Surface-wetting effects on the liquid-liquid transition of a single-component molecular liquid.

abstract：:Short DNA linkers are increasingly being exploited for driving-specific self-assembly of Brownian objects. DNA-functionalized colloids can assemble into ordered or amorphous materials with tailored morphology. Recently, the same approach has been applied to compliant units, including emulsion droplets and lipid vesicl...

journal_title：Nature communications

authors： Parolini L,Mognetti BM,Kotar J,Eiser E,Cicuta P,Di Michele L

更新日期：2015-01-07 00:00:00

abstract：:VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an optimized Env immu...

journal_title：Nature communications

authors： McGuire AT,Gray MD,Dosenovic P,Gitlin AD,Freund NT,Petersen J,Correnti C,Johnsen W,Kegel R,Stuart AB,Glenn J,Seaman MS,Schief WR,Strong RK,Nussenzweig MC,Stamatatos L

更新日期：2016-02-24 00:00:00

abstract：:Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...

journal_title：Nature communications

authors： Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

更新日期：2020-11-02 00:00:00

abstract：:Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...

journal_title：Nature communications

authors： Nagata K,Takahashi M,Matsuba Y,Okuyama-Uchimura F,Sato K,Hashimoto S,Saito T,Saido TC

更新日期：2018-05-04 00:00:00

abstract：:The properties of antihydrogen are expected to be identical to those of hydrogen, and any differences would constitute a profound challenge to the fundamental theories of physics. The most commonly discussed antiatom-based tests of these theories are searches for antihydrogen-hydrogen spectral differences (tests of CP...

journal_title：Nature communications

authors： Amole C,Ashkezari MD,Baquero-Ruiz M,Bertsche W,Butler E,Capra A,Cesar CL,Charlton M,Eriksson S,Fajans J,Friesen T,Fujiwara MC,Gill DR,Gutierrez A,Hangst JS,Hardy WN,Hayden ME,Isaac CA,Jonsell S,Kurchaninov L,Littl

更新日期：2014-06-03 00:00:00

abstract：:The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH gene. Although LSH belongs to a family of chromatin remodeling proteins, it remains unknown how LSH mediates its function on chromatin in vivo. Here, we use ch...

journal_title：Nature communications

authors： Ni K,Ren J,Xu X,He Y,Finney R,Braun SMG,Hathaway NA,Crabtree GR,Muegge K

更新日期：2020-11-06 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...

journal_title：Nature communications

authors： Jiang H,Zhou C,Zhang Z,Wang Q,Wei H,Shi W,Li J,Wang Z,Ou Y,Wang W,Wang H,Zhang Q,Sun W,Sun P,Yang S

更新日期：2020-10-12 00:00:00

abstract：:The mammary epithelium comprises two primary cellular lineages, but the degree of heterogeneity within these compartments and their lineage relationships during development remain an open question. Here we report single-cell RNA profiling of mouse mammary epithelial cells spanning four developmental stages in the post...

journal_title：Nature communications

authors： Pal B,Chen Y,Vaillant F,Jamieson P,Gordon L,Rios AC,Wilcox S,Fu N,Liu KH,Jackling FC,Davis MJ,Lindeman GJ,Smyth GK,Visvader JE

更新日期：2017-11-20 00:00:00

abstract：:Protein post-translational modifications (PTMs) play important roles in the control of various biological processes including protein-protein interactions, epigenetics and cell cycle regulation. Mass spectrometry-based proteomics approaches enable comprehensive identification and quantitation of numerous types of PTMs...

journal_title：Nature communications

authors： Abshiru N,Caron-Lizotte O,Rajan RE,Jamai A,Pomies C,Verreault A,Thibault P

更新日期：2015-10-15 00:00:00

abstract：:Replacing sluggish oxygen evolution reaction (OER) with hydrazine oxidation reaction (HzOR) to produce hydrogen has been considered as a more energy-efficient strategy than water splitting. However, the relatively high cell voltage in two-electrode system and the required external electric power hinder its scalable ap...

journal_title：Nature communications

authors： Liu Y,Zhang J,Li Y,Qian Q,Li Z,Zhu Y,Zhang G

更新日期：2020-04-15 00:00:00

abstract：:The majority of mammalian genes contain one or more alternative polyadenylation sites. Choice of polyadenylation sites was suggested as one of the underlying mechanisms for generating longer/shorter transcript isoforms. Here, we demonstrate that mature mRNA transcripts can undergo additional cleavage and polyadenylati...

journal_title：Nature communications

authors： Malka Y,Steiman-Shimony A,Rosenthal E,Argaman L,Cohen-Daniel L,Arbib E,Margalit H,Kaplan T,Berger M

更新日期：2017-12-11 00:00:00

abstract：:Diffusion is the result of repeated random scattering. It governs a wide range of phenomena from Brownian motion, to heat flow through window panes, neutron flux in fuel rods, dispersion of light in human tissue, and electronic conduction. It is universally acknowledged that the diffusion approach to describing wave t...

journal_title：Nature communications

authors： Shi Z,Genack AZ

更新日期：2018-05-10 00:00:00

abstract：:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a...

journal_title：Nature communications

authors： Zhu Z,Zheng Z,Zhang F,Wu Y,Trzaskowski M,Maier R,Robinson MR,McGrath JJ,Visscher PM,Wray NR,Yang J

更新日期：2018-01-15 00:00:00

abstract：:Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibito...

journal_title：Nature communications

authors： Liu Q,Deng S,Liu B,Tao Y,Ai H,Liu J,Zhang Y,Zhao Y,Xu M

更新日期：2020-01-24 00:00:00

abstract：:Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...

journal_title：Nature communications

authors： Zhang WS,Pan A,Zhang X,Ying A,Ma G,Liu BL,Qi LW,Liu Q,Li P

更新日期：2019-09-20 00:00:00

abstract：:In the lead-up to the Cretaceous/Paleogene mass extinction, dinosaur diversity is argued to have been either in long-term decline, or thriving until their sudden demise. The latest Cretaceous (Campanian-Maastrichtian [83-66 Ma]) of North America provides the best record to address this debate, but even here diversity ...

journal_title：Nature communications

authors： Chiarenza AA,Mannion PD,Lunt DJ,Farnsworth A,Jones LA,Kelland SJ,Allison PA

更新日期：2019-03-06 00:00:00

abstract：:Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here,...

journal_title：Nature communications

authors： Ron G,Globerson Y,Moran D,Kaplan T

更新日期：2017-12-21 00:00:00

abstract：:Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as well as the location and neighbouring sites of framework aluminium. Unfortunatel...

journal_title：Nature communications

authors： Perea DE,Arslan I,Liu J,Ristanović Z,Kovarik L,Arey BW,Lercher JA,Bare SR,Weckhuysen BM

更新日期：2015-07-02 00:00:00

abstract：:Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...

journal_title：Nature communications

authors： Torres JP,Lin Z,Winter JM,Krug PJ,Schmidt EW

更新日期：2020-06-08 00:00:00

abstract：:Optical phase change materials (O-PCMs), a unique group of materials featuring exceptional optical property contrast upon a solid-state phase transition, have found widespread adoption in photonic applications such as switches, routers and reconfigurable meta-optics. Current O-PCMs, such as Ge-Sb-Te (GST), exhibit lar...

journal_title：Nature communications

authors： Zhang Y,Chou JB,Li J,Li H,Du Q,Yadav A,Zhou S,Shalaginov MY,Fang Z,Zhong H,Roberts C,Robinson P,Bohlin B,Ríos C,Lin H,Kang M,Gu T,Warner J,Liberman V,Richardson K,Hu J

更新日期：2019-09-30 00:00:00

abstract：:Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) gene...

journal_title：Nature communications

authors： Takahashi H,Takigawa I,Watanabe M,Anwar D,Shibata M,Tomomori-Sato C,Sato S,Ranjan A,Seidel CW,Tsukiyama T,Mizushima W,Hayashi M,Ohkawa Y,Conaway JW,Conaway RC,Hatakeyama S

更新日期：2015-01-09 00:00:00

abstract：:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its ...

journal_title：Nature communications

authors： Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen D

更新日期：2019-01-18 00:00:00

abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...

journal_title：Nature communications

authors： Agier N,Delmas S,Zhang Q,Fleiss A,Jaszczyszyn Y,van Dijk E,Thermes C,Weigt M,Cosentino-Lagomarsino M,Fischer G

更新日期：2018-06-06 00:00:00

abstract：:The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...

journal_title：Nature communications

authors： Sajini AA,Choudhury NR,Wagner RE,Bornelöv S,Selmi T,Spanos C,Dietmann S,Rappsilber J,Michlewski G,Frye M

更新日期：2019-06-11 00:00:00

abstract：:Developing earth-abundant, active and stable electrocatalysts which operate in the same electrolyte for water splitting, including oxygen evolution reaction and hydrogen evolution reaction, is important for many renewable energy conversion processes. Here we demonstrate the improvement of catalytic activity when trans...

journal_title：Nature communications

authors： Wang H,Lee HW,Deng Y,Lu Z,Hsu PC,Liu Y,Lin D,Cui Y

更新日期：2015-06-23 00:00:00

abstract：:To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...

journal_title：Nature communications

authors： Matsumura T,Sugawara Y,Yutani M,Amatsu S,Yagita H,Kohda T,Fukuoka S,Nakamura Y,Fukuda S,Hase K,Ohno H,Fujinaga Y

更新日期：2015-02-17 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:The electron deficiency and strong bonding capacity of boron have led to a vast variety of molecular structures in chemistry and materials science. Here we report the observation of highly symmetric cobalt-centered boron drum-like structures of CoB16(-), characterized by photoelectron spectroscopy and ab initio calcul...

journal_title：Nature communications

authors： Popov IA,Jian T,Lopez GV,Boldyrev AI,Wang LS

更新日期：2015-10-12 00:00:00

abstract：:Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole's distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely determine where distal appendage proteins localize in relation to the ...

journal_title：Nature communications

authors： Bowler M,Kong D,Sun S,Nanjundappa R,Evans L,Farmer V,Holland A,Mahjoub MR,Sui H,Loncarek J

更新日期：2019-03-01 00:00:00

abstract：:How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...

journal_title：Nature communications

authors： Helfrich RF,Lendner JD,Mander BA,Guillen H,Paff M,Mnatsakanyan L,Vadera S,Walker MP,Lin JJ,Knight RT

更新日期：2019-08-08 00:00:00