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Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients.

Abstract：

:Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell signatures is found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared with squamous cell carcinoma (SQCC, 54.4%). The correlation of genomic alterations with immune signatures reveals that low immune infiltration was associated with EGFR mutations in ADC samples, PI3K and/or WNT pathway activation in SQCC. While KRAS mutations are found to be significantly associated with T cell infiltration in ADC samples. The SQCC patients with high antigen presentation machinery and cytotoxic T cell signature scores are found to have a prolonged overall survival time.

journal_name

Nat Commun

journal_title

Nature communications

authors

Zhang XC,Wang J,Shao GG,Wang Q,Qu X,Wang B,Moy C,Fan Y,Albertyn Z,Huang X,Zhang J,Qiu Y,Platero S,Lorenzi MV,Zudaire E,Yang J,Cheng Y,Xu L,Wu YL

doi

10.1038/s41467-019-09762-1

subject

Has Abstract

pub_date

2019-04-16 00:00:00

pages

1772

issue

1

issn

2041-1723

pii

10.1038/s41467-019-09762-1

journal_volume

10

pub_type

杂志文章

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