Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.

abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

journal_title：Nature communications

authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

更新日期：2021-01-04 00:00:00

abstract：:The breast cancer susceptibility gene BRCA1 is well known for its function in double-strand break (DSB) DNA repair. While BRCA1 is also implicated in transcriptional regulation, the physiological significance remains unclear. COBRA1 (also known as NELF-B) is a BRCA1-binding protein that regulates RNA polymerase II (RN...

journal_title：Nature communications

authors： Nair SJ,Zhang X,Chiang HC,Jahid MJ,Wang Y,Garza P,April C,Salathia N,Banerjee T,Alenazi FS,Ruan J,Fan JB,Parvin JD,Jin VX,Hu Y,Li R

更新日期：2016-03-04 00:00:00

abstract：:Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...

journal_title：Nature communications

authors： Smith SE,Chen X,Brier LM,Bumstead JR,Rensing NR,Ringel AE,Shin H,Oldenborg A,Crowley JR,Bice AR,Dikranian K,Ippolito JE,Haigis MC,Papouin T,Zhao G,Wong M,Culver JP,Bonni A

更新日期：2020-12-02 00:00:00

abstract：:The mesopelagic (200-1000 m) separates the productive upper ocean from the deep ocean, yet little is known of its long-term dynamics despite recent research that suggests fishes of this zone likely dominate global fish biomass and contribute to the downward flux of carbon. Here we show that mesopelagic fishes dominate...

journal_title：Nature communications

authors： Jones WA,Checkley DM Jr

更新日期：2019-10-08 00:00:00

abstract：:In conventional computers, wiring between transistors is required to enable the execution of Boolean logic functions. This has resulted in processors in which billions of transistors are physically interconnected, which limits integration densities, gives rise to huge power consumption and restricts processing speeds....

journal_title：Nature communications

authors： Mahboob I,Flurin E,Nishiguchi K,Fujiwara A,Yamaguchi H

更新日期：2011-02-15 00:00:00

abstract：:Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...

journal_title：Nature communications

authors： Wang H,Zhang X,Yan D,Somsen C,Eggeler G

更新日期：2018-10-01 00:00:00

abstract：:Gene-targeted animal models that are generated by injecting Cas9 and sgRNAs into zygotes are often accompanied by undesired double-strand break (DSB)-induced byproducts and random biallelic targeting due to uncontrollable Cas9 targeting activity. Here, we establish a parental allele-specific gene-targeting (Past-CRISP...

journal_title：Nature communications

authors： Li Y,Weng Y,Bai D,Jia Y,Liu Y,Zhang Y,Kou X,Zhao Y,Ruan J,Chen J,Yin J,Wang H,Teng X,Wang Z,Liu W,Gao S

更新日期：2020-09-14 00:00:00

abstract：:Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles...

journal_title：Nature communications

authors： Xu X,Huang S,Zhang B,Huang F,Chi W,Fu J,Wang G,Li S,Jiang Q,Zhang C

更新日期：2017-04-27 00:00:00

abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...

journal_title：Nature communications

authors： Dorrity MW,Saunders LM,Queitsch C,Fields S,Trapnell C

更新日期：2020-03-24 00:00:00

abstract：:Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogr...

journal_title：Nature communications

authors： Brami-Cherrier K,Lewis RG,Cervantes M,Liu Y,Tognini P,Baldi P,Sassone-Corsi P,Borrelli E

更新日期：2020-09-07 00:00:00

abstract：:Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation wou...

journal_title：Nature communications

authors： Kim TW,Jun S,Ha Y,Yadav RK,Kumar A,Yoo CY,Oh I,Lim HK,Shin JW,Ryoo R,Kim H,Kim J,Baeg JO,Ihee H

更新日期：2019-04-23 00:00:00

abstract：:Photothermal heating represents a major constraint that limits the performance of many nanoscale optoelectronic and optomechanical devices including nanolasers, quantum optomechanical resonators, and integrated photonic circuits. Here, we demonstrate the direct laser refrigeration of a semiconductor optomechanical res...

journal_title：Nature communications

authors： Pant A,Xia X,Davis EJ,Pauzauskie PJ

更新日期：2020-06-23 00:00:00

abstract：:The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rin...

journal_title：Nature communications

authors： Hu J,Worrall LJ,Hong C,Vuckovic M,Atkinson CE,Caveney N,Yu Z,Strynadka NCJ

更新日期：2018-09-21 00:00:00

abstract：:Lithium metal batteries have been considerably limited by the problems of uncontrolled dendritic lithium formation and the highly reactive nature of lithium with electrolytes. Herein, we have developed functional porous bilayer composite separators by simply blade-coating polyacrylamide-grafted graphene oxide molecula...

journal_title：Nature communications

authors： Li C,Liu S,Shi C,Liang G,Lu Z,Fu R,Wu D

更新日期：2019-03-25 00:00:00

abstract：:Crystallization by particle attachment is impacting our understanding of natural mineralization processes and holds promise for novel materials design. When particles assemble in crystallographic alignment, expulsion of the intervening solvent and particle coalescence are enabled by near-perfect co-alignment via inter...

journal_title：Nature communications

authors： Zhang X,Shen Z,Liu J,Kerisit SN,Bowden ME,Sushko ML,De Yoreo JJ,Rosso KM

更新日期：2017-10-10 00:00:00

abstract：:Foxp3+ regulatory T (Treg) cells are essential for maintaining peripheral tolerance and preventing autoimmunity. While genetic factors may predispose for autoimmunity, additional environmental triggers, such as viral infections, are usually required to initiate the onset of disease. Here, we show that viral infection ...

journal_title：Nature communications

authors： Schorer M,Lambert K,Rakebrandt N,Rost F,Kao KC,Yermanos A,Spörri R,Oderbolz J,Raeber ME,Keller CW,Lünemann JD,Rogler G,Boyman O,Oxenius A,Joller N

更新日期：2020-03-23 00:00:00

abstract：:Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...

journal_title：Nature communications

authors： Ding D,Liu J,Midic U,Wu Y,Dong K,Melnick A,Latham KE,Chen C

更新日期：2018-01-09 00:00:00

abstract：:Incorporating oxophilic metals into noble metal-based catalysts represents an emerging strategy to improve the catalytic performance of electrocatalysts in fuel cells. However, effects of the distance between the noble metal and oxophilic metal active sites on the catalytic performance have rarely been investigated. H...

journal_title：Nature communications

authors： Chen L,Lu L,Zhu H,Chen Y,Huang Y,Li Y,Wang L

更新日期：2017-01-10 00:00:00

abstract：:Oriented assemblies of functional nanoparticles, with the aid of external physical and chemical driving forces, have been prepared on two-dimensional solid substrates. It is challengeable, however, to achieve three-dimensional assembly directly in solution, owing to thermal fluctuations and free diffusion. Here we des...

journal_title：Nature communications

authors： Kim K,Han HS,Choi I,Lee C,Hong S,Suh SH,Lee LP,Kang T

更新日期：2013-01-01 00:00:00

abstract：:Single-crystal cathode materials for lithium-ion batteries have attracted increasing interest in providing greater capacity retention than their polycrystalline counterparts. However, after being cycled at high voltages, these single-crystal materials exhibit severe structural instability and capacity fade. Understand...

journal_title：Nature communications

authors： Zhang F,Lou S,Li S,Yu Z,Liu Q,Dai A,Cao C,Toney MF,Ge M,Xiao X,Lee WK,Yao Y,Deng J,Liu T,Tang Y,Yin G,Lu J,Su D,Wang J

更新日期：2020-06-16 00:00:00

abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

journal_title：Nature communications

authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

更新日期：2018-08-17 00:00:00

abstract：:SMC (structural maintenance of chromosomes) family members play essential roles in chromosome condensation, sister chromatid cohesion and DNA repair. It remains unclear how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with DNA. Here we used single-molecule fluorescence mi...

journal_title：Nature communications

authors： Kim H,Loparo JJ

更新日期：2016-01-04 00:00:00

abstract：:Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost c...

journal_title：Nature communications

authors： Robinson A,Alvarez-Solas J,Calov R,Ganopolski A,Montoya M

更新日期：2017-07-06 00:00:00

abstract：:Owing to the advantages of integration and being magnet-free and light-weight, the switched-capacitor-convertor plays an increasing role compared to traditional transformer in some specific power supply systems. However, the high output impedance and switching loss largely reduces its power efficiency, due to imperfec...

journal_title：Nature communications

authors： Liu W,Wang Z,Wang G,Zeng Q,He W,Liu L,Wang X,Xi Y,Guo H,Hu C,Wang ZL

更新日期：2020-04-20 00:00:00

abstract：:Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum k...

journal_title：Nature communications

authors： Gehring T,Händchen V,Duhme J,Furrer F,Franz T,Pacher C,Werner RF,Schnabel R

更新日期：2015-10-30 00:00:00

abstract：:Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcription factors, IKZF1 (or IKZF3) and SALL4, respectively. Here, we report the structural bases for the SA...

journal_title：Nature communications

authors： Furihata H,Yamanaka S,Honda T,Miyauchi Y,Asano A,Shibata N,Tanokura M,Sawasaki T,Miyakawa T

更新日期：2020-09-14 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:Crystalline phase transitions caused by external stimuli have been used to detect physical changes in the solid-state properties. This study presents the mechanical switching of crystals of ferrocene-containing rotaxane controlled by focused laser light. The expansion and contraction of the crystals can be driven by t...

journal_title：Nature communications

authors： Chen KJ,Tsai YC,Suzaki Y,Osakada K,Miura A,Horie M

更新日期：2016-11-03 00:00:00

abstract：:Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...

journal_title：Nature communications

authors： Qi Y,Naumov PG,Ali MN,Rajamathi CR,Schnelle W,Barkalov O,Hanfland M,Wu SC,Shekhar C,Sun Y,Süß V,Schmidt M,Schwarz U,Pippel E,Werner P,Hillebrand R,Förster T,Kampert E,Parkin S,Cava RJ,Felser C,Yan B,Medvedev S

更新日期：2016-03-14 00:00:00

abstract：:Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-05-09 00:00:00