Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.

abstract：:How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...

journal_title：Nature communications

authors： Feng K,Sen R,Minegishi R,Dübbert M,Bockemühl T,Büschges A,Dickson BJ

更新日期：2020-12-02 00:00:00

abstract：:Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, epithelial growth factor (EGF) or transferrin. Here we examine the role of two-pore channel (TPC) 2, an endolysosomal cation channel, in thes...

journal_title：Nature communications

authors： Grimm C,Holdt LM,Chen CC,Hassan S,Müller C,Jörs S,Cuny H,Kissing S,Schröder B,Butz E,Northoff B,Castonguay J,Luber CA,Moser M,Spahn S,Lüllmann-Rauch R,Fendel C,Klugbauer N,Griesbeck O,Haas A,Mann M,Bracher F,T

更新日期：2014-08-21 00:00:00

abstract：:Type I CRISPR-Cas loci provide prokaryotes with a nucleic-acid-based adaptive immunity against foreign DNA. Immunity involves adaptation, the integration of ~30-bp DNA fragments, termed prespacers, into the CRISPR array as spacers, and interference, the targeted degradation of DNA containing a protospacer. Interferenc...

journal_title：Nature communications

authors： Shiriaeva AA,Savitskaya E,Datsenko KA,Vvedenskaya IO,Fedorova I,Morozova N,Metlitskaya A,Sabantsev A,Nickels BE,Severinov K,Semenova E

更新日期：2019-10-10 00:00:00

abstract：:Lithium metal is an ideal anode for lithium batteries due to its low electrochemical potential and high theoretical capacity. However, safety issues arising from lithium dendrite growth have significantly reduced the practical applicability of lithium metal batteries. Here, we report the addition of octaphenyl polyoxy...

journal_title：Nature communications

authors： Dai H,Gu X,Dong J,Wang C,Lai C,Sun S

更新日期：2020-01-31 00:00:00

abstract：:Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...

journal_title：Nature communications

authors： Tian Z,Xu B,Wan G,Han X,Di Z,Chen Z,Mei Y

更新日期：2021-01-21 00:00:00

abstract：:In order to model realistic quantum devices it is necessary to simulate quantum systems strongly coupled to their environment. To date, most understanding of open quantum systems is restricted either to weak system-bath couplings or to special cases where specific numerical techniques become effective. Here we present...

journal_title：Nature communications

authors： Strathearn A,Kirton P,Kilda D,Keeling J,Lovett BW

更新日期：2018-08-20 00:00:00

abstract：:The ability to fabricate nanoscale domains of uniform size in two-dimensional materials could potentially enable new applications in nanoelectronics and the development of innovative metamaterials. However, achieving even minimal control over the growth of two-dimensional lateral heterostructures at such extreme dimen...

journal_title：Nature communications

authors： Camilli L,Jørgensen JH,Tersoff J,Stoot AC,Balog R,Cassidy A,Sadowski JT,Bøggild P,Hornekær L

更新日期：2017-06-29 00:00:00

abstract：:To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...

journal_title：Nature communications

authors： Matsumura T,Sugawara Y,Yutani M,Amatsu S,Yagita H,Kohda T,Fukuoka S,Nakamura Y,Fukuda S,Hase K,Ohno H,Fujinaga Y

更新日期：2015-02-17 00:00:00

abstract：:The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs...

journal_title：Nature communications

authors： Miyawaki S,Kawamura Y,Oiwa Y,Shimizu A,Hachiya T,Bono H,Koya I,Okada Y,Kimura T,Tsuchiya Y,Suzuki S,Onishi N,Kuzumaki N,Matsuzaki Y,Narita M,Ikeda E,Okanoya K,Seino K,Saya H,Okano H,Miura K

更新日期：2016-05-10 00:00:00

abstract：:A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...

journal_title：Nature communications

authors： Gusarov I,Pani B,Gautier L,Smolentseva O,Eremina S,Shamovsky I,Katkova-Zhukotskaya O,Mironov A,Nudler E

更新日期：2017-06-19 00:00:00

abstract：:Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still debated. Here, we first highlight how the different types of f...

journal_title：Nature communications

authors： Passelègue FX,Almakari M,Dublanchet P,Barras F,Fortin J,Violay M

更新日期：2020-10-12 00:00:00

abstract：:The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant, we find that it exhibits extensive cell-type-specific interactions that contribute to cell identity. Here, w...

journal_title：Nature communications

authors： Kai Y,Andricovich J,Zeng Z,Zhu J,Tzatsos A,Peng W

更新日期：2018-10-11 00:00:00

abstract：:Assessing the physical connections and allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal structures available to show their overall structural organizations. Here we report the quaternary architecture of multi-domain retinoic acid receptor β-retinoi...

journal_title：Nature communications

authors： Chandra V,Wu D,Li S,Potluri N,Kim Y,Rastinejad F

更新日期：2017-10-11 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...

journal_title：Nature communications

authors： Spreng RN,Dimas E,Mwilambwe-Tshilobo L,Dagher A,Koellinger P,Nave G,Ong A,Kernbach JM,Wiecki TV,Ge T,Li Y,Holmes AJ,Yeo BTT,Turner GR,Dunbar RIM,Bzdok D

更新日期：2020-12-15 00:00:00

abstract：:The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'A patent has been applied for by Emory University with F.E.L, I.S. and D.C. N. as named inventors. The patent application number is PCT/US2016/036650'. This has now been correct...

journal_title：Nature communications

authors： Nguyen DC,Garimalla S,Xiao H,Kyu S,Albizua I,Galipeau J,Chiang KY,Waller EK,Wu R,Gibson G,Roberson J,Lund FE,Randall TD,Sanz I,Lee FE

更新日期：2019-01-17 00:00:00

abstract：:Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, including cancer and neurological disorders. While BER is well studied on naked DNA, it remains uncl...

journal_title：Nature communications

authors： Montaldo NP,Bordin DL,Brambilla A,Rösinger M,Fordyce Martin SL,Bjørås KØ,Bradamante S,Aas PA,Furrer A,Olsen LC,Kunath N,Otterlei M,Sætrom P,Bjørås M,Samson LD,van Loon B

更新日期：2019-11-29 00:00:00

abstract：:Third generation sequencing technologies provide the opportunity to improve genome assemblies by generating long reads spanning most repeat sequences. However, current analysis methods require substantial amounts of sequence data and computational resources to overcome the high error rates. Furthermore, they can only ...

journal_title：Nature communications

authors： Cao MD,Nguyen SH,Ganesamoorthy D,Elliott AG,Cooper MA,Coin LJ

更新日期：2017-02-20 00:00:00

abstract：:Time-resolved photoelectron spectroscopy (TRPES) is a useful approach to elucidate the coupled electronic-nuclear quantum dynamics underlying chemical processes, but has remained limited by the use of low photon energies. Here, we demonstrate the general advantages of XUV-TRPES through an application to NO2, one of th...

journal_title：Nature communications

authors： von Conta A,Tehlar A,Schletter A,Arasaki Y,Takatsuka K,Wörner HJ

更新日期：2018-08-08 00:00:00

abstract：:Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...

journal_title：Nature communications

authors： Sant'Anna R,Gallego P,Robinson LZ,Pereira-Henriques A,Ferreira N,Pinheiro F,Esperante S,Pallares I,Huertas O,Almeida MR,Reixach N,Insa R,Velazquez-Campoy A,Reverter D,Reig N,Ventura S

更新日期：2016-02-23 00:00:00

abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...

journal_title：Nature communications

authors： Tabatabaei SK,Wang B,Athreya NBM,Enghiad B,Hernandez AG,Fields CJ,Leburton JP,Soloveichik D,Zhao H,Milenkovic O

更新日期：2020-04-08 00:00:00

abstract：:In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are u...

journal_title：Nature communications

authors： Murray JE,Belin-Rauscent A,Simon M,Giuliano C,Benoit-Marand M,Everitt BJ,Belin D

更新日期：2015-12-14 00:00:00

abstract：:Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...

journal_title：Nature communications

authors： Cerna R,Léger Y,Paraïso TK,Wouters M,Morier-Genoud F,Portella-Oberli MT,Deveaud B

更新日期：2013-01-01 00:00:00

abstract：:Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their dur...

journal_title：Nature communications

authors： He C,Duan X,Guo N,Chan C,Poon C,Weichselbaum RR,Lin W

更新日期：2016-08-17 00:00:00

abstract：:Homeowners around the world elevate houses to manage flood risks. Deciding how high to elevate a house poses a nontrivial decision problem. The U.S. Federal Emergency Management Agency (FEMA) recommends elevating existing houses to the Base Flood Elevation (the elevation of the 100-year flood) plus a freeboard. This r...

journal_title：Nature communications

authors： Zarekarizi M,Srikrishnan V,Keller K

更新日期：2020-10-26 00:00:00

abstract：:Woody (lignocellulosic) plant biomass is an abundant renewable feedstock, rich in polysaccharides that are bound into an insoluble fiber composite with lignin. Marine crustacean woodborers of the genus Limnoria are among the few animals that can survive on a diet of this recalcitrant material without relying on gut re...

journal_title：Nature communications

authors： Besser K,Malyon GP,Eborall WS,Paro da Cunha G,Filgueiras JG,Dowle A,Cruz Garcia L,Page SJ,Dupree R,Kern M,Gomez LD,Li Y,Elias L,Sabbadin F,Mohamad SE,Pesante G,Steele-King C,Ribeiro de Azevedo E,Polikarpov I,Dupree

更新日期：2018-12-03 00:00:00

abstract：:Predicting and controlling quantum mechanical phenomena require knowledge of the system Hamiltonian. A detailed understanding of the quantum pathways used to construct the Hamiltonian is essential for deterministic control and improved performance of coherent control schemes. In complex systems, parameters characteriz...

journal_title：Nature communications

authors： Li H,Bristow AD,Siemens ME,Moody G,Cundiff ST

更新日期：2013-01-01 00:00:00

abstract：:Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts to identify host factors have produced largely divergent results, with few overlapping hits across different st...

journal_title：Nature communications

authors： Li B,Clohisey SM,Chia BS,Wang B,Cui A,Eisenhaure T,Schweitzer LD,Hoover P,Parkinson NJ,Nachshon A,Smith N,Regan T,Farr D,Gutmann MU,Bukhari SI,Law A,Sangesland M,Gat-Viks I,Digard P,Vasudevan S,Lingwood D,Dockre

更新日期：2020-01-09 00:00:00

abstract：:The complexity embedded in condensed matter fertilizes the discovery of new states of matter, enriched by ingredients like frustration. Illustrating examples in magnetic systems are Kitaev spin liquids, skyrmions phases, or spin ices. These unconventional ground states support exotic excitations, for example the magne...

journal_title：Nature communications

authors： Lefrançois E,Cathelin V,Lhotel E,Robert J,Lejay P,Colin CV,Canals B,Damay F,Ollivier J,Fåk B,Chapon LC,Ballou R,Simonet V

更新日期：2017-08-08 00:00:00

abstract：:Plasmids are important members of the bacterial mobile gene pool, and are among the most important contributors to horizontal gene transfer between bacteria. They typically harbour a wide spectrum of host beneficial traits, such as antibiotic resistance, inserted into their backbones. Although these inserted elements ...

journal_title：Nature communications

authors： Norberg P,Bergström M,Jethava V,Dubhashi D,Hermansson M

更新日期：2011-01-01 00:00:00