Abstract:
:Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain barrier (BBB) formation. BBB formation and modulation are not only important for development, but also relevant for vascular and neurodegenerative diseases. However, there is little understanding of how Wnt signaling contributes to brain angiogenesis and BBB formation. Here we show, using high resolution in vivo imaging and temporal and spatial manipulation of Wnt signaling, different requirements for Wnt signaling during brain angiogenesis and BBB formation. In the absence of Wnt signaling, premature Sphingosine-1-phosphate receptor (S1pr) signaling reduces VE-cadherin and Esama at cell-cell junctions. We suggest that Wnt signaling suppresses S1pr signaling during angiogenesis to enable the dynamic junction formation during anastomosis, whereas later S1pr signaling regulates BBB maturation and VE-cadherin stabilization. Our data provides a link between brain angiogenesis and BBB formation and identifies Wnt signaling as coordinator of the timing and as regulator of anastomosis.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hübner K,Cabochette P,Diéguez-Hurtado R,Wiesner C,Wakayama Y,Grassme KS,Hubert M,Guenther S,Belting HG,Affolter M,Adams RH,Vanhollebeke B,Herzog Wdoi
10.1038/s41467-018-07302-xsubject
Has Abstractpub_date
2018-11-19 00:00:00pages
4860issue
1issn
2041-1723pii
10.1038/s41467-018-07302-xjournal_volume
9pub_type
杂志文章abstract::Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15667-1
更新日期:2020-04-14 00:00:00
abstract::Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01220-0
更新日期:2017-10-20 00:00:00
abstract::Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7691
更新日期:2015-04-07 00:00:00
abstract::Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03937-y
更新日期:2018-04-17 00:00:00
abstract::Despite rapid advances in genome engineering technologies, inserting genes into precise locations in the human genome remains an outstanding problem. It has been suggested that site-specific recombinases can be adapted towards use as transgene delivery vectors. The specificity of recombinases can be altered either wit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3509
更新日期:2013-01-01 00:00:00
abstract::Myoblast fusion (MF) is required for muscle growth and repair, and its alteration contributes to muscle diseases. The mechanisms governing this process are incompletely understood, and no epigenetic regulator has been previously described. Ash1L is an epigenetic activator belonging to the Trithorax group of proteins a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07313-8
更新日期:2018-11-28 00:00:00
abstract::Manganese based layered oxides have received increasing attention as cathode materials for sodium ion batteries due to their high theoretical capacities and good sodium ion conductivities. However, the Jahn-Teller distortion arising from the manganese (III) centers destabilizes the host structure and deteriorates the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07646-4
更新日期:2019-01-07 00:00:00
abstract::Following the discovery of high-temperature superconductivity in the La-H system, we studied the formation of new chemical compounds in the barium-hydrogen system at pressures from 75 to 173 GPa. Using in situ generation of hydrogen from NH3BH3, we synthesized previously unknown superhydride BaH12 with a pseudocubic (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20103-5
更新日期:2021-01-11 00:00:00
abstract::The magnetostructural coupling between the structural and the magnetic transition has a crucial role in magnetoresponsive effects in a martensitic-transition system. A combination of various magnetoresponsive effects based on this coupling may facilitate the multifunctional applications of a host material. Here we dem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1868
更新日期:2012-05-29 00:00:00
abstract::Solar-driven photocatalysis has attracted significant attention in water splitting, CO2 reduction and organic synthesis. The syntheses of valuable azo- and azoxyaromatic dyes via selective photoreduction of nitroaromatic compounds have been realised using supported plasmonic metal nanoparticles at elevated temperature...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02527-8
更新日期:2018-01-04 00:00:00
abstract::Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal surfaces. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6822
更新日期:2014-12-19 00:00:00
abstract::Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15559
更新日期:2017-05-30 00:00:00
abstract::The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07960-x
更新日期:2019-01-03 00:00:00
abstract::Since the pioneering proposal of the replicon model of DNA replication 50 years ago, the predicted replicons have not been identified and quantified at the cellular level. Here, we combine conventional and super-resolution microscopy of replication sites in live and fixed cells with computational image analysis. We co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11231
更新日期:2016-04-07 00:00:00
abstract::Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14106-0
更新日期:2020-02-05 00:00:00
abstract::Many physical phenomena can be understood by single-particle physics; that is, treating particles as non-interacting entities. When this fails, many-body interactions lead to spontaneous symmetry breaking and phenomena such as fundamental particles' mass generation, superconductivity and magnetism. Competition between...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6656
更新日期:2014-12-12 00:00:00
abstract::Vibrio cholerae, responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host immune system, facilitating colonization of small intestine. Unlike other effector domains of the multifunctional toxin that target cytoskeleton, the function o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9745
更新日期:2015-10-26 00:00:00
abstract::HER2-targeted therapy has yielded a significant clinical benefit in patients with HER2+ breast cancer, yet disease relapse due to intrinsic or acquired resistance remains a significant challenge in the clinic. Here, we show that the protein phosphatase 2A (PP2A) regulatory subunit PPP2R2B is a crucial determinant of a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19704-x
更新日期:2020-11-18 00:00:00
abstract::Plasma dynamics critically depends on density and temperature, thus well-controlled experimental realizations are essential benchmarks for theoretical models. The formation of an ultracold plasma can be triggered by ionizing a tunable number of atoms in a micrometer-sized volume of a 87Rb Bose-Einstein condensate (BEC...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20815-8
更新日期:2021-01-26 00:00:00
abstract::A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-018-06695-z
更新日期:2018-11-16 00:00:00
abstract::Pulses of tree mortality caused by drought have been reported recently in forests around the globe, but large-scale quantitative evidence is lacking for Europe. Analyzing high-resolution annual satellite-based canopy mortality maps from 1987 to 2016 we here show that excess forest mortality (i.e., canopy mortality exc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19924-1
更新日期:2020-12-03 00:00:00
abstract::Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12667
更新日期:2016-10-11 00:00:00
abstract::The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report the existence of a hepatobiliary hybrid progenitor (HHyP) population i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11266-x
更新日期:2019-07-26 00:00:00
abstract::The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15691
更新日期:2017-06-13 00:00:00
abstract::COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18709-w
更新日期:2020-10-07 00:00:00
abstract::Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in vitro is an important step for the development of cell transplantat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10351
更新日期:2016-01-14 00:00:00
abstract::Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19106-z
更新日期:2020-10-20 00:00:00
abstract::Although hexagonal boron nitride (h-BN) is a good candidate for gate-insulating materials by minimizing interaction from substrate, further applications to electronic devices with available two-dimensional semiconductors continue to be limited by flake size. While monolayer h-BN has been synthesized on Pt and Cu foil ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9662
更新日期:2015-10-28 00:00:00
abstract::High harmonics generated by counter-rotating laser fields at the fundamental and second harmonic frequencies have raised important interest as a table-top source of circularly polarized ultrashort extreme-ultraviolet light. However, this emission has not yet been fully characterized: in particular it was assumed to be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07151-8
更新日期:2018-11-09 00:00:00
abstract::Although B cell response is frequently found in cancer, there is little evidence that it alters tumor development or progression. The process through which tumor-associated antigens trigger humoral response is not well delineated. We investigate the repertoire of antigens associated with humoral immune response in pan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08109-6
更新日期:2019-01-16 00:00:00