-like functional material. Moreover, since domain walls are generally writable, erasable and mobile, they could be useful in functionally agile devices: for example, creating and moving conducting walls could make or break electrical connections in n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15105
更新日期:2017-05-16 00:00:00
abstract::Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03683-1
更新日期:2018-04-03 00:00:00
abstract::The hydroxyl radical (OH) removes most atmospheric pollutants from air. The loss frequency of OH radicals due to the combined effect of all gas-phase OH reactive species is a measureable quantity termed total OH reactivity. Here we present total OH reactivity observations in pristine Amazon rainforest air, as a functi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10383
更新日期:2016-01-22 00:00:00
abstract::Van Allen radiation belts consist of relativistic electrons trapped by Earth's magnetic field. Trapped electrons often drift azimuthally around Earth and display a butterfly pitch angle distribution of a minimum at 90° further out than geostationary orbit. This is usually attributed to drift shell splitting resulting ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9590
更新日期:2015-10-05 00:00:00
abstract::Binary transition metal dichalcogenide monolayers share common properties such as a direct optical bandgap, spin-orbit splittings of hundreds of meV, light-matter interaction dominated by robust excitons and coupled spin-valley states. Here we demonstrate spin-orbit-engineering in Mo(1-x)WxSe2 alloy monolayers for opt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10110
更新日期:2015-12-14 00:00:00
abstract::Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19840-4
更新日期:2020-11-25 00:00:00
abstract::Understanding and extracting the full functions of single-molecule characteristics are key factors in the development of future device technologies, as well as in basic research on molecular electronics. Here we report a new methodology for realizing a three-dimensional (3D) dynamic probe of single-molecule conductanc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9465
更新日期:2015-10-06 00:00:00