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Interval breast cancer is associated with other types of tumors.

Abstract：

:Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC of which 1,772 are interval and 13,074 screen-detected. Compared to women with screen-detected cancers, interval breast cancer patients are more likely to have a non-BC tumor before (Odds ratio (OR): 1.43 [1.19-1.70], P = 9.4 x 10-5) and after (OR: 1.28 [1.14-1.44], P = 4.70 x 10-5) breast cancer diagnosis, are more likely to report a family history of non-BC tumors and have a lower genetic risk score based on common variants for non-BC tumors. In conclusion, interval breast cancer is associated with other tumors and common cancer variants are unlikely to be responsible for this association. These findings could have implications for future screening and prevention programs.

journal_name

Nat Commun

journal_title

Nature communications

authors

Grassmann F,He W,Eriksson M,Gabrielson M,Hall P,Czene K

doi

10.1038/s41467-019-12652-1

subject

Has Abstract

pub_date

2019-10-22 00:00:00

pages

4648

issue

1

issn

2041-1723

pii

10.1038/s41467-019-12652-1

journal_volume

10

pub_type

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