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Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons.

Abstract：

:Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optogenetic activation of these neurons after nerve injury evokes marked nociceptive behavior. Using a phototherapeutic approach based upon BDNF, the ligand for TrkB, we perform molecule-guided laser ablation of these neurons and achieve long-term retraction of TrkB-positive neurons from the skin and pronounced reversal of mechanical allodynia across multiple types of neuropathic pain. Thus we identify the peripheral neurons which transmit pain from light touch and uncover a novel pharmacological strategy for its treatment.

journal_name

Nat Commun

journal_title

Nature communications

authors

Dhandapani R,Arokiaraj CM,Taberner FJ,Pacifico P,Raja S,Nocchi L,Portulano C,Franciosa F,Maffei M,Hussain AF,de Castro Reis F,Reymond L,Perlas E,Garcovich S,Barth S,Johnsson K,Lechner SG,Heppenstall PA

doi

10.1038/s41467-018-04049-3

subject

Has Abstract

pub_date

2018-04-24 00:00:00

pages

1640

issue

1

issn

2041-1723

pii

10.1038/s41467-018-04049-3

journal_volume

9

pub_type

杂志文章

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