Abstract:
:Understanding how evolution of antimicrobial resistance increases resistance to other drugs is a challenge of profound importance. By combining experimental evolution and genome sequencing of 63 laboratory-evolved lines, we charted a map of cross-resistance interactions between antibiotics in Escherichia coli, and explored the driving evolutionary principles. Here, we show that (1) convergent molecular evolution is prevalent across antibiotic treatments, (2) resistance conferring mutations simultaneously enhance sensitivity to many other drugs and (3) 27% of the accumulated mutations generate proteins with compromised activities, suggesting that antibiotic adaptation can partly be achieved without gain of novel function. By using knowledge on antibiotic properties, we examined the determinants of cross-resistance and identified chemogenomic profile similarity between antibiotics as the strongest predictor. In contrast, cross-resistance between two antibiotics is independent of whether they show synergistic effects in combination. These results have important implications on the development of novel antimicrobial strategies.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lázár V,Nagy I,Spohn R,Csörgő B,Györkei Á,Nyerges Á,Horváth B,Vörös A,Busa-Fekete R,Hrtyan M,Bogos B,Méhi O,Fekete G,Szappanos B,Kégl B,Papp B,Pál Cdoi
10.1038/ncomms5352subject
Has Abstractpub_date
2014-07-08 00:00:00pages
4352issn
2041-1723pii
ncomms5352journal_volume
5pub_type
杂志文章abstract::The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-18780-3
更新日期:2020-10-06 00:00:00
abstract::In most applications of nanoporous materials the pore structure is as important as the chemical composition as a determinant of performance. For example, one can alter performance in applications like carbon capture or methane storage by orders of magnitude by only modifying the pore structure. For these applications ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15396
更新日期:2017-05-23 00:00:00
abstract::Development of efficient catalysts for selective electroreduction of CO2 to high-value products is essential for the deployment of carbon utilization technologies. Here we present a scalable method for preparing Cu electrocatalysts that favor CO2 conversion to C2+ products with faradaic efficiencies up to 72%. Grazing...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16998-9
更新日期:2020-07-17 00:00:00
abstract::Histone acetylation is known to affect the speed of seed germination, but the molecular regulatory basis of this remains ambiguous. Here we report that loss of function of two histone deacetylase-binding factors, SWI-INDEPENDENT3 (SIN3)-LIKE1 (SNL1) and SNL2, results in accelerated radicle protrusion and growth during...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13412
更新日期:2016-11-11 00:00:00
abstract::High-index dielectric nanoparticles supporting a distinct series of Mie resonances have enabled a new class of optical antennas with unprecedented functionalities. The great wealth of multipolar responses has not only brought in new physical insight but also spurred practical applications. However, how to make such a ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08057-1
更新日期:2019-01-23 00:00:00
abstract::Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9986
更新日期:2015-11-23 00:00:00
abstract::Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2286
更新日期:2012-01-01 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms14778. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms15574
更新日期:2017-05-24 00:00:00
abstract::Fatigue is a difficult multi-scale modelling problem nucleating from localised plasticity at the scale of dislocations and microstructure with significant engineering safety implications. Cold dwell fatigue is a phenomenon in titanium where stress holds at moderate temperatures lead to substantial reductions in cyclic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19470-w
更新日期:2020-11-17 00:00:00
abstract::Efficient organic light-emitting diodes have been developed using emitters containing rare metals, such as platinum and iridium complexes. However, there is an urgent need to develop emitters composed of more abundant materials. Here we show a thermally activated delayed fluorescence material for organic light-emittin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9476
更新日期:2015-10-19 00:00:00
abstract::Seismic tomography provides unique constraints on the morphology, the deformation, and (indirectly) the rheology of subducting slabs. We use teleseismic double-difference P-wave tomography to image with unprecedented clarity the structural complexity of the Izu-Bonin slab. We resolve a tear in the slab in the mantle t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09279-7
更新日期:2019-03-21 00:00:00
abstract::A nest of begging chicks invites an intuitive explanation: needy chicks want to be fed and parents want to feed them. Surprisingly, however, in a quarter of species studied, parents ignore begging chicks. Furthermore, parents in some species even neglect smaller chicks that beg more, and preferentially feed the bigges...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10985
更新日期:2016-03-29 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14601-9
更新日期:2020-02-06 00:00:00
abstract::To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the carrier that catalyzes ATP uptake into the ER was unknown. Here, we report that our screen of gene expression datasets for member(s) of the fam...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06003-9
更新日期:2018-08-28 00:00:00
abstract::Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12842-x
更新日期:2019-10-25 00:00:00
abstract::During homologous recombination, eukaryotic RecA homologue Rad51 assembles into a nucleoprotein filament on single-stranded DNA to catalyse homologous pairing and DNA-strand exchange with a homologous template. Rad51 nucleoprotein filaments are highly dynamic and regulated via the coordinated actions of various access...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2678
更新日期:2013-01-01 00:00:00
abstract::In recent years, there has been marked increase in research aimed to introduce alkali vapours into guided-wave configurations. Owing to the significant reduction in device dimensions, the increase in density of states, the interaction with surfaces and primarily the high intensities carried along the structure, a plet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14461
更新日期:2017-02-09 00:00:00
abstract::CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17029-3
更新日期:2020-06-26 00:00:00
abstract::Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16942-x
更新日期:2020-06-24 00:00:00
abstract::Genomic and phenotypic analyses indicate extensive intra- as well as intertumoral heterogeneity in primary human malignant cell populations despite their clonal origin. Cellular DNA barcoding offers a powerful and unbiased alternative to track the number and size of multiple subclones within a single human tumour xeno...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6871
更新日期:2014-12-23 00:00:00
abstract::The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09043-x
更新日期:2019-03-05 00:00:00
abstract::Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15322-9
更新日期:2020-04-14 00:00:00
abstract::In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09346-z
更新日期:2019-04-05 00:00:00
abstract::Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10601-6
更新日期:2019-06-28 00:00:00
abstract::The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16732-5
更新日期:2020-06-09 00:00:00
abstract::Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01297-7
更新日期:2017-11-03 00:00:00
abstract::Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5162
更新日期:2014-06-17 00:00:00
abstract::Biological cellular structures have inspired many scientific disciplines to design synthetic structures that can mimic their functions. Here, we closely emulate biological cellular structures in a rationally designed synthetic multicellular hybrid ion pump, composed of hydrogen-bonded [EMIM+][TFSI-] ion pairs on the s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11973-5
更新日期:2019-09-05 00:00:00
abstract::Practice improves perception and enhances neural representations of trained visual stimuli, a phenomenon known as visual perceptual learning (VPL). While attention to task-relevant stimuli plays an important role in such learning, Pavlovian stimulus-reinforcer associations are sufficient to drive VPL, even subconsciou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11527-9
更新日期:2019-08-09 00:00:00
abstract::Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question as to the translatome remodelers that titrate protein output from mRNA populations. Here, we uncover a net...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16504-1
更新日期:2020-05-29 00:00:00