Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein.

abstract：:Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...

journal_title：Nature communications

authors： Scherübl Z,Fülöp G,Moca CP,Gramich J,Baumgartner A,Makk P,Elalaily T,Schönenberger C,Nygård J,Zaránd G,Csonka S

更新日期：2020-04-14 00:00:00

abstract：:We trained and validated risk prediction models for the three major types of skin cancer- basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma-on a cross-sectional and longitudinal dataset of 210,000 consented research participants who responded to an online survey covering personal and family histo...

journal_title：Nature communications

authors： Fontanillas P,Alipanahi B,Furlotte NA,Johnson M,Wilson CH,23andMe Research Team.,Pitts SJ,Gentleman R,Auton A

更新日期：2021-01-08 00:00:00

abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

journal_title：Nature communications

authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

更新日期：2018-08-17 00:00:00

abstract：:Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation conditions. We found that the carbon nanotubes exhibit efficient near-in...

journal_title：Nature communications

authors： Akizuki N,Aota S,Mouri S,Matsuda K,Miyauchi Y

更新日期：2015-11-16 00:00:00

abstract：:Semiconductur nano- and micropillars represent a promising platform for hybrid nanodevices. Their ability to couple to a broad variety of nanomechanical, acoustic, charge, spin, excitonic, polaritonic, or electromagnetic excitations is utilized in fields as diverse as force sensing or optoelectronics. In order to full...

journal_title：Nature communications

authors： Doster J,Hoenl S,Lorenz H,Paulitschke P,Weig EM

更新日期：2019-11-20 00:00:00

abstract：:The NLRP3 inflammasome is the most characterized inflammasome activated by cellular infection or stress, which is responsible for the maturation of proinflammatory cytokines IL-1β and IL-18. The precise molecular mechanism for negative regulation of NLRP3 inflammasome activation needs to be further defined. Here we id...

journal_title：Nature communications

authors： Jin J,Yu Q,Han C,Hu X,Xu S,Wang Q,Wang J,Li N,Cao X

更新日期：2013-01-01 00:00:00

abstract：:The equilibrium volume of a thermoresponsive polymer gel changes dramatically across a temperature due to the coil-globule transitions of the polymers. When cofacially oriented nanosheets are embedded in such a gel, the composite gel deforms at the temperature, without changing the volume, and the response time is con...

journal_title：Nature communications

authors： Yamamoto T,Masubuchi Y,Doi M

更新日期：2018-05-25 00:00:00

abstract：:The miR-200 family members have been implicated in stress responses and ovarian tumorigenesis. Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested. PTPN6 and miR-200c/141 are transcriptionally co-regul...

journal_title：Nature communications

authors： Batista L,Bourachot B,Mateescu B,Reyal F,Mechta-Grigoriou F

更新日期：2016-01-04 00:00:00

abstract：:Polycyclic aromatic hydrocarbons as well as other organic molecules appear among the most abundant observed species in interstellar space and are key molecules to understanding the prebiotic roots of life. However, their existence and abundance in space remain a puzzle. Here we present a new top-down route to form pol...

journal_title：Nature communications

authors： Merino P,Švec M,Martinez JI,Jelinek P,Lacovig P,Dalmiglio M,Lizzit S,Soukiassian P,Cernicharo J,Martin-Gago JA

更新日期：2014-01-01 00:00:00

abstract：:Oxygen defect control has long been considered an important route to functionalizing complex oxide films. However, the nature of oxygen defects in thin films is often not investigated beyond basic redox chemistry. One of the model examples for oxygen-defect studies is the layered Ruddlesden-Popper phase La2-xSr x CuO4...

journal_title：Nature communications

authors： Meyer TL,Jacobs R,Lee D,Jiang L,Freeland JW,Sohn C,Egami T,Morgan D,Lee HN

更新日期：2018-01-08 00:00:00

abstract：:Monitoring of protein oligomerization has benefited greatly from Förster Resonance Energy Transfer (FRET) measurements. Although donors and acceptors are typically fluorescent molecules with different spectra, homo-FRET can occur between fluorescent molecules of the same type if the emission spectrum overlaps with the...

journal_title：Nature communications

authors： Ojha N,Rainey KH,Patterson GH

更新日期：2020-01-07 00:00:00

abstract：:Textural properties provide information on the ingestibility, digestibility and state of ripeness or decay of sources of nutrition. Compared with our understanding of the chemosensory assessment of food, little is known about the mechanisms of texture detection. Here we show that Drosophila melanogaster can discrimina...

journal_title：Nature communications

authors： Sánchez-Alcañiz JA,Zappia G,Marion-Poll F,Benton R

更新日期：2017-01-27 00:00:00

abstract：:Compared with noble metals, semiconductors with surface plasmon resonance effect are another type of SERS substrate materials. The main obstacles so far are that the semiconducting materials are often unstable and easy to be further oxidized or decomposed by laser irradiating or contacting with corrosive substances. H...

journal_title：Nature communications

authors： Zhang Q,Li X,Ma Q,Zhang Q,Bai H,Yi W,Liu J,Han J,Xi G

更新日期：2017-04-24 00:00:00

abstract：:Mechanical injury to connective tissue causes changes in collagen structure and material behaviour, but the role and mechanisms of molecular damage have not been established. In the case of mechanical subfailure damage, no apparent macroscale damage can be detected, yet this damage initiates and potentiates in patholo...

journal_title：Nature communications

authors： Zitnay JL,Li Y,Qin Z,San BH,Depalle B,Reese SP,Buehler MJ,Yu SM,Weiss JA

更新日期：2017-03-22 00:00:00

abstract：:Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...

journal_title：Nature communications

authors： Zhang X,Bishawi M,Zhang G,Prasad V,Salmon E,Breithaupt JJ,Zhang Q,Truskey GA

更新日期：2020-10-27 00:00:00

abstract：:Electric fields can transform materials with respect to their structure and properties, enabling various applications ranging from batteries to spintronics. Recently electrolytic gating, which can generate large electric fields and voltage-driven ion transfer, has been identified as a powerful means to achieve electri...

journal_title：Nature communications

authors： Yi D,Wang Y,van ʼt Erve OMJ,Xu L,Yuan H,Veit MJ,Balakrishnan PP,Choi Y,N'Diaye AT,Shafer P,Arenholz E,Grutter A,Xu H,Yu P,Jonker BT,Suzuki Y

更新日期：2020-02-14 00:00:00

abstract：:The interaction of lipids and proteins plays an important role in plasma membrane bioactivity, and much can be learned from their diffusion characteristics. Here we present the combination of super-resolution STED microscopy with scanning fluorescence correlation spectroscopy (scanning STED-FCS, sSTED-FCS) to characte...

journal_title：Nature communications

authors： Honigmann A,Mueller V,Ta H,Schoenle A,Sezgin E,Hell SW,Eggeling C

更新日期：2014-11-20 00:00:00

abstract：:Plasmonics on metal-dielectric interfaces was widely seen as the main route for miniaturization of components and interconnect of photonic circuits. However recently, ultra-confined surface phonon-polaritonics in high-index chalcogenide films of nanometric thickness has emerged as an important alternative to plasmonic...

journal_title：Nature communications

authors： Dubrovkin AM,Qiang B,Salim T,Nam D,Zheludev NI,Wang QJ

更新日期：2020-04-20 00:00:00

abstract：:Expansion of Hevea brasiliensis rubber plantations is a resurgent driver of deforestation, carbon emissions, and biodiversity loss in Southeast Asia. Southeast Asian rubber extent is massive, equivalent to 67% of oil palm, with rapid further expansion predicted. Results-based carbon finance could dis-incentivise fores...

journal_title：Nature communications

authors： Warren-Thomas EM,Edwards DP,Bebber DP,Chhang P,Diment AN,Evans TD,Lambrick FH,Maxwell JF,Nut M,O'Kelly HJ,Theilade I,Dolman PM

更新日期：2018-03-02 00:00:00

abstract：:Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identify the protein targets of a compound and also detect the interaction s...

journal_title：Nature communications

authors： Piazza I,Beaton N,Bruderer R,Knobloch T,Barbisan C,Chandat L,Sudau A,Siepe I,Rinner O,de Souza N,Picotti P,Reiter L

更新日期：2020-08-21 00:00:00

abstract：:LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth ...

journal_title：Nature communications

authors： Ding LW,Sun QY,Edwards JJ,Fernández LT,Ran XB,Zhou SQ,Scolyer RA,Wilmott JS,Thompson JF,Doan N,Said JW,Venkatachalam N,Xiao JF,Loh XY,Pein M,Xu L,Mullins DW,Yang H,Lin DC,Koeffler HP

更新日期：2019-05-20 00:00:00

abstract：:A collective order of spin and charge degrees of freedom into stripes has been predicted to be a possible ground state of hole-doped CuO(2) planes, which are the building blocks of high-temperature superconductors. In fact, stripe-like spin and charge order has been observed in various layered cuprate systems. For the...

journal_title：Nature communications

authors： Wu HH,Buchholz M,Trabant C,Chang CF,Komarek AC,Heigl F,Zimmermann MV,Cwik M,Nakamura F,Braden M,Schüßler-Langeheine C

更新日期：2012-01-01 00:00:00

abstract：:Radiofrequency switches are critical components in wireless communication systems and consumer electronics. Emerging devices include switches based on microelectromechanical systems and phase-change materials. However, these devices suffer from disadvantages such as large physical dimensions and high actuation voltage...

journal_title：Nature communications

authors： Pi S,Ghadiri-Sadrabadi M,Bardin JC,Xia Q

更新日期：2015-06-25 00:00:00

abstract：:The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and...

journal_title：Nature communications

authors： Horstmann JA,Lunelli M,Cazzola H,Heidemann J,Kühne C,Steffen P,Szefs S,Rossi C,Lokareddy RK,Wang C,Lemaire L,Hughes KT,Uetrecht C,Schlüter H,Grassl GA,Stradal TEB,Rossez Y,Kolbe M,Erhardt M

更新日期：2020-04-24 00:00:00

abstract：:In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are u...

journal_title：Nature communications

authors： Murray JE,Belin-Rauscent A,Simon M,Giuliano C,Benoit-Marand M,Everitt BJ,Belin D

更新日期：2015-12-14 00:00:00

abstract：:High-performance piezoelectrics are lead-based solid solutions that exhibit a so-called morphotropic phase boundary, which separates two competing phases as a function of chemical composition; as a consequence, an intermediate low-symmetry phase with a strong piezoelectric effect arises. In search for environmentally ...

journal_title：Nature communications

authors： Lummen TT,Gu Y,Wang J,Lei S,Xue F,Kumar A,Barnes AT,Barnes E,Denev S,Belianinov A,Holt M,Morozovska AN,Kalinin SV,Chen LQ,Gopalan V

更新日期：2014-01-01 00:00:00

abstract：:Angiogenesis is a necessary process for solid tumor growth. Cellular markers for endothelial cell proliferation are potential targets for identifying the vasculature of tumors in homeostasis. Here we customize the behaviors of engineered cells to recognize Apj, a surface marker of the neovascular endothelium, using sy...

journal_title：Nature communications

authors： Wang Z,Wang F,Zhong J,Zhu T,Zheng Y,Zhao T,Xie Q,Ma F,Li R,Tang Q,Xu F,Tian X,Zhu J

更新日期：2020-05-01 00:00:00

abstract：:Myoblast fusion (MF) is required for muscle growth and repair, and its alteration contributes to muscle diseases. The mechanisms governing this process are incompletely understood, and no epigenetic regulator has been previously described. Ash1L is an epigenetic activator belonging to the Trithorax group of proteins a...

journal_title：Nature communications

authors： Castiglioni I,Caccia R,Garcia-Manteiga JM,Ferri G,Caretti G,Molineris I,Nishioka K,Gabellini D

更新日期：2018-11-28 00:00:00

abstract：:Increasing evidence suggests that neural population responses have their own internal drive, or dynamics, that describe how the neural population evolves through time. An important prediction of neural dynamical models is that previously observed neural activity is informative of noisy yet-to-be-observed activity on s...

journal_title：Nature communications

authors： Kao JC,Nuyujukian P,Ryu SI,Churchland MM,Cunningham JP,Shenoy KV

更新日期：2015-07-29 00:00:00

abstract：:Exploitation of the oxidation behaviour in an environmentally sensitive semiconductor is significant to modulate its electronic properties and develop unique applications. Here, we demonstrate a native oxidation-inspired InSe field-effect transistor as an artificial synapse in device level that benefits from the boost...

journal_title：Nature communications

authors： Yang FS,Li M,Lee MP,Ho IY,Chen JY,Ling H,Li Y,Chang JK,Yang SH,Chang YM,Lee KC,Chou YC,Ho CH,Li W,Lien CH,Lin YF

更新日期：2020-06-12 00:00:00