Abstract:
:Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (TFH) cells in vitro and in vivo, thereby exerting immune regulatory and tolerance-inducing properties. Alcohol-exposed mice have reduced Bcl6 and PD-1 expression as well as IL-21 production by TFH cells, preventing proper spatial organization of TFH cells to form TFH:B cell conjugates in germinal centers. This effect is associated with impaired autoantibody formation, and mitigates experimental autoimmune arthritis. By contrast, T cell independent immune responses and passive models of arthritis are not affected by alcohol exposure. These data clarify the immune regulatory and tolerance-inducing effect of alcohol consumption.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz Sdoi
10.1038/s41467-020-15855-zsubject
Has Abstractpub_date
2020-04-24 00:00:00pages
1998issue
1issn
2041-1723pii
10.1038/s41467-020-15855-zjournal_volume
11pub_type
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