Abstract:
:Extremely metal-poor galaxies with metallicity below 10% of the solar value in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. In spite of the ongoing formation of stars in these galaxies, the presence of molecular gas (which is known to provide the material reservoir for star formation in galaxies such as our Milky Way) remains unclear. Here we report the detection of carbon monoxide (CO), the primary tracer of molecular gas, in a galaxy with 7% solar metallicity, with additional detections in two galaxies at higher metallicities. Such detections offer direct evidence for the existence of molecular gas in these galaxies that contain few metals. Using archived infrared data, it is shown that the molecular gas mass per CO luminosity at extremely low metallicity is approximately one-thousand times the Milky Way value.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Shi Y,Wang J,Zhang ZY,Gao Y,Hao CN,Xia XY,Gu Qdoi
10.1038/ncomms13789subject
Has Abstractpub_date
2016-12-09 00:00:00pages
13789issn
2041-1723pii
ncomms13789journal_volume
7pub_type
杂志文章abstract::Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13838-3
更新日期:2020-01-07 00:00:00
abstract::Cyanobacteria are model organisms for photosynthesis and are attractive for biotechnology applications. To aid investigation of genotype-phenotype relationships in cyanobacteria, we develop an inducible CRISPRi gene repression library in Synechocystis sp. PCC 6803, where we aim to target all genes for repression. We t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15491-7
更新日期:2020-04-03 00:00:00
abstract::Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04049-3
更新日期:2018-04-24 00:00:00
abstract::Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale targeted proteomics, that the metabolism both carbon and nitrogen is altered during the malignant progression of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15136-9
更新日期:2020-03-17 00:00:00
abstract::Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9362
更新日期:2015-10-16 00:00:00
abstract::ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction with aurora kinase A (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05694-4
更新日期:2018-08-10 00:00:00
abstract::The plausibility of any model in science comes from the extent of its interconnections to other models that are grounded in different premises and reasoning. Focusing research on paradoxes in those models, logic whereby they appear to generate unacceptable conclusions from seemingly indisputable premises, helps find t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07274-y
更新日期:2018-12-12 00:00:00
abstract::Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-16859-5
更新日期:2020-06-16 00:00:00
abstract::Nonsense-mediated decay (NMD) eliminates transcripts with premature termination codons. Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. Here we develop an algorithm to predict NMD and apply...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15943
更新日期:2017-06-26 00:00:00
abstract::The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02642-6
更新日期:2018-01-08 00:00:00
abstract::High strength and high ductility are often mutually exclusive properties for structural metallic materials. This is particularly important for aluminum (Al)-based alloys which are widely commercially employed. Here, we introduce a hierarchical nanostructured Al alloy with a structure of Al nanograins surrounded by nan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13087-4
更新日期:2019-11-08 00:00:00
abstract::Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9009
更新日期:2015-08-18 00:00:00
abstract::Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14200-3
更新日期:2020-01-23 00:00:00
abstract::Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14229
更新日期:2017-02-06 00:00:00
abstract::Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04910-5
更新日期:2018-07-17 00:00:00
abstract::Graphene has an extremely high in-plane strength yet considerable out-of-plane softness. High crystalline order of graphene assemblies is desired to utilize their in-plane properties, however, challenged by the easy formation of chaotic wrinkles for the intrinsic softness. Here, we find an intercalation modulated plas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16494-0
更新日期:2020-05-27 00:00:00
abstract::The gravitational collapse of eruption columns generates ground-hugging pyroclastic density currents (PDCs) with highly variable temperatures, high enough to be a threat for communities surrounding volcanoes. The reasons for such great temperature variability are debated in terms of eruptive versus transport and empla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10337-3
更新日期:2019-06-06 00:00:00
abstract::Measuring the pace at which speciation and extinction occur is fundamental to understanding the origin and evolution of biodiversity. Both the fossil record and molecular phylogenies of living species can provide independent estimates of speciation and extinction rates, but often produce strikingly divergent results. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07622-y
更新日期:2018-12-07 00:00:00
abstract::Phospholipids are elemental building-block molecules for biological membranes. Biosynthesis of phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthetase (Cds) is an integral membrane enzym...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5244
更新日期:2014-06-27 00:00:00
abstract::The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enrich...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6890
更新日期:2015-01-19 00:00:00
abstract::Hyperconnected network architectures can endow nanomaterials with remarkable mechanical properties that are fundamentally controlled by designing connectivity into the intrinsic molecular structure. For hybrid organic-inorganic nanomaterials, here we show that by using 1,3,5 silyl benzene precursors, the connectivity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01305-w
更新日期:2017-10-18 00:00:00
abstract::Van Allen radiation belts are typically two zones of energetic particles encircling the Earth separated by the slot region. How the outer radiation belt electrons are accelerated to relativistic energies remains an unanswered question. Recent studies have presented compelling evidence for the local acceleration by ver...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10096
更新日期:2015-12-22 00:00:00
abstract::In two-dimensional (2D) lattices, the electronic levels are unevenly spaced, and the density of states (DOS) displays a logarithmic divergence known as the Van Hove singularity (VHS). This is the case in particular for the layered cuprate superconductors. The scanning tunnelling microscope (STM) probes the DOS, and is...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1229
更新日期:2011-01-01 00:00:00
abstract::Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology ar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6438
更新日期:2014-11-11 00:00:00
abstract::River capture is a dramatic natural process of internal competition through which mountainous landscapes evolve and respond to perturbations in tectonics and climate. River capture may occur when one river network grows at the expense of another, resulting in a victor that steals the neighboring headwaters. While rive...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06238-6
更新日期:2018-09-14 00:00:00
abstract::Among calcareous nannofossils, important primary producers in Jurassic and Cretaceous oceans, nannoconids were carbonate rock-forming organisms. During the late Barremian and early Aptian (~126 to 122 million years ago), nannoconids went through a crisis culminating during the Oceanic Anoxic Event 1a. Here we present ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2698
更新日期:2013-01-01 00:00:00
abstract::Lipids and amphiphilic block copolymers spontaneously self-assemble in water to form a plethora of micelles and vesicles. They are typically fluidic in nature and often mechanically weak for applications such as drug delivery and gene therapeutics. Mechanical properties of polymeric materials could be improved by form...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10599
更新日期:2016-02-03 00:00:00
abstract::Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12738
更新日期:2016-09-27 00:00:00
abstract::Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-018-04109-8
更新日期:2018-06-11 00:00:00
abstract::Haploinsufficiency of the SLC2A1 gene and paucity of its translated product, the glucose transporter-1 (Glut1) protein, disrupt brain function and cause the neurodevelopmental disorder, Glut1 deficiency syndrome (Glut1 DS). There is little to suggest how reduced Glut1 causes cognitive dysfunction and no optimal treatm...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14152
更新日期:2017-01-20 00:00:00