Addendum: Precise tuning of gene expression levels in mammalian cells.

abstract：:MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...

journal_title：Nature communications

authors： Ruelens P,de Maagd RA,Proost S,Theißen G,Geuten K,Kaufmann K

更新日期：2013-01-01 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:Recent studies suggest that gut microbiomes of urban-industrialized societies are different from those of traditional peoples. Here we examine the relationship between lifeways and gut microbiota through taxonomic and functional potential characterization of faecal samples from hunter-gatherer and traditional agricult...

journal_title：Nature communications

authors： Obregon-Tito AJ,Tito RY,Metcalf J,Sankaranarayanan K,Clemente JC,Ursell LK,Zech Xu Z,Van Treuren W,Knight R,Gaffney PM,Spicer P,Lawson P,Marin-Reyes L,Trujillo-Villarroel O,Foster M,Guija-Poma E,Troncoso-Corzo L,Warinne

更新日期：2015-03-25 00:00:00

abstract：:Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is largely unknown. We ...

journal_title：Nature communications

authors： Nie H,Ju H,Fan J,Shi X,Cheng Y,Cang X,Zheng Z,Duan X,Yi W

更新日期：2020-01-07 00:00:00

abstract：:CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to m...

journal_title：Nature communications

authors： Zaric M,Becker PD,Hervouet C,Kalcheva P,Doszpoly A,Blattman N,A O' Neill L,Yus BI,Cocita C,Kwon SY,Baker AH,Lord GM,Klavinskis LS

更新日期：2019-05-17 00:00:00

abstract：:The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein's amino acids ('intra-gene epistasis'). Our limited understanding of such epistasis hinders the correct prediction of the funct...

journal_title：Nature communications

authors： Zurek PJ,Knyphausen P,Neufeld K,Pushpanath A,Hollfelder F

更新日期：2020-11-26 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes and accelerates pep...

journal_title：Nature communications

authors： Katoh T,Wohlgemuth I,Nagano M,Rodnina MV,Suga H

更新日期：2016-05-24 00:00:00

abstract：:Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical sign...

journal_title：Nature communications

authors： Castilla S,Vangelidis I,Pusapati VV,Goldstein J,Autore M,Slipchenko T,Rajendran K,Kim S,Watanabe K,Taniguchi T,Martín-Moreno L,Englund D,Tielrooij KJ,Hillenbrand R,Lidorikis E,Koppens FHL

更新日期：2020-09-25 00:00:00

abstract：:Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as t...

journal_title：Nature communications

authors： Mandric I,Rotman J,Yang HT,Strauli N,Montoya DJ,Van Der Wey W,Ronas JR,Statz B,Yao D,Petrova V,Zelikovsky A,Spreafico R,Shifman S,Zaitlen N,Rossetti M,Ansel KM,Eskin E,Mangul S

更新日期：2020-06-19 00:00:00

abstract：:The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopen...

journal_title：Nature communications

authors： Migliavacca E,Tay SKH,Patel HP,Sonntag T,Civiletto G,McFarlane C,Forrester T,Barton SJ,Leow MK,Antoun E,Charpagne A,Seng Chong Y,Descombes P,Feng L,Francis-Emmanuel P,Garratt ES,Giner MP,Green CO,Karaz S,Kothandaram

更新日期：2019-12-20 00:00:00

abstract：:Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of ...

journal_title：Nature communications

authors： Chen Y,Siegel F,Kipschull S,Haas B,Fröhlich H,Meister G,Pfeifer A

更新日期：2013-01-01 00:00:00

abstract：:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

journal_title：Nature communications

authors： Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

更新日期：2020-08-10 00:00:00

abstract：:CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing u...

journal_title：Nature communications

authors： Cullot G,Boutin J,Toutain J,Prat F,Pennamen P,Rooryck C,Teichmann M,Rousseau E,Lamrissi-Garcia I,Guyonnet-Duperat V,Bibeyran A,Lalanne M,Prouzet-Mauléon V,Turcq B,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,

更新日期：2019-03-08 00:00:00

abstract：:Sedimentary rocks are the archives of environmental conditions and ancient planetary surface processes that led to their formation. Reconstructions of Earth's past surface behaviour from the physical sedimentary record remain controversial, however, in part because we lack a quantitative framework to deconvolve intern...

journal_title：Nature communications

authors： Ganti V,Lamb MP,McElroy B

更新日期：2014-02-28 00:00:00

abstract：:RNA has emerged as a promising material for nanostructure and microstructure engineering. Although rare, some macroscopic RNA structures have also been constructed using lipid or polymer materials. Here, we report the first example of an enzymatically generated RNA membrane. This robust and free-standing RNA membrane ...

journal_title：Nature communications

authors： Han D,Park Y,Kim H,Lee JB

更新日期：2014-07-04 00:00:00

abstract：:In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunne...

journal_title：Nature communications

authors： Ma C,Xiao Z,Zhang H,Liang L,Huang J,Lu W,Sumpter BG,Hong K,Bernholc J,Li AP

更新日期：2017-03-13 00:00:00

abstract：:Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...

journal_title：Nature communications

authors： Nagata K,Takahashi M,Matsuba Y,Okuyama-Uchimura F,Sato K,Hashimoto S,Saito T,Saido TC

更新日期：2018-05-04 00:00:00

abstract：:Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the eff...

journal_title：Nature communications

authors： Kruskal PB,Li L,MacLean JN

更新日期：2013-01-01 00:00:00

abstract：:Graphene flakes with giant shape anisotropy are extensively used to establish connectedness electrical percolation in various heterogeneous systems. However, the percolation behaviour of graphene flakes has been recently predicted to be far more complicated than generally anticipated on the basis of excluded volume ar...

journal_title：Nature communications

authors： Yuan J,Luna A,Neri W,Zakri C,Schilling T,Colin A,Poulin P

更新日期：2015-11-16 00:00:00

abstract：:Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and...

journal_title：Nature communications

authors： Gray DL,Allen JA,Mente S,O'Connor RE,DeMarco GJ,Efremov I,Tierney P,Volfson D,Davoren J,Guilmette E,Salafia M,Kozak R,Ehlers MD

更新日期：2018-02-14 00:00:00

abstract：:Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissu...

journal_title：Nature communications

authors： Chen F,Ma K,Madajewski B,Zhuang L,Zhang L,Rickert K,Marelli M,Yoo B,Turker MZ,Overholtzer M,Quinn TP,Gonen M,Zanzonico P,Tuesca A,Bowen MA,Norton L,Subramony JA,Wiesner U,Bradbury MS

更新日期：2018-10-08 00:00:00

abstract：:The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...

journal_title：Nature communications

authors： Di Renzo M,Urzay J

更新日期：2018-05-21 00:00:00

abstract：:The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...

journal_title：Nature communications

authors： Kiga K,Tan XE,Ibarra-Chávez R,Watanabe S,Aiba Y,Sato'o Y,Li FY,Sasahara T,Cui B,Kawauchi M,Boonsiri T,Thitiananpakorn K,Taki Y,Azam AH,Suzuki M,Penadés JR,Cui L

更新日期：2020-06-10 00:00:00

abstract：:Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections. Here we report that treatment with the oral mineralocorticoid receptor (MR) antagonist spironolactone reduces...

journal_title：Nature communications

authors： Zhao M,Mantel I,Gelize E,Li X,Xie X,Arboleda A,Seminel M,Levy-Boukris R,Dernigoghossian M,Prunotto A,Andrieu-Soler C,Rivolta C,Canonica J,Naud MC,Lechner S,Farman N,Bravo-Osuna I,Herrero-Vanrell R,Jaisser F,Behar-Co

更新日期：2019-01-21 00:00:00

abstract：:Clustering of arc volcanoes in subduction zones indicates along-arc variation in the physical condition of the underlying mantle where majority of arc magmas are generated. The sub-arc mantle is brought in from the back-arc largely by slab-driven mantle wedge flow. Dynamic processes in the back-arc, such as small-scal...

journal_title：Nature communications

authors： Lee C,Wada I

更新日期：2017-06-29 00:00:00

abstract：:Recent studies show that the D'' layer, just above the Earth's core-mantle boundary, is composed of MgSiO3 post-perovskite and has significant lateral inhomogeneity. Here we consider the D'' diversity as related to the single-crystal elasticity of the post-perovskite phase. We measure the single-crystal elasticity of ...

journal_title：Nature communications

authors： Yoneda A,Fukui H,Xu F,Nakatsuka A,Yoshiasa A,Seto Y,Ono K,Tsutsui S,Uchiyama H,Baron AQ

更新日期：2014-03-27 00:00:00

abstract：:Extremely metal-poor galaxies with metallicity below 10% of the solar value in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. In spite of the ongoing formation of stars in these galaxies, the presence of molecular gas (which is...

journal_title：Nature communications

authors： Shi Y,Wang J,Zhang ZY,Gao Y,Hao CN,Xia XY,Gu Q

更新日期：2016-12-09 00:00:00

abstract：:Remarkable breakthroughs have established the functionality of graphene and carbon nanotube transistors as replacements to silicon in conventional computing structures, and numerous spintronic logic gates have been presented. However, an efficient cascaded logic structure that exploits electron spin has not yet been d...

journal_title：Nature communications

authors： Friedman JS,Girdhar A,Gelfand RM,Memik G,Mohseni H,Taflove A,Wessels BW,Leburton JP,Sahakian AV

更新日期：2017-06-05 00:00:00

abstract：:Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this challenge. Various regulators are known to interact with different coiled coil regions of NEMO, but the topologic...

journal_title：Nature communications

authors： Sadek J,Wuo MG,Rooklin D,Hauenstein A,Hong SH,Gautam A,Wu H,Zhang Y,Cesarman E,Arora PS

更新日期：2020-04-14 00:00:00