当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments.

Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments.

Abstract：

:The majority of mammalian genes contain one or more alternative polyadenylation sites. Choice of polyadenylation sites was suggested as one of the underlying mechanisms for generating longer/shorter transcript isoforms. Here, we demonstrate that mature mRNA transcripts can undergo additional cleavage and polyadenylation at a proximal internal site in the 3'-UTR, resulting in two stable, autonomous, RNA fragments: a coding sequence with a shorter 3'-UTR (body) and an uncapped 3'-UTR sequence downstream of the cleavage point (tail). Analyses of the human transcriptome has revealed thousands of such cleavage positions, suggesting a widespread post-transcriptional phenomenon producing thousands of stable 3'-UTR RNA tails that exist alongside their transcripts of origin. By analyzing the impact of microRNAs, we observed a significantly stronger effect for microRNA regulation at the body compared to the tail fragments. Our findings open a variety of future research prospects and call for a new perspective on 3'-UTR-dependent gene regulation.

journal_name

Nat Commun

journal_title

Nature communications

authors

Malka Y,Steiman-Shimony A,Rosenthal E,Argaman L,Cohen-Daniel L,Arbib E,Margalit H,Kaplan T,Berger M

doi

10.1038/s41467-017-02099-7

subject

Has Abstract

pub_date

2017-12-11 00:00:00

pages

2029

issue

1

issn

2041-1723

pii

10.1038/s41467-017-02099-7

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Gating mechanism of elongating β-ketoacyl-ACP synthases.

    abstract：:Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple ch...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15455-x

    authors： Mindrebo JT,Patel A,Kim WE,Davis TD,Chen A,Bartholow TG,La Clair JJ,McCammon JA,Noel JP,Burkart MD

    更新日期：2020-04-07 00:00:00

  • Ventral midbrain stimulation induces perceptual learning and cortical plasticity in primates.

    abstract：:Practice improves perception and enhances neural representations of trained visual stimuli, a phenomenon known as visual perceptual learning (VPL). While attention to task-relevant stimuli plays an important role in such learning, Pavlovian stimulus-reinforcer associations are sufficient to drive VPL, even subconsciou...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11527-9

    authors： Arsenault JT,Vanduffel W

    更新日期：2019-08-09 00:00:00

  • Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota.

    abstract：:Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obes...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7495

    authors： Geurts L,Everard A,Van Hul M,Essaghir A,Duparc T,Matamoros S,Plovier H,Castel J,Denis RG,Bergiers M,Druart C,Alhouayek M,Delzenne NM,Muccioli GG,Demoulin JB,Luquet S,Cani PD

    更新日期：2015-03-11 00:00:00

  • IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.

    abstract：:It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17091-x

    authors： Bisi S,Marchesi S,Rizvi A,Carra D,Beznoussenko GV,Ferrara I,Deflorian G,Mironov A,Bertalot G,Pisati F,Oldani A,Cattaneo A,Saberamoli G,Pece S,Viale G,Bachi A,Tripodo C,Scita G,Disanza A

    更新日期：2020-07-14 00:00:00

  • Mutational interactions define novel cancer subgroups.

    abstract：:Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network model for tumour mu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06867-x

    authors： Kuipers J,Thurnherr T,Moffa G,Suter P,Behr J,Goosen R,Christofori G,Beerenwinkel N

    更新日期：2018-10-19 00:00:00

  • Characterizing large-scale quantum computers via cycle benchmarking.

    abstract：:Quantum computers promise to solve certain problems more efficiently than their digital counterparts. A major challenge towards practically useful quantum computing is characterizing and reducing the various errors that accumulate during an algorithm running on large-scale processors. Current characterization techniqu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13068-7

    authors： Erhard A,Wallman JJ,Postler L,Meth M,Stricker R,Martinez EA,Schindler P,Monz T,Emerson J,Blatt R

    更新日期：2019-11-25 00:00:00

  • Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis.

    abstract：:Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19880-w

    authors： Lee CY,Cheu RK,Lemke MM,Gustin AT,France MT,Hampel B,Thurman AR,Doncel GF,Ravel J,Klatt NR,Arnold KB

    更新日期：2020-12-01 00:00:00

  • Unpredictable environments lead to the evolution of parental neglect in birds.

    abstract：:A nest of begging chicks invites an intuitive explanation: needy chicks want to be fed and parents want to feed them. Surprisingly, however, in a quarter of species studied, parents ignore begging chicks. Furthermore, parents in some species even neglect smaller chicks that beg more, and preferentially feed the bigges...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10985

    authors： Caro SM,Griffin AS,Hinde CA,West SA

    更新日期：2016-03-29 00:00:00

  • Human large-scale cooperation as a product of competition between cultural groups.

    abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14416-8

    authors： Handley C,Mathew S

    更新日期：2020-02-04 00:00:00

  • Closing the gap between palaeontological and neontological speciation and extinction rate estimates.

    abstract：:Measuring the pace at which speciation and extinction occur is fundamental to understanding the origin and evolution of biodiversity. Both the fossil record and molecular phylogenies of living species can provide independent estimates of speciation and extinction rates, but often produce strikingly divergent results. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07622-y

    authors： Silvestro D,Warnock RCM,Gavryushkina A,Stadler T

    更新日期：2018-12-07 00:00:00

  • Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.

    abstract：:Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transgene, commonly used to target the mammary gland during pregnancy, indu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15585-2

    authors： Chung PED,Gendoo DMA,Ghanbari-Azarnier R,Liu JC,Jiang Z,Tsui J,Wang DY,Xiao X,Li B,Dubuc A,Shih D,Remke M,Ho B,Garzia L,Ben-David Y,Kang SG,Croul S,Haibe-Kains B,Huang A,Taylor MD,Zacksenhaus E

    更新日期：2020-04-14 00:00:00

  • Societal decisions about climate mitigation will have dramatic impacts on eutrophication in the 21st century.

    abstract：:Excessive nitrogen runoff leads to degraded water quality, harming human and ecosystem health. We examine the impact of changes in land use and land management for six combinations of socioeconomic pathways and climate outcomes, and find that societal choices will substantially impact riverine total nitrogen loading (...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08884-w

    authors： Sinha E,Michalak AM,Calvin KV,Lawrence PJ

    更新日期：2019-02-26 00:00:00

  • Author Correction: The future of Blue Carbon science.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-13126-0

    authors： Macreadie PI,Anton A,Raven JA,Beaumont N,Connolly RM,Friess DA,Kelleway JJ,Kennedy H,Kuwae T,Lavery PS,Lovelock CE,Smale DA,Apostolaki ET,Atwood TB,Baldock J,Bianchi TS,Chmura GL,Eyre BD,Fourqurean JW,Hall-Spencer J

    更新日期：2019-11-08 00:00:00

  • Vertical organic permeable dual-base transistors for logic circuits.

    abstract：:The main advantage of organic transistors with dual gates/bases is that the threshold voltages can be set as a function of the applied second gate/base bias, which is crucial for the application in logic gates and integrated circuits. However, incorporating a dual gate/base structure into an ultra-short channel vertic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18576-5

    authors： Guo E,Wu Z,Darbandy G,Xing S,Wang SJ,Tahn A,Göbel M,Kloes A,Leo K,Kleemann H

    更新日期：2020-09-18 00:00:00

  • The composition of British bird communities is associated with long-term garden bird feeding.

    abstract：:There is a multi-billion dollar global industry dedicated to feeding wild birds in residential gardens. This extraordinary boost to food resources is almost certainly reshaping entire bird communities, yet the large-scale, long-term impacts on community ecology remain unknown. Here we reveal a 40-year transformation o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10111-5

    authors： Plummer KE,Risely K,Toms MP,Siriwardena GM

    更新日期：2019-05-21 00:00:00

  • Emergence of orbital angular moment at van Hove singularity in graphene/h-BN moiré superlattice.

    abstract：:Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19043-x

    authors： Moriya R,Kinoshita K,Crosse JA,Watanabe K,Taniguchi T,Masubuchi S,Moon P,Koshino M,Machida T

    更新日期：2020-10-23 00:00:00

  • Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis.

    abstract：:During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07448-8

    authors： Kale GR,Yang X,Philippe JM,Mani M,Lenne PF,Lecuit T

    更新日期：2018-11-27 00:00:00

  • Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.

    abstract：:In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While lo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16971-6

    authors： Assaraf E,Blecher R,Heinemann-Yerushalmi L,Krief S,Carmel Vinestock R,Biton IE,Brumfeld V,Rotkopf R,Avisar E,Agar G,Zelzer E

    更新日期：2020-06-23 00:00:00

  • Chemical engineering of quasicrystal approximants in lanthanide-based coordination solids.

    abstract：:Tessellation of self-assembling molecular building blocks is a promising strategy to design metal-organic materials exhibiting geometrical frustration and ensuing frustrated physical properties. Appearing in two-dimensional quasiperiodic phases, tilings consisting of five-vertex nodes are regarded as approximants for ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18328-5

    authors： Voigt L,Kubus M,Pedersen KS

    更新日期：2020-09-17 00:00:00

  • Understanding crystallization pathways leading to manganese oxide polymorph formation.

    abstract：:Hydrothermal synthesis is challenging in metal oxide systems with diverse polymorphism, as reaction products are often sensitive to subtle variations in synthesis parameters. This sensitivity is rooted in the non-equilibrium nature of low-temperature crystallization, where competition between different metastable phas...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04917-y

    authors： Chen BR,Sun W,Kitchaev DA,Mangum JS,Thampy V,Garten LM,Ginley DS,Gorman BP,Stone KH,Ceder G,Toney MF,Schelhas LT

    更新日期：2018-06-29 00:00:00

  • Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores.

    abstract：:Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06534-1

    authors： Galenkamp NS,Soskine M,Hermans J,Wloka C,Maglia G

    更新日期：2018-10-05 00:00:00

  • Author Correction: Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion.

    abstract：:The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'A patent has been applied for by Emory University with F.E.L, I.S. and D.C. N. as named inventors. The patent application number is PCT/US2016/036650'. This has now been correct...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-019-08400-0

    authors： Nguyen DC,Garimalla S,Xiao H,Kyu S,Albizua I,Galipeau J,Chiang KY,Waller EK,Wu R,Gibson G,Roberson J,Lund FE,Randall TD,Sanz I,Lee FE

    更新日期：2019-01-17 00:00:00

  • Rapid single-wavelength lightsheet localization microscopy for clarified tissue.

    abstract：:Optical super-resolution microscopy allows nanoscale imaging of protein molecules in intact biological tissues. However, it is still challenging to perform large volume super-resolution imaging for entire animal organs. Here we develop a single-wavelength Bessel lightsheet method, optimized for refractive-index matchi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12715-3

    authors： Chu LA,Lu CH,Yang SM,Liu YT,Feng KL,Tsai YC,Chang WK,Wang WC,Chang SW,Chen P,Lee TK,Hwu YK,Chiang AS,Chen BC

    更新日期：2019-10-18 00:00:00

  • Surface cooling caused by rare but intense near-inertial wave induced mixing in the tropical Atlantic.

    abstract：:The direct response of the tropical mixed layer to near-inertial waves (NIWs) has only rarely been observed. Here, we present upper-ocean turbulence data that provide evidence for a strongly elevated vertical diffusive heat flux across the base of the mixed layer in the presence of a NIW, thereby cooling the mixed lay...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17601-x

    authors： Hummels R,Dengler M,Rath W,Foltz GR,Schütte F,Fischer T,Brandt P

    更新日期：2020-07-31 00:00:00

  • Consistent population declines but idiosyncratic range shifts in Alpine orchids under global change.

    abstract：:Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19680-2

    authors： Geppert C,Perazza G,Wilson RJ,Bertolli A,Prosser F,Melchiori G,Marini L

    更新日期：2020-11-17 00:00:00

  • Processive chitinase is Brownian monorail operated by fast catalysis after peeling rail from crystalline chitin.

    abstract：:Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin driven by processive hydrolysis of single chitin chain. Here, we analyse the mechanism underlying unidirectional movement of Serratia marcescens chitinase A (SmChiA) using high-precision single-molecule imaging, X-ray cry...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06362-3

    authors： Nakamura A,Okazaki KI,Furuta T,Sakurai M,Iino R

    更新日期：2018-09-19 00:00:00

  • Coordinated force generation of skeletal myosins in myofilaments through motor coupling.

    abstract：:In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms16036

    authors： Kaya M,Tani Y,Washio T,Hisada T,Higuchi H

    更新日期：2017-07-06 00:00:00

  • Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.

    abstract：:Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12264-9

    authors： Condon MD,Platt NJ,Zhang YF,Roberts BM,Clements MA,Vietti-Michelina S,Tseu MY,Brimblecombe KR,Threlfell S,Mann EO,Cragg SJ

    更新日期：2019-09-19 00:00:00

  • Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.

    abstract：:Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain barrier (BBB) formation. BBB formation and modulation are not only important for development, but also relevant for vascular and neurodegenerative diseases. However, there is little understanding of how Wnt signaling c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07302-x

    authors： Hübner K,Cabochette P,Diéguez-Hurtado R,Wiesner C,Wakayama Y,Grassme KS,Hubert M,Guenther S,Belting HG,Affolter M,Adams RH,Vanhollebeke B,Herzog W

    更新日期：2018-11-19 00:00:00

  • The nuclear pore complex prevents sister chromatid recombination during replicative senescence.

    abstract：:The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation. This Nup1 modification also impairs the reloc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13979-5

    authors： Aguilera P,Whalen J,Minguet C,Churikov D,Freudenreich C,Simon MN,Géli V

    更新日期：2020-01-09 00:00:00