CREB controls cortical circuit plasticity and functional recovery after stroke.

abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...

journal_title：Nature communications

authors： Nelson MD,Trojanowski NF,George-Raizen JB,Smith CJ,Yu CC,Fang-Yen C,Raizen DM

更新日期：2013-01-01 00:00:00

abstract：:Ecosystems are composed of complex networks of many species interacting in different ways. While ecologists have long studied food webs of feeding interactions, recent studies increasingly focus on mutualistic networks including plants that exchange food for reproductive services provided by animals such as pollinator...

journal_title：Nature communications

authors： Hale KRS,Valdovinos FS,Martinez ND

更新日期：2020-05-01 00:00:00

abstract：:The 2018 summit and flank eruption of Kīlauea Volcano was one of the largest volcanic events in Hawai'i in 200 years. Data suggest that a backup in the magma plumbing system at the long-lived Pu'u 'Ō'ō eruption site caused widespread pressurization in the volcano, driving magma into the lower flank. The eruption evolv...

journal_title：Nature communications

authors： Patrick MR,Houghton BF,Anderson KR,Poland MP,Montgomery-Brown E,Johanson I,Thelen W,Elias T

更新日期：2020-11-06 00:00:00

abstract：:Large-scale genetic and genomic data are increasingly available and the major bottleneck in their analysis is a lack of sufficiently scalable computational tools. To address this problem in the context of complex traits analysis, we present DISSECT. DISSECT is a new and freely available software that is able to exploi...

journal_title：Nature communications

authors： Canela-Xandri O,Law A,Gray A,Woolliams JA,Tenesa A

更新日期：2015-12-11 00:00:00

abstract：:Selenium cathodes have attracted considerable attention due to high electronic conductivity and volumetric capacity comparable to sulphur cathodes. However, practical development of lithium-selenium batteries has been hindered by the low selenium reaction activity with lithium, high volume changes and rapid capacity f...

journal_title：Nature communications

authors： Tian H,Tian H,Wang S,Chen S,Zhang F,Song L,Liu H,Liu J,Wang G

更新日期：2020-10-06 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the emb...

journal_title：Nature communications

authors： Pineault KM,Song JY,Kozloff KM,Lucas D,Wellik DM

更新日期：2019-07-18 00:00:00

abstract：:Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...

journal_title：Nature communications

authors： Feng X,Hsu SJ,Bhattacharjee A,Wang Y,Diao J,Price CM

更新日期：2018-07-19 00:00:00

abstract：:Percolation in complex networks is a process that mimics network degradation and a tool that reveals peculiarities of the network structure. During the course of percolation, the emergent properties of networks undergo non-trivial transformations, which include a phase transition in the connectivity, and in some speci...

journal_title：Nature communications

authors： Kryven I

更新日期：2019-01-24 00:00:00

abstract：:A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...

journal_title：Nature communications

authors： Tsukada K,Shinki S,Kaneko A,Murakami K,Irie K,Murai M,Miyoshi H,Dan S,Kawaji K,Hayashi H,Kodama EN,Hori A,Salim E,Kuraishi T,Hirata N,Kanda Y,Asai T

更新日期：2020-04-14 00:00:00

abstract：:Large Igneous Provinces (LIPs) are associated with the largest climate perturbations in Earth's history. The North Atlantic Igneous Province (NAIP) and Paleocene-Eocene Thermal Maximum (PETM) constitute an exemplar of this association. As yet we have no means to reconstruct the pacing of LIP greenhouse gas emissions f...

journal_title：Nature communications

authors： Jones SM,Hoggett M,Greene SE,Dunkley Jones T

更新日期：2019-12-05 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00

abstract：:Understanding the resilience of aquatic ectothermic animals to climate warming has been hindered by the absence of experimental systems experiencing warming across relevant timescales (for example, decades). Here, we examine European perch (Perca fluviatilis, L.) from the Biotest enclosure, a unique coastal ecosystem ...

journal_title：Nature communications

authors： Sandblom E,Clark TD,Gräns A,Ekström A,Brijs J,Sundström LF,Odelström A,Adill A,Aho T,Jutfelt F

更新日期：2016-05-17 00:00:00

abstract：:Photovoltaic devices based on metal halide perovskites are rapidly improving in efficiency. Once the Shockley-Queisser limit is reached, charge-carrier extraction will be limited only by radiative bimolecular recombination of electrons with holes. Yet, this fundamental process, and its link with material stoichiometry...

journal_title：Nature communications

authors： Davies CL,Filip MR,Patel JB,Crothers TW,Verdi C,Wright AD,Milot RL,Giustino F,Johnston MB,Herz LM

更新日期：2018-01-18 00:00:00

abstract：:Control over interactions with biomolecules holds the key to applications of graphene in biotechnology. One such application is nanopore sequencing, where a DNA molecule is electrophoretically driven through a graphene nanopore. Here we investigate how interactions of single-stranded DNA and a graphene membrane can be...

journal_title：Nature communications

authors： Shankla M,Aksimentiev A

更新日期：2014-10-09 00:00:00

abstract：:Controlled macrophage differentiation and activation in the initiation and resolution of inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. Here we show a negative feedback mechanism for proinflammatory IFN-γ activation of macrophages driven by macrophage-associated matri...

journal_title：Nature communications

authors： Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM

更新日期：2018-06-20 00:00:00

abstract：:The Dead Sea is one of the most hypersaline habitats on Earth. The fungus Eurotium rubrum (Eurotiomycetes) is among the few species able to survive there. Here we highlight its adaptive strategies, based on genome analysis and transcriptome profiling. The 26.2 Mb genome of E. rubrum shows, for example, gains in gene f...

journal_title：Nature communications

authors： Kis-Papo T,Weig AR,Riley R,Peršoh D,Salamov A,Sun H,Lipzen A,Wasser SP,Rambold G,Grigoriev IV,Nevo E

更新日期：2014-05-09 00:00:00

abstract：:Optical phase change materials (O-PCMs), a unique group of materials featuring exceptional optical property contrast upon a solid-state phase transition, have found widespread adoption in photonic applications such as switches, routers and reconfigurable meta-optics. Current O-PCMs, such as Ge-Sb-Te (GST), exhibit lar...

journal_title：Nature communications

authors： Zhang Y,Chou JB,Li J,Li H,Du Q,Yadav A,Zhou S,Shalaginov MY,Fang Z,Zhong H,Roberts C,Robinson P,Bohlin B,Ríos C,Lin H,Kang M,Gu T,Warner J,Liberman V,Richardson K,Hu J

更新日期：2019-09-30 00:00:00

abstract：:Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show that the tumour sup...

journal_title：Nature communications

authors： Woodford MR,Dunn DM,Blanden AR,Capriotti D,Loiselle D,Prodromou C,Panaretou B,Hughes PF,Smith A,Ackerman W,Haystead TA,Loh SN,Bourboulia D,Schmidt LS,Marston Linehan W,Bratslavsky G,Mollapour M

更新日期：2016-06-29 00:00:00

abstract：:Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) en...

journal_title：Nature communications

authors： Huynh N,Ou Q,Cox P,Lill R,King-Jones K

更新日期：2019-11-29 00:00:00

abstract：:The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...

journal_title：Nature communications

authors： Sajini AA,Choudhury NR,Wagner RE,Bornelöv S,Selmi T,Spanos C,Dietmann S,Rappsilber J,Michlewski G,Frye M

更新日期：2019-06-11 00:00:00

abstract：:Wild boar (Sus scrofa) drastically colonized mainland Eurasia and North Africa, most likely from East Asia during the Plio-Pleistocene (2-1Mya). In recent studies, based on genome-wide information, it was hypothesized that wild boar did not replace the species it encountered, but instead exchanged genetic materials wi...

journal_title：Nature communications

authors： Liu L,Bosse M,Megens HJ,Frantz LAF,Lee YL,Irving-Pease EK,Narayan G,Groenen MAM,Madsen O

更新日期：2019-04-30 00:00:00

abstract：:One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...

journal_title：Nature communications

authors： Valenza JM,Edmonds DA,Hwang T,Roy S

更新日期：2020-04-30 00:00:00

abstract：:Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pa...

journal_title：Nature communications

authors： Fusi C,Materazzi S,Benemei S,Coppi E,Trevisan G,Marone IM,Minocci D,De Logu F,Tuccinardi T,Di Tommaso MR,Susini T,Moneti G,Pieraccini G,Geppetti P,Nassini R

更新日期：2014-12-08 00:00:00

abstract：:The ability to fabricate nanoscale domains of uniform size in two-dimensional materials could potentially enable new applications in nanoelectronics and the development of innovative metamaterials. However, achieving even minimal control over the growth of two-dimensional lateral heterostructures at such extreme dimen...

journal_title：Nature communications

authors： Camilli L,Jørgensen JH,Tersoff J,Stoot AC,Balog R,Cassidy A,Sadowski JT,Bøggild P,Hornekær L

更新日期：2017-06-29 00:00:00

abstract：:Thin films of several microns in thickness are ubiquitously used in packaging, electronics, and acoustic sensors. Here we demonstrate that natural wood can be directly converted into an ultrathin film with a record-small thickness of less than 10 μm through partial delignification followed by densification. Benefiting...

journal_title：Nature communications

authors： Gan W,Chen C,Kim HT,Lin Z,Dai J,Dong Z,Zhou Z,Ping W,He S,Xiao S,Yu M,Hu L

更新日期：2019-11-08 00:00:00

abstract：:Normal epithelial cells are stably connected to each other via the apical junctional complex (AJC). AJCs, however, tend to be disrupted during tumor progression, and this process is implicated in cancer dissemination. Here, using colon carcinoma cells that fail to form AJCs, we investigated molecular defects behind th...

journal_title：Nature communications

authors： Ito S,Okuda S,Abe M,Fujimoto M,Onuki T,Nishimura T,Takeichi M

更新日期：2017-11-28 00:00:00

abstract：:The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker ...

journal_title：Nature communications

authors： Juan-Colás J,Parkin A,Dunn KE,Scullion MG,Krauss TF,Johnson SD

更新日期：2016-09-14 00:00:00

abstract：:Gas-sensing materials are becoming increasingly important in our society, requiring high sensitivity to differentiate similar gases like N2 and O2. For the design of such materials, the driving force of electronic host-guest interaction or host-framework changes during the sorption process has commonly been considered...

journal_title：Nature communications

authors： Kosaka W,Liu Z,Zhang J,Sato Y,Hori A,Matsuda R,Kitagawa S,Miyasaka H

更新日期：2018-12-21 00:00:00

abstract：:Experimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exist or can be generalizable to the large-scale level. Here, we applied dynamic graph theory-based analyses to e...

journal_title：Nature communications

authors： Diez I,Sepulcre J

更新日期：2018-09-24 00:00:00

abstract：:Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, and introduce allele...

journal_title：Nature communications

authors： Bratic A,Kauppila TE,Macao B,Grönke S,Siibak T,Stewart JB,Baggio F,Dols J,Partridge L,Falkenberg M,Wredenberg A,Larsson NG

更新日期：2015-11-10 00:00:00