The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.

abstract：:Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however...

journal_title：Nature communications

authors： Fanning SW,Hodges-Gallagher L,Myles DC,Sun R,Fowler CE,Plant IN,Green BD,Harmon CL,Greene GL,Kushner PJ

更新日期：2018-06-18 00:00:00

abstract：:Natural systems frequently exploit intricate multiscale and multiphasic structures to achieve functionalities beyond those of man-made systems. Although understanding the chemical make-up of these systems is essential, the passive and active mechanics within biological systems are crucial when considering the many nat...

journal_title：Nature communications

authors： Egan P,Sinko R,LeDuc PR,Keten S

更新日期：2015-07-06 00:00:00

abstract：:Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites, including 5-methoxytryptophan ...

journal_title：Nature communications

authors： Chen DQ,Cao G,Chen H,Argyopoulos CP,Yu H,Su W,Chen L,Samuels DC,Zhuang S,Bayliss GP,Zhao S,Yu XY,Vaziri ND,Wang M,Liu D,Mao JR,Ma SX,Zhao J,Zhang Y,Shang YQ,Kang H,Ye F,Cheng XH,Li XR,Zhang L,Meng MX,G

更新日期：2019-04-01 00:00:00

abstract：:Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficienc...

journal_title：Nature communications

authors： Kimura T,Nada S,Takegahara N,Okuno T,Nojima S,Kang S,Ito D,Morimoto K,Hosokawa T,Hayama Y,Mitsui Y,Sakurai N,Sarashina-Kida H,Nishide M,Maeda Y,Takamatsu H,Okuzaki D,Yamada M,Okada M,Kumanogoh A

更新日期：2016-10-12 00:00:00

abstract：:Even a single-component liquid may have more than two liquid states. The transition between them is called a 'liquid-liquid transition' (LLT). Such LLTs have recently attracted considerable attention mainly because of the fundamental interest in the physical origin of this counter-intuitive phenomenon. In this study, ...

journal_title：Nature communications

authors： Murata K,Tanaka H

更新日期：2010-05-04 00:00:00

abstract：:Insect vectors are required for the transmission of many species of parasitic nematodes, but the mechanisms by which the vectors and nematodes coordinate their life cycles are poorly understood. Here, we report that ascarosides, an evolutionarily conserved family of nematode pheromones, are produced not only by a plan...

journal_title：Nature communications

authors： Zhao L,Zhang X,Wei Y,Zhou J,Zhang W,Qin P,Chinta S,Kong X,Liu Y,Yu H,Hu S,Zou Z,Butcher RA,Sun J

更新日期：2016-08-01 00:00:00

abstract：:Transition metal reagents and catalysts are generally effective to cleave all three bonds (one σ and two π) in a triple bond despite its high bonding energy. Recently, chemistry of single-bond cleavage by using main-group element compounds is rapidly being developed in the absence of transition metals. However, the cl...

journal_title：Nature communications

authors： Asakawa H,Lee KH,Lin Z,Yamashita M

更新日期：2014-06-26 00:00:00

abstract：:Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...

journal_title：Nature communications

authors： Keller MA,Zander U,Fuchs JE,Kreutz C,Watschinger K,Mueller T,Golderer G,Liedl KR,Ralser M,Kräutler B,Werner ER,Marquez JA

更新日期：2014-07-22 00:00:00

abstract：:Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the effects of averaging...

journal_title：Nature communications

authors： Kuzmanic A,Pannu NS,Zagrovic B

更新日期：2014-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Bradac C,Gao W,Forneris J,Trusheim ME,Aharonovich I

更新日期：2020-01-14 00:00:00

abstract：:Our ability to uncover complex network structure and dynamics from data is fundamental to understanding and controlling collective dynamics in complex systems. Despite recent progress in this area, reconstructing networks with stochastic dynamical processes from limited time series remains to be an outstanding problem...

journal_title：Nature communications

authors： Shen Z,Wang WX,Fan Y,Di Z,Lai YC

更新日期：2014-07-11 00:00:00

abstract：:Between the land and ocean, diverse coastal ecosystems transform, store, and transport material. Across these interfaces, the dynamic exchange of energy and matter is driven by hydrological and hydrodynamic processes such as river and groundwater discharge, tides, waves, and storms. These dynamics regulate ecosystem f...

journal_title：Nature communications

authors： Ward ND,Megonigal JP,Bond-Lamberty B,Bailey VL,Butman D,Canuel EA,Diefenderfer H,Ganju NK,Goñi MA,Graham EB,Hopkinson CS,Khangaonkar T,Langley JA,McDowell NG,Myers-Pigg AN,Neumann RB,Osburn CL,Price RM,Rowland J,Sen

更新日期：2020-05-18 00:00:00

abstract：:Proactive, that is, unsolicited, prosociality is a key component of our hyper-cooperation, which in turn has enabled the emergence of various uniquely human traits, including complex cognition, morality and cumulative culture and technology. However, the evolutionary foundation of the human prosocial sentiment remains...

journal_title：Nature communications

authors： Burkart JM,Allon O,Amici F,Fichtel C,Finkenwirth C,Heschl A,Huber J,Isler K,Kosonen ZK,Martins E,Meulman EJ,Richiger R,Rueth K,Spillmann B,Wiesendanger S,van Schaik CP

更新日期：2014-08-27 00:00:00

abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...

journal_title：Nature communications

authors： Bradshaw CJ,Leroy B,Bellard C,Roiz D,Albert C,Fournier A,Barbet-Massin M,Salles JM,Simard F,Courchamp F

更新日期：2016-10-04 00:00:00

abstract：:The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organiza...

journal_title：Nature communications

authors： Muok AR,Ortega DR,Kurniyati K,Yang W,Maschmann ZA,Sidi Mabrouk A,Li C,Crane BR,Briegel A

更新日期：2020-11-13 00:00:00

abstract：:Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the transcription factor th...

journal_title：Nature communications

authors： Qi Y,Yu J,Han W,Fan X,Qian H,Wei H,Tsai YH,Zhao J,Zhang W,Liu Q,Meng S,Wang Y,Wang Z

更新日期：2016-06-13 00:00:00

abstract：:Two voltage-gated calcium channel subtypes-CaV1.2 and CaV1.3-underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel blockers, such as dihydropy...

journal_title：Nature communications

authors： Huang H,Ng CY,Yu D,Zhai J,Lam Y,Soong TW

更新日期：2014-07-24 00:00:00

abstract：:Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-w...

journal_title：Nature communications

authors： Khanikaev AB,Fleury R,Mousavi SH,Alù A

更新日期：2015-10-06 00:00:00

abstract：:The need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral i...

journal_title：Nature communications

authors： Shan S,Li J,Maswadeh Y,O'Brien C,Kareem H,Tran DT,Lee IC,Wu ZP,Wang S,Yan S,Cronk H,Mott D,Yang L,Luo J,Petkov V,Zhong CJ

更新日期：2020-08-21 00:00:00

abstract：:Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endorib...

journal_title：Nature communications

authors： Yang JY,Deng XY,Li YS,Ma XC,Feng JX,Yu B,Chen Y,Luo YL,Wang X,Chen ML,Fang ZX,Zheng FX,Li YP,Zhong Q,Kang TB,Song LB,Xu RH,Zeng MS,Chen W,Zhang H,Xie W,Gao S

更新日期：2018-03-21 00:00:00

abstract：:Dynamics of molecules in the solid state holds promise for connecting molecular behaviors with properties of bulk materials. Solid-state dynamics of [60]fullerene (C60) is controlled by intimate intermolecular contacts and results in restricted motions of a ratchet phase at low temperatures. Manipulation of the solid-...

journal_title：Nature communications

authors： Matsuno T,Nakai Y,Sato S,Maniwa Y,Isobe H

更新日期：2018-05-15 00:00:00

abstract：:Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...

journal_title：Nature communications

authors： Akakabe Y,Koide M,Kitamura Y,Matsuo K,Ueyama T,Matoba S,Yamada H,Miyata K,Oike Y,Ikeda K

更新日期：2013-01-01 00:00:00

abstract：:The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to unc...

journal_title：Nature communications

authors： Chevreuil M,Law-Hine D,Chen J,Bressanelli S,Combet S,Constantin D,Degrouard J,Möller J,Zeghal M,Tresset G

更新日期：2018-08-06 00:00:00

abstract：:How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and ...

journal_title：Nature communications

authors： Wang S,Drummond ML,Guerrero-Juarez CF,Tarapore E,MacLean AL,Stabell AR,Wu SC,Gutierrez G,That BT,Benavente CA,Nie Q,Atwood SX

更新日期：2020-08-25 00:00:00

abstract：:The majority of mammalian genes contain one or more alternative polyadenylation sites. Choice of polyadenylation sites was suggested as one of the underlying mechanisms for generating longer/shorter transcript isoforms. Here, we demonstrate that mature mRNA transcripts can undergo additional cleavage and polyadenylati...

journal_title：Nature communications

authors： Malka Y,Steiman-Shimony A,Rosenthal E,Argaman L,Cohen-Daniel L,Arbib E,Margalit H,Kaplan T,Berger M

更新日期：2017-12-11 00:00:00

abstract：:Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-...

journal_title：Nature communications

authors： Shibata K,Natsui S,Tobisu M,Fukumoto Y,Chatani N

更新日期：2017-11-13 00:00:00

abstract：:Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...

journal_title：Nature communications

authors： Runge J,Petoukhov V,Donges JF,Hlinka J,Jajcay N,Vejmelka M,Hartman D,Marwan N,Paluš M,Kurths J

更新日期：2015-10-07 00:00:00

abstract：:Martensitic transition is a solid-state phase transition involving cooperative movement of atoms, mostly studied in metallurgy. The main characteristics are low transition barrier, ultrafast kinetics, and structural reversibility. They are rarely observed in molecular crystals, and hence the origin and mechanism are l...

journal_title：Nature communications

authors： Chung H,Dudenko D,Zhang F,D'Avino G,Ruzié C,Richard A,Schweicher G,Cornil J,Beljonne D,Geerts Y,Diao Y

更新日期：2018-01-18 00:00:00

abstract：:Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune mic...

journal_title：Nature communications

authors： Koyama S,Akbay EA,Li YY,Herter-Sprie GS,Buczkowski KA,Richards WG,Gandhi L,Redig AJ,Rodig SJ,Asahina H,Jones RE,Kulkarni MM,Kuraguchi M,Palakurthi S,Fecci PE,Johnson BE,Janne PA,Engelman JA,Gangadharan SP,Costa DB,

更新日期：2016-02-17 00:00:00

abstract：:Protein function and dynamics are closely related; however, accurate dynamics information is difficult to obtain. Here based on a carefully assembled data set derived from experimental data for proteins in solution, we quantify backbone dynamics properties on the amino-acid level and develop DynaMine--a fast, high-qua...

journal_title：Nature communications

authors： Cilia E,Pancsa R,Tompa P,Lenaerts T,Vranken WF

更新日期：2013-01-01 00:00:00