Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.

abstract：:Patterns in biomass production are determined by resource input (productivity) and trophic transfer efficiency. At fixed resource input, variation in consumer biomass production has been related to food quality, metabolic type and diversity among species. In contrast, intraspecific variation in individual body size be...

journal_title：Nature communications

authors： Reichstein B,Persson L,De Roos AM

更新日期：2015-03-04 00:00:00

abstract：:Peridotite carbonation represents a critical step within the long-term carbon cycle by sequestering volatile CO2 in solid carbonate. This has been proposed as one potential pathway to mitigate the effects of greenhouse gas release. Most of our current understanding of reaction mechanisms is based on hand specimen and ...

journal_title：Nature communications

authors： Tominaga M,Beinlich A,Lima EA,Tivey MA,Hampton BA,Weiss B,Harigane Y

更新日期：2017-11-30 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to aerobic glycolysis in tumour cells. However, the mechanisms by w...

journal_title：Nature communications

authors： Balic JJ,Albargy H,Luu K,Kirby FJ,Jayasekara WSN,Mansell F,Garama DJ,De Nardo D,Baschuk N,Louis C,Humphries F,Fitzgerald K,Latz E,Gough DJ,Mansell A

更新日期：2020-07-30 00:00:00

abstract：:Microelectromechanical systems (MEMS) enable many modern-day technologies, including actuators, motion sensors, drug delivery systems, projection displays, etc. Currently, MEMS fabrication techniques are primarily based on silicon micromachining processes, resulting in rigid and low aspect ratio structures. In this st...

journal_title：Nature communications

authors： Khudiyev T,Clayton J,Levy E,Chocat N,Gumennik A,Stolyarov AM,Joannopoulos J,Fink Y

更新日期：2017-11-10 00:00:00

abstract：:Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This process transfers the latent magnetism of para-hydrogen into a substrate, without changing its chemical identity, to dramatically improve its nuclear ma...

journal_title：Nature communications

authors： Rayner PJ,Norcott P,Appleby KM,Iali W,John RO,Hart SJ,Whitwood AC,Duckett SB

更新日期：2018-10-12 00:00:00

abstract：:The Aharonov-Bohm effect is one of the most intriguing phenomena in both classical and quantum physics, and associates with a number of important and fundamental issues in quantum mechanics. The Aharonov-Bohm effects of charged particles have been experimentally demonstrated and found applications in various fields. R...

journal_title：Nature communications

authors： Li E,Eggleton BJ,Fang K,Fan S

更新日期：2014-01-01 00:00:00

abstract：:The actin-like protein MreB has been proposed to coordinate the synthesis of the cell wall to determine cell shape in bacteria. MreB is preferentially localized to areas of the cell with specific curved geometries, avoiding the cell poles. It remains unclear whether MreB's curvature preference is regulated by addition...

journal_title：Nature communications

authors： Bratton BP,Shaevitz JW,Gitai Z,Morgenstein RM

更新日期：2018-07-18 00:00:00

abstract：:Alkaline-urea aqueous solvent system provides a novel and important approach for the utilization of polysaccharide. As one of the most important polysaccharide, chitosan can be well dissolved in this solvent system, and the resultant hydrogel material possesses unique and excellent properties. Thus the sound understan...

journal_title：Nature communications

authors： Wang Z,Nie J,Qin W,Hu Q,Tang BZ

更新日期：2016-06-23 00:00:00

abstract：:TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contrast to its closest s...

journal_title：Nature communications

authors： Demircioglu FE,Zheng W,McQuown AJ,Maier NK,Watson N,Cheeseman IM,Denic V,Egelman EH,Schwartz TU

更新日期：2019-07-22 00:00:00

abstract：:Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are poorly understood. Here we show that PI3Kα regulates endothelial cell rearrangements using a combination of a PI3Kα-selective inhibitor and endothelial-specific...

journal_title：Nature communications

authors： Angulo-Urarte A,Casado P,Castillo SD,Kobialka P,Kotini MP,Figueiredo AM,Castel P,Rajeeve V,Milà-Guasch M,Millan J,Wiesner C,Serra H,Muixi L,Casanovas O,Viñals F,Affolter M,Gerhardt H,Huveneers S,Belting HG,Cutillas

更新日期：2018-11-16 00:00:00

abstract：:Understanding how evolution of antimicrobial resistance increases resistance to other drugs is a challenge of profound importance. By combining experimental evolution and genome sequencing of 63 laboratory-evolved lines, we charted a map of cross-resistance interactions between antibiotics in Escherichia coli, and exp...

journal_title：Nature communications

authors： Lázár V,Nagy I,Spohn R,Csörgő B,Györkei Á,Nyerges Á,Horváth B,Vörös A,Busa-Fekete R,Hrtyan M,Bogos B,Méhi O,Fekete G,Szappanos B,Kégl B,Papp B,Pál C

更新日期：2014-07-08 00:00:00

abstract：:A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-bi...

journal_title：Nature communications

authors： Tan TC,Kracher D,Gandini R,Sygmund C,Kittl R,Haltrich D,Hällberg BM,Ludwig R,Divne C

更新日期：2015-07-07 00:00:00

abstract：:Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...

journal_title：Nature communications

authors： Zhu J,Zhang S,Zhang K,Wang X,Mays JW,Wooley KL,Pochan DJ

更新日期：2013-01-01 00:00:00

abstract：:The discovery of charge- and spin-density-wave (CDW/SDW) orders in superconducting cuprates has altered our perspective on the nature of high-temperature superconductivity (SC). However, it has proven difficult to fully elucidate the relationship between the density wave orders and SC. Here, using resonant soft X-ray ...

journal_title：Nature communications

authors： Wen JJ,Huang H,Lee SJ,Jang H,Knight J,Lee YS,Fujita M,Suzuki KM,Asano S,Kivelson SA,Kao CC,Lee JS

更新日期：2019-07-22 00:00:00

abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

journal_title：Nature communications

authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

更新日期：2018-08-08 00:00:00

abstract：:AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-e...

journal_title：Nature communications

authors： Xu Y,Man N,Karl D,Martinez C,Liu F,Sun J,Martinez CJ,Martin GM,Beckedorff F,Lai F,Yue J,Roisman A,Greenblatt S,Duffort S,Wang L,Sun X,Figueroa M,Shiekhattar R,Nimer S

更新日期：2019-10-29 00:00:00

abstract：:dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here we report that dDsk2 plays a nonproteolytic function in transcription regulation. dDsk2 interacts with the dHP1c complex, localizes at promoters of developmental genes and is required for transcription. T...

journal_title：Nature communications

authors： Kessler R,Tisserand J,Font-Burgada J,Reina O,Coch L,Attolini CS,Garcia-Bassets I,Azorín F

更新日期：2015-04-28 00:00:00

abstract：:Drought comprehensively affects different interlinked aspects of the terrestrial water cycle, which have so far been mostly investigated without direct comparison. Resolving the partitioning of water deficit during drought into blue-water runoff and green-water evapotranspiration fluxes is critical, as anomalies in th...

journal_title：Nature communications

authors： Orth R,Destouni G

更新日期：2018-09-06 00:00:00

abstract：:Enantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving s...

journal_title：Nature communications

authors： Yoneda N,Fujii Y,Matsumoto A,Asano K,Matsubara S

更新日期：2017-11-09 00:00:00

abstract：:Electron-rich dienes have revolutionized the synthesis of complex compounds since the discovery of the legendary Diels-Alder cycloaddition reaction. This highly efficient bond-forming process has served as a fundamental strategy to assemble many structurally formidable molecules. Amino silyloxy butadienes are arguably...

journal_title：Nature communications

authors： Li X,Peng S,Li L,Huang Y

更新日期：2015-04-21 00:00:00

abstract：:The ability to identify cause-effect relations is an essential component of the scientific method. The identification of causal relations is generally accomplished through statistical trials where alternative hypotheses are tested against each other. Traditionally, such trials have been based on classical statistics. ...

journal_title：Nature communications

authors： Chiribella G,Ebler D

更新日期：2019-04-01 00:00:00

abstract：:Alike materials in the solid state, the phase diagram of type-II superconductors exhibit crystalline, amorphous, liquid and spatially inhomogeneous phases. The multitude of different phases of vortex matter has thence proven to act as almost ideal model system for the study of both the underlying properties of superco...

journal_title：Nature communications

authors： Reimann T,Mühlbauer S,Schulz M,Betz B,Kaestner A,Pipich V,Böni P,Grünzweig C

更新日期：2015-11-02 00:00:00

abstract：:A declining rate of recovery following disturbance has been proposed as an important early warning for impending tipping points in complex systems. Despite extensive theoretical and laboratory studies, this 'critical slowing down' remains largely untested in the complex settings of real-world ecosystems. Here, we prov...

journal_title：Nature communications

authors： van Belzen J,van de Koppel J,Kirwan ML,van der Wal D,Herman PMJ,Dakos V,Kéfi S,Scheffer M,Guntenspergen GR,Bouma TJ

更新日期：2017-06-09 00:00:00

abstract：:Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions a...

journal_title：Nature communications

authors： Cao Q,Wang X,Zhao M,Yang R,Malik R,Qiao Y,Poliakov A,Yocum AK,Li Y,Chen W,Cao X,Jiang X,Dahiya A,Harris C,Feng FY,Kalantry S,Qin ZS,Dhanasekaran SM,Chinnaiyan AM

更新日期：2014-01-01 00:00:00

abstract：:Frequency tuning within the auditory papilla of most non-mammalian species is electrical, deriving from ion-channel resonance within their sensory hair cells. In contrast, tuning within the mammalian cochlea is mechanical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane travel...

journal_title：Nature communications

authors： Xia A,Liu X,Raphael PD,Applegate BE,Oghalai JS

更新日期：2016-10-31 00:00:00

abstract：:The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states wi...

journal_title：Nature communications

authors： Adio S,Senyushkina T,Peske F,Fischer N,Wintermeyer W,Rodnina MV

更新日期：2015-06-15 00:00:00

abstract：:Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...

journal_title：Nature communications

authors： Weierstall U,James D,Wang C,White TA,Wang D,Liu W,Spence JC,Bruce Doak R,Nelson G,Fromme P,Fromme R,Grotjohann I,Kupitz C,Zatsepin NA,Liu H,Basu S,Wacker D,Han GW,Katritch V,Boutet S,Messerschmidt M,Williams GJ

更新日期：2014-01-01 00:00:00

abstract：:Metal ions at the active site of an enzyme act as cofactors, and their dynamic fluctuations can potentially influence enzyme activity. Here, we use λ-exonuclease as a model enzyme with two Mg2+ binding sites and probe activity at various concentrations of magnesium by single-molecule-FRET. We find that while MgA2+ and...

journal_title：Nature communications

authors： Hwang W,Yoo J,Lee Y,Park S,Hoang PL,Cho H,Yu J,Hoa Vo TM,Shin M,Jin MS,Park D,Hyeon C,Lee G

更新日期：2018-10-23 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enha...

journal_title：Nature communications

authors： Lu Y,Meng R,Wang X,Xu Y,Tang Y,Wu J,Xue Q,Yu S,Duan M,Shan D,Wang Q,Wang H,Billiar TR,Xiao X,Chen F,Lu B

更新日期：2019-09-06 00:00:00